FI64575C - Foerfarande foer framstaellning av en terapeutiskt anvaendbar somatostatinanalog - Google Patents
Foerfarande foer framstaellning av en terapeutiskt anvaendbar somatostatinanalog Download PDFInfo
- Publication number
- FI64575C FI64575C FI781183A FI781183A FI64575C FI 64575 C FI64575 C FI 64575C FI 781183 A FI781183 A FI 781183A FI 781183 A FI781183 A FI 781183A FI 64575 C FI64575 C FI 64575C
- Authority
- FI
- Finland
- Prior art keywords
- resin
- acid
- somatostatin
- minutes
- compound
- Prior art date
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- UXZMLECYBHANRH-UHFFFAOYSA-K [B+3].[O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F Chemical compound [B+3].[O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F UXZMLECYBHANRH-UHFFFAOYSA-K 0.000 description 1
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- 235000019445 benzyl alcohol Nutrition 0.000 description 1
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- ZOAIGCHJWKDIPJ-UHFFFAOYSA-M caesium acetate Chemical compound [Cs+].CC([O-])=O ZOAIGCHJWKDIPJ-UHFFFAOYSA-M 0.000 description 1
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- 125000005170 cycloalkyloxycarbonyl group Chemical group 0.000 description 1
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- 239000003085 diluting agent Substances 0.000 description 1
- UXGNZZKBCMGWAZ-UHFFFAOYSA-N dimethylformamide dmf Chemical compound CN(C)C=O.CN(C)C=O UXGNZZKBCMGWAZ-UHFFFAOYSA-N 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
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- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 1
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- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
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- 230000009036 growth inhibition Effects 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
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- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002267 hypothalamic effect Effects 0.000 description 1
- 150000003949 imides Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 150000002500 ions Chemical group 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000017066 negative regulation of growth Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- AHWALFGBDFAJAI-UHFFFAOYSA-N phenyl carbonochloridate Chemical compound ClC(=O)OC1=CC=CC=C1 AHWALFGBDFAJAI-UHFFFAOYSA-N 0.000 description 1
- 229960005190 phenylalanine Drugs 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 230000001148 spastic effect Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78947377A | 1977-04-21 | 1977-04-21 | |
| US78947377 | 1977-04-21 | ||
| US04/874,173 US4151394A (en) | 1978-02-01 | 1978-02-01 | Guidance system for arc welder |
| US87417378 | 1978-02-01 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI781183A7 FI781183A7 (fi) | 1978-10-22 |
| FI64575B FI64575B (fi) | 1983-08-31 |
| FI64575C true FI64575C (fi) | 1983-12-12 |
Family
ID=27120917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI781183A FI64575C (fi) | 1977-04-21 | 1978-04-18 | Foerfarande foer framstaellning av en terapeutiskt anvaendbar somatostatinanalog |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS53132589A (de) |
| AR (1) | AR229798A1 (de) |
| AT (1) | AT360675B (de) |
| AU (1) | AU518731B2 (de) |
| BG (2) | BG28704A3 (de) |
| CA (1) | CA1120030A (de) |
| CH (1) | CH634040A5 (de) |
| DD (1) | DD136739A5 (de) |
| DE (1) | DE2816855A1 (de) |
| DK (1) | DK174178A (de) |
| EG (1) | EG14800A (de) |
| ES (2) | ES469004A1 (de) |
| FI (1) | FI64575C (de) |
| FR (1) | FR2387942A1 (de) |
| GB (1) | GB1596329A (de) |
| GR (1) | GR69789B (de) |
| IE (1) | IE46617B1 (de) |
| IL (1) | IL54532A (de) |
| IT (1) | IT1094471B (de) |
| NL (1) | NL7804219A (de) |
| NZ (1) | NZ187010A (de) |
| PT (1) | PT67912B (de) |
| SE (1) | SE7804398L (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8423431D0 (en) * | 1984-09-17 | 1984-10-24 | Sandoz Ltd | Organic compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2608336A1 (de) * | 1975-03-11 | 1976-09-30 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
| US4372884A (en) * | 1975-08-06 | 1983-02-08 | The Salk Institute For Biological Studies | Pharmaceutically active peptides |
-
1978
- 1978-04-17 GB GB14917/78A patent/GB1596329A/en not_active Expired
- 1978-04-18 FI FI781183A patent/FI64575C/fi not_active IP Right Cessation
- 1978-04-18 SE SE7804398A patent/SE7804398L/xx unknown
- 1978-04-18 AR AR271821A patent/AR229798A1/es active
- 1978-04-18 NZ NZ187010A patent/NZ187010A/xx unknown
- 1978-04-18 DE DE19782816855 patent/DE2816855A1/de not_active Withdrawn
- 1978-04-18 IL IL54532A patent/IL54532A/xx unknown
- 1978-04-18 PT PT67912A patent/PT67912B/pt unknown
- 1978-04-18 JP JP4621478A patent/JPS53132589A/ja active Pending
- 1978-04-19 EG EG265/78A patent/EG14800A/xx active
- 1978-04-19 IE IE766/78A patent/IE46617B1/en unknown
- 1978-04-19 FR FR7811581A patent/FR2387942A1/fr active Granted
- 1978-04-19 CA CA000301485A patent/CA1120030A/en not_active Expired
- 1978-04-19 GR GR56031A patent/GR69789B/el unknown
- 1978-04-20 ES ES469004A patent/ES469004A1/es not_active Expired
- 1978-04-20 NL NL7804219A patent/NL7804219A/xx not_active Application Discontinuation
- 1978-04-20 DK DK174178A patent/DK174178A/da active IP Right Grant
- 1978-04-20 IT IT22553/78A patent/IT1094471B/it active
- 1978-04-20 AT AT282978A patent/AT360675B/de not_active IP Right Cessation
- 1978-04-20 CH CH425878A patent/CH634040A5/de not_active IP Right Cessation
- 1978-04-21 AU AU35341/78A patent/AU518731B2/en not_active Expired
- 1978-04-21 BG BG039504A patent/BG28704A3/xx unknown
- 1978-04-21 BG BG040964A patent/BG28705A4/xx unknown
- 1978-04-21 DD DD78204949A patent/DD136739A5/de unknown
-
1979
- 1979-01-16 ES ES476913A patent/ES476913A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2387942B1 (de) | 1981-06-26 |
| NL7804219A (nl) | 1978-10-24 |
| FR2387942A1 (fr) | 1978-11-17 |
| AU518731B2 (en) | 1981-10-15 |
| IT7822553A0 (it) | 1978-04-20 |
| BG28705A4 (bg) | 1980-06-16 |
| IE46617B1 (en) | 1983-08-10 |
| ES476913A1 (es) | 1979-09-16 |
| AT360675B (de) | 1981-01-26 |
| EG14800A (en) | 1985-06-30 |
| JPS53132589A (en) | 1978-11-18 |
| IT1094471B (it) | 1985-08-02 |
| BG28704A3 (bg) | 1980-06-16 |
| ES469004A1 (es) | 1979-09-01 |
| DK174178A (da) | 1978-10-22 |
| DE2816855A1 (de) | 1978-11-02 |
| FI781183A7 (fi) | 1978-10-22 |
| AU3534178A (en) | 1979-10-25 |
| NZ187010A (en) | 1980-08-26 |
| SE7804398L (sv) | 1978-10-22 |
| ATA282978A (de) | 1980-06-15 |
| DD136739A5 (de) | 1979-07-25 |
| CA1120030A (en) | 1982-03-16 |
| AR229798A1 (es) | 1983-11-30 |
| GB1596329A (en) | 1981-08-26 |
| FI64575B (fi) | 1983-08-31 |
| IL54532A0 (en) | 1978-07-31 |
| CH634040A5 (en) | 1983-01-14 |
| IE780766L (en) | 1978-10-21 |
| PT67912A (en) | 1978-05-01 |
| PT67912B (en) | 1979-11-14 |
| IL54532A (en) | 1983-03-31 |
| GR69789B (de) | 1982-07-07 |
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Owner name: ELI LILLY AND COMPANY |