FI68262C - Foerfarande foer konstatering av juverinflammation - Google Patents
Foerfarande foer konstatering av juverinflammation Download PDFInfo
- Publication number
- FI68262C FI68262C FI824348A FI824348A FI68262C FI 68262 C FI68262 C FI 68262C FI 824348 A FI824348 A FI 824348A FI 824348 A FI824348 A FI 824348A FI 68262 C FI68262 C FI 68262C
- Authority
- FI
- Finland
- Prior art keywords
- milk
- mastitis
- trypsin
- samples
- antitrypsin
- Prior art date
Links
- 235000013336 milk Nutrition 0.000 description 40
- 210000004080 milk Anatomy 0.000 description 40
- 239000008267 milk Substances 0.000 description 40
- 238000000034 method Methods 0.000 description 28
- 208000004396 mastitis Diseases 0.000 description 20
- 239000002753 trypsin inhibitor Substances 0.000 description 20
- 102000004142 Trypsin Human genes 0.000 description 16
- 108090000631 Trypsin Proteins 0.000 description 16
- 239000012588 trypsin Substances 0.000 description 16
- 238000005259 measurement Methods 0.000 description 10
- 101710081722 Antitrypsin Proteins 0.000 description 9
- 230000001475 anti-trypsic effect Effects 0.000 description 9
- 241000283690 Bos taurus Species 0.000 description 8
- 235000013365 dairy product Nutrition 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 229940122618 Trypsin inhibitor Drugs 0.000 description 6
- 101710162629 Trypsin inhibitor Proteins 0.000 description 6
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 108010088751 Albumins Proteins 0.000 description 4
- 102000009027 Albumins Human genes 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 3
- RKDYKIHMFYAPMZ-INIZCTEOSA-N ac1mbmqr Chemical compound N([C@@H](CCCN=C(N)N)C(=O)NC=1C=CC(=CC=1)[N+]([O-])=O)C(=O)C1=CC=CC=C1 RKDYKIHMFYAPMZ-INIZCTEOSA-N 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000000415 inactivating effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000002797 proteolythic effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 1
- TYMLOMAKGOJONV-UHFFFAOYSA-N 4-nitroaniline Chemical compound NC1=CC=C([N+]([O-])=O)C=C1 TYMLOMAKGOJONV-UHFFFAOYSA-N 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 208000031462 Bovine Mastitis Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- DEOKFPFLXFNAON-UHFFFAOYSA-N N-α-Benzoyl-DL-arginine 4-nitroanilide hydrochloride Chemical compound Cl.C=1C=C([N+]([O-])=O)C=CC=1NC(=O)C(CCCN=C(N)N)NC(=O)C1=CC=CC=C1 DEOKFPFLXFNAON-UHFFFAOYSA-N 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 235000021277 colostrum Nutrition 0.000 description 1
- 210000003022 colostrum Anatomy 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8121—Serpins
- G01N2333/8125—Alpha-1-antitrypsin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/976—Trypsin; Chymotrypsin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI824348A FI68262C (fi) | 1982-12-17 | 1982-12-17 | Foerfarande foer konstatering av juverinflammation |
| DE8484900057T DE3373677D1 (en) | 1982-12-17 | 1983-12-14 | Method for the detection of inflammation of the udder |
| AT84900057T ATE29737T1 (de) | 1982-12-17 | 1983-12-14 | Verfahren zum aufspueren der entzuendung des euters. |
| JP84500346A JPS60500144A (ja) | 1982-12-17 | 1983-12-14 | ウシなどの乳腺炎の測定方法 |
| PCT/FI1983/000079 WO1984002352A1 (en) | 1982-12-17 | 1983-12-14 | Method for the detection of inflammation of the udder |
| EP84900057A EP0128179B1 (de) | 1982-12-17 | 1983-12-14 | Verfahren zum aufspüren der entzündung des euters |
| DD83258080A DD215581A5 (de) | 1982-12-17 | 1983-12-16 | Verfahren fuer die ermittlung von euterentzuendungen |
| US06/620,157 US4659656A (en) | 1982-12-17 | 1984-06-13 | Method of detecting mastitis in cows |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI824348A FI68262C (fi) | 1982-12-17 | 1982-12-17 | Foerfarande foer konstatering av juverinflammation |
| FI824348 | 1982-12-17 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI824348A0 FI824348A0 (fi) | 1982-12-17 |
| FI824348L FI824348L (fi) | 1984-06-18 |
| FI68262B FI68262B (fi) | 1985-04-30 |
| FI68262C true FI68262C (fi) | 1985-08-12 |
Family
ID=8516471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI824348A FI68262C (fi) | 1982-12-17 | 1982-12-17 | Foerfarande foer konstatering av juverinflammation |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4659656A (de) |
| EP (1) | EP0128179B1 (de) |
| DD (1) | DD215581A5 (de) |
| DE (1) | DE3373677D1 (de) |
| FI (1) | FI68262C (de) |
| WO (1) | WO1984002352A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1254119A (en) * | 1984-07-20 | 1989-05-16 | Lloyd A. Schick | Single step protease inhibitor assay |
| DE3531778A1 (de) * | 1985-09-06 | 1987-03-12 | Behringwerke Ag | Verfahren zur bestimmung von proteaseinhibitoren |
| US5026638A (en) * | 1988-07-27 | 1991-06-25 | George Saperstein | Antibiotic sensitivity test for pathogenic organisms present in mastitic milk |
| NZ531794A (en) * | 2004-03-25 | 2006-02-24 | Sensortec Ltd | Sample mechanism with integrated liquid detection |
| CA3097360A1 (en) * | 2018-04-19 | 2019-10-24 | Ellie LLC | Sample clarification and reduction of background fluorescence for fluorescent detection of analytes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3926732A (en) * | 1973-02-16 | 1975-12-16 | Alfa Laval Ab | Method for assaying catalase in milk and other liquids |
| DE2936543A1 (de) * | 1979-09-10 | 1981-04-09 | Behringwerke Ag, 3550 Marburg | Chromogene verbindungen |
| US4425330A (en) * | 1981-05-20 | 1984-01-10 | Cornell Research Foundation, Inc. | Bovine mastitis vaccine and method for detecting efficacy thereof |
-
1982
- 1982-12-17 FI FI824348A patent/FI68262C/fi not_active IP Right Cessation
-
1983
- 1983-12-14 DE DE8484900057T patent/DE3373677D1/de not_active Expired
- 1983-12-14 WO PCT/FI1983/000079 patent/WO1984002352A1/en not_active Ceased
- 1983-12-14 EP EP84900057A patent/EP0128179B1/de not_active Expired
- 1983-12-16 DD DD83258080A patent/DD215581A5/de not_active IP Right Cessation
-
1984
- 1984-06-13 US US06/620,157 patent/US4659656A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI68262B (fi) | 1985-04-30 |
| DE3373677D1 (en) | 1987-10-22 |
| DD215581A5 (de) | 1984-11-14 |
| FI824348L (fi) | 1984-06-18 |
| WO1984002352A1 (en) | 1984-06-21 |
| FI824348A0 (fi) | 1982-12-17 |
| US4659656A (en) | 1987-04-21 |
| EP0128179B1 (de) | 1987-09-16 |
| EP0128179A1 (de) | 1984-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: LABSYSTEMS OY Owner name: EFLAB OY |