FI68323C - Glukosgivare - Google Patents
Glukosgivare Download PDFInfo
- Publication number
- FI68323C FI68323C FI820328A FI820328A FI68323C FI 68323 C FI68323 C FI 68323C FI 820328 A FI820328 A FI 820328A FI 820328 A FI820328 A FI 820328A FI 68323 C FI68323 C FI 68323C
- Authority
- FI
- Finland
- Prior art keywords
- voltage
- sweep
- glucose
- electrode
- charge
- Prior art date
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 67
- 239000008103 glucose Substances 0.000 claims description 67
- 239000007788 liquid Substances 0.000 claims description 10
- 230000010354 integration Effects 0.000 claims description 9
- 230000035945 sensitivity Effects 0.000 claims description 9
- 239000013060 biological fluid Substances 0.000 claims description 6
- 238000003487 electrochemical reaction Methods 0.000 claims description 6
- 230000002452 interceptive effect Effects 0.000 claims description 6
- 230000003647 oxidation Effects 0.000 claims description 5
- 238000007254 oxidation reaction Methods 0.000 claims description 5
- 230000003197 catalytic effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 claims 2
- 238000006056 electrooxidation reaction Methods 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 description 17
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 15
- 239000004202 carbamide Substances 0.000 description 15
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 15
- 150000001413 amino acids Chemical class 0.000 description 14
- 230000001419 dependent effect Effects 0.000 description 10
- 229910052697 platinum Inorganic materials 0.000 description 7
- 239000012528 membrane Substances 0.000 description 5
- 239000000872 buffer Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000007853 buffer solution Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 239000012891 Ringer solution Substances 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000002715 bioenergetic effect Effects 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000003014 ion exchange membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000002161 passivation Methods 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- -1 urine Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/155,198 US4340458A (en) | 1980-06-02 | 1980-06-02 | Glucose sensor |
| US15519880 | 1980-06-02 | ||
| PCT/US1981/000725 WO1981003546A1 (en) | 1980-06-02 | 1981-06-01 | Method and apparatus for determining glucose in biological fluids |
| US8100725 | 1981-06-01 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI820328L FI820328L (fi) | 1982-02-02 |
| FI68323B FI68323B (fi) | 1985-04-30 |
| FI68323C true FI68323C (fi) | 1985-08-12 |
Family
ID=22554460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI820328A FI68323C (fi) | 1980-06-02 | 1982-02-02 | Glukosgivare |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US4340458A (da) |
| EP (1) | EP0052148A4 (da) |
| JP (1) | JPS57500899A (da) |
| AU (1) | AU546417B2 (da) |
| BR (1) | BR8108636A (da) |
| CA (1) | CA1152155A (da) |
| CH (1) | CH660922A5 (da) |
| DE (1) | DE3152065A1 (da) |
| DK (1) | DK42982A (da) |
| FI (1) | FI68323C (da) |
| GB (2) | GB2089048B (da) |
| MX (1) | MX151191A (da) |
| NL (1) | NL8120252A (da) |
| NO (1) | NO159421C (da) |
| SE (2) | SE434887B (da) |
| WO (1) | WO1981003546A1 (da) |
Families Citing this family (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4407959A (en) * | 1980-10-29 | 1983-10-04 | Fuji Electric Co., Ltd. | Blood sugar analyzing apparatus |
| DE3129988A1 (de) * | 1981-07-29 | 1983-02-17 | Siemens AG, 1000 Berlin und 8000 München | "verfahren und vorrichtung zur bestimmung von harnstoff" |
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| US4729824A (en) * | 1982-05-11 | 1988-03-08 | Giner, Inc. | Gas sensor and method of using same |
| DE3228542A1 (de) * | 1982-07-30 | 1984-02-02 | Siemens AG, 1000 Berlin und 8000 München | Verfahren zur bestimmung der konzentration elektrochemisch umsetzbarer stoffe |
| DE3228551A1 (de) * | 1982-07-30 | 1984-02-02 | Siemens AG, 1000 Berlin und 8000 München | Verfahren zur bestimmung der zuckerkonzentration |
| US4826810A (en) * | 1983-12-16 | 1989-05-02 | Aoki Thomas T | System and method for treating animal body tissues to improve the dietary fuel processing capabilities thereof |
| US5030333A (en) * | 1984-09-13 | 1991-07-09 | Children's Hospital Medical Center | Polarographic method for measuring both analyte and oxygen with the same detecting electrode of an electroenzymatic sensor |
| GB2175399B (en) * | 1985-05-20 | 1989-10-11 | Us Energy | Selective chemical detection by energy modulation of sensors |
| US5047352A (en) * | 1985-05-20 | 1991-09-10 | Arch Development Corporation | Selective chemical detection by energy modulation of sensors |
| US4805624A (en) * | 1985-09-09 | 1989-02-21 | The Montefiore Hospital Association Of Western Pa | Low-potential electrochemical redox sensors |
| US4890620A (en) * | 1985-09-20 | 1990-01-02 | The Regents Of The University Of California | Two-dimensional diffusion glucose substrate sensing electrode |
| US4703756A (en) * | 1986-05-06 | 1987-11-03 | The Regents Of The University Of California | Complete glucose monitoring system with an implantable, telemetered sensor module |
| US5002572A (en) * | 1986-09-11 | 1991-03-26 | Picha George J | Biological implant with textured surface |
| US4897162A (en) * | 1986-11-14 | 1990-01-30 | The Cleveland Clinic Foundation | Pulse voltammetry |
| US4974929A (en) * | 1987-09-22 | 1990-12-04 | Baxter International, Inc. | Fiber optical probe connector for physiologic measurement devices |
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| TW279133B (da) * | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
| US5593852A (en) | 1993-12-02 | 1997-01-14 | Heller; Adam | Subcutaneous glucose electrode |
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| US5773270A (en) * | 1991-03-12 | 1998-06-30 | Chiron Diagnostics Corporation | Three-layered membrane for use in an electrochemical sensor system |
| US5271736A (en) * | 1991-05-13 | 1993-12-21 | Applied Medical Research | Collagen disruptive morphology for implants |
| US5387327A (en) * | 1992-10-19 | 1995-02-07 | Duquesne University Of The Holy Ghost | Implantable non-enzymatic electrochemical glucose sensor |
| GB9325189D0 (en) * | 1993-12-08 | 1994-02-09 | Unilever Plc | Methods and apparatus for electrochemical measurements |
| IE72524B1 (en) * | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
| US5743262A (en) * | 1995-06-07 | 1998-04-28 | Masimo Corporation | Blood glucose monitoring system |
| US5711861A (en) * | 1995-11-22 | 1998-01-27 | Ward; W. Kenneth | Device for monitoring changes in analyte concentration |
| US5776324A (en) * | 1996-05-17 | 1998-07-07 | Encelle, Inc. | Electrochemical biosensors |
| AU6157898A (en) | 1997-02-06 | 1998-08-26 | E. Heller & Company | Small volume (in vitro) analyte sensor |
| US8527026B2 (en) | 1997-03-04 | 2013-09-03 | Dexcom, Inc. | Device and method for determining analyte levels |
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US6862465B2 (en) * | 1997-03-04 | 2005-03-01 | Dexcom, Inc. | Device and method for determining analyte levels |
| CA2294610A1 (en) | 1997-06-16 | 1998-12-23 | George Moshe Katz | Methods of calibrating and testing a sensor for in vivo measurement of an analyte and devices for use in such methods |
| US5922339A (en) * | 1998-01-27 | 1999-07-13 | Usala; Anton-Lewis | Compositions and methods for biocompatible implants |
| US6103033A (en) | 1998-03-04 | 2000-08-15 | Therasense, Inc. | Process for producing an electrochemical biosensor |
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| US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
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| US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
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| US7381184B2 (en) | 2002-11-05 | 2008-06-03 | Abbott Diabetes Care Inc. | Sensor inserter assembly |
| DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
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| US8771183B2 (en) | 2004-02-17 | 2014-07-08 | Abbott Diabetes Care Inc. | Method and system for providing data communication in continuous glucose monitoring and management system |
| US8066639B2 (en) | 2003-06-10 | 2011-11-29 | Abbott Diabetes Care Inc. | Glucose measuring device for use in personal area network |
| CN1867826B (zh) | 2003-08-21 | 2010-12-08 | 埃葛梅崔克斯股份有限公司 | 化验电化学性质的方法和设备 |
| USD914881S1 (en) | 2003-11-05 | 2021-03-30 | Abbott Diabetes Care Inc. | Analyte sensor electronic mount |
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| US9788771B2 (en) | 2006-10-23 | 2017-10-17 | Abbott Diabetes Care Inc. | Variable speed sensor insertion devices and methods of use |
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| US10226207B2 (en) | 2004-12-29 | 2019-03-12 | Abbott Diabetes Care Inc. | Sensor inserter having introducer |
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| MX2008000836A (es) | 2005-07-20 | 2008-03-26 | Bayer Healthcare Llc | Amperimetria regulada. |
| US20070117171A1 (en) * | 2005-09-13 | 2007-05-24 | Greta Wegner | Method of manufacturing a diagnostic test strip |
| US9521968B2 (en) | 2005-09-30 | 2016-12-20 | Abbott Diabetes Care Inc. | Analyte sensor retention mechanism and methods of use |
| EP1934591B1 (en) * | 2005-09-30 | 2019-01-02 | Ascensia Diabetes Care Holdings AG | Gated voltammetry |
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| US11298058B2 (en) | 2005-12-28 | 2022-04-12 | Abbott Diabetes Care Inc. | Method and apparatus for providing analyte sensor insertion |
| EP1968432A4 (en) | 2005-12-28 | 2009-10-21 | Abbott Diabetes Care Inc | INTRODUCTION OF A MEDICAL DEVICE |
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| US7620438B2 (en) | 2006-03-31 | 2009-11-17 | Abbott Diabetes Care Inc. | Method and system for powering an electronic device |
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| DE102006043718B4 (de) * | 2006-09-18 | 2014-12-31 | Alexander Adlassnig | Bestimmung von Wasserstoffperoxidkonzentrationen |
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| DE1422172B1 (de) | 1961-12-07 | 1970-11-12 | Kopperschmidt & Co Carl W | Periskop |
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| CA977419A (en) * | 1971-10-06 | 1975-11-04 | Keith B. Oldham | Electroanalysis system employing semi-integration or semi-differentiation |
| US4140963A (en) * | 1972-01-03 | 1979-02-20 | Siemens Aktiengesellschaft | Device for measuring sugar concentration |
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-
1980
- 1980-06-02 US US06/155,198 patent/US4340458A/en not_active Expired - Lifetime
-
1981
- 1981-06-01 GB GB8202427A patent/GB2089048B/en not_active Expired
- 1981-06-01 WO PCT/US1981/000725 patent/WO1981003546A1/en not_active Application Discontinuation
- 1981-06-01 EP EP19810901848 patent/EP0052148A4/en not_active Withdrawn
- 1981-06-01 AU AU74126/81A patent/AU546417B2/en not_active Ceased
- 1981-06-01 CH CH726/82A patent/CH660922A5/de not_active IP Right Cessation
- 1981-06-01 DE DE813152065T patent/DE3152065A1/de not_active Withdrawn
- 1981-06-01 GB GB08404395A patent/GB2140567B/en not_active Expired
- 1981-06-01 JP JP56502289A patent/JPS57500899A/ja active Pending
- 1981-06-01 BR BR8108636A patent/BR8108636A/pt unknown
- 1981-06-01 CA CA000378793A patent/CA1152155A/en not_active Expired
- 1981-06-01 NL NL8120252A patent/NL8120252A/nl unknown
- 1981-06-02 MX MX187601A patent/MX151191A/es unknown
-
1982
- 1982-01-29 SE SE8200511A patent/SE434887B/sv not_active IP Right Cessation
- 1982-01-29 NO NO82820274A patent/NO159421C/no unknown
- 1982-02-01 DK DK42982A patent/DK42982A/da not_active Application Discontinuation
- 1982-02-02 FI FI820328A patent/FI68323C/fi not_active IP Right Cessation
- 1982-04-22 US US06/370,735 patent/US4396464A/en not_active Expired - Lifetime
-
1983
- 1983-07-25 SE SE8304129A patent/SE434888B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1981003546A1 (en) | 1981-12-10 |
| SE434888B (sv) | 1984-08-20 |
| NL8120252A (da) | 1982-05-03 |
| DE3152065A1 (de) | 1982-08-12 |
| US4396464A (en) | 1983-08-02 |
| AU546417B2 (en) | 1985-08-29 |
| NO820274L (no) | 1982-01-29 |
| SE434887B (sv) | 1984-08-20 |
| DK42982A (da) | 1982-02-01 |
| SE8200511L (sv) | 1982-01-29 |
| GB8404395D0 (en) | 1984-03-28 |
| GB2089048A (en) | 1982-06-16 |
| AU7412681A (en) | 1981-12-21 |
| CH660922A5 (de) | 1987-05-29 |
| GB2140567A (en) | 1984-11-28 |
| NO159421C (no) | 1988-12-21 |
| GB2140567B (en) | 1985-06-05 |
| FI68323B (fi) | 1985-04-30 |
| SE8304129L (sv) | 1983-07-25 |
| NO159421B (no) | 1988-09-12 |
| JPS57500899A (da) | 1982-05-20 |
| EP0052148A1 (en) | 1982-05-26 |
| SE8304129D0 (sv) | 1983-07-25 |
| MX151191A (es) | 1984-10-09 |
| GB2089048B (en) | 1985-01-30 |
| CA1152155A (en) | 1983-08-16 |
| FI820328L (fi) | 1982-02-02 |
| US4340458A (en) | 1982-07-20 |
| BR8108636A (pt) | 1982-04-13 |
| EP0052148A4 (en) | 1983-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: JOSLIN DIABETES CENTER, INC. |