FI20011189A - A process for purifying polyactides and a process for purifying polyactides - Google Patents

A process for purifying polyactides and a process for purifying polyactides Download PDF

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Publication number
FI20011189A
FI20011189A FI20011189A FI20011189A FI20011189A FI 20011189 A FI20011189 A FI 20011189A FI 20011189 A FI20011189 A FI 20011189A FI 20011189 A FI20011189 A FI 20011189A FI 20011189 A FI20011189 A FI 20011189A
Authority
FI
Finland
Prior art keywords
polyactides
purifying
purifying polyactides
Prior art date
Application number
FI20011189A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI111268B (en
Inventor
Walter Prikoszovich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016840A external-priority patent/GB9016840D0/en
Priority claimed from GB909016882A external-priority patent/GB9016882D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of FI20011189A publication Critical patent/FI20011189A/en
Application granted granted Critical
Publication of FI111268B publication Critical patent/FI111268B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI20011189A 1990-08-01 2001-06-05 A method for purifying polylactides FI111268B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9016840 1990-08-01
GB909016840A GB9016840D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds
GB909016882A GB9016882D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds
GB9016882 1990-08-01

Publications (2)

Publication Number Publication Date
FI20011189A true FI20011189A (en) 2001-06-05
FI111268B FI111268B (en) 2003-06-30

Family

ID=26297417

Family Applications (2)

Application Number Title Priority Date Filing Date
FI913641A FI108040B (en) 1990-08-01 1991-07-30 Purified polylactides
FI20011189A FI111268B (en) 1990-08-01 2001-06-05 A method for purifying polylactides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI913641A FI108040B (en) 1990-08-01 1991-07-30 Purified polylactides

Country Status (27)

Country Link
EP (2) EP0816413B1 (en)
JP (1) JP3137368B2 (en)
KR (1) KR100255904B1 (en)
AT (1) AT402503B (en)
AU (1) AU650277B2 (en)
CA (1) CA2048200C (en)
CH (1) CH683772A5 (en)
CY (1) CY1986A (en)
DE (1) DE4124468B4 (en)
DK (2) DK0816413T3 (en)
ES (2) ES2243966T3 (en)
FI (2) FI108040B (en)
FR (1) FR2665453B1 (en)
GB (1) GB2246573B (en)
GR (1) GR3026322T3 (en)
HK (1) HK11797A (en)
HU (1) HUT59837A (en)
IE (1) IE66185B1 (en)
IL (1) IL99007A (en)
IT (1) IT1252944B (en)
LU (1) LU87985A1 (en)
MY (1) MY108621A (en)
NO (1) NO912960D0 (en)
NZ (1) NZ239184A (en)
PH (1) PH31047A (en)
PT (1) PT98491B (en)
TW (2) TW282477B (en)

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US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
JPH06116381A (en) * 1992-10-09 1994-04-26 Mitsui Toatsu Chem Inc Method for purifying polyhydroxycarboxylic acid
DE4412317A1 (en) * 1993-04-21 1994-10-27 Basf Ag Polylactide having a broadened molecular weight distribution
US5359026A (en) * 1993-07-30 1994-10-25 Cargill, Incorporated Poly(lactide) copolymer and process for manufacture thereof
US5496923A (en) * 1993-09-20 1996-03-05 Mitsui Toatsu Chemicals, Inc. Purification process of aliphatic polyester
ES2236700T3 (en) * 1993-11-19 2005-07-16 Janssen Pharmaceutica N.V. 1,2-MICROENCAPSULATED BENZAZOLS.
ZA951877B (en) * 1994-03-07 1996-09-09 Dow Chemical Co Bioactive and/or targeted dendrimer conjugates
CA2350638C (en) 1998-09-11 2009-11-24 Gerhard Schmidmaier Biologically active implants coated with a biodegradable polymer
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
US7067611B2 (en) 2001-07-10 2006-06-27 Kureha Corporation Polyhydroxycarboxylic acid and its production process
MXPA04003433A (en) * 2001-10-10 2004-08-11 Pf Medicament Prolonged release biodegradable microspheres and method for preparing same.
FR2830448B1 (en) * 2001-10-10 2004-03-19 Pf Medicament SUSTAINED RELEASE BIODEGRADABLE MICROSPHERES AND THEIR PREPARATION METHOD
GB0226993D0 (en) * 2002-11-19 2002-12-24 Novartis Ag Organic compounds
AU2013204972B2 (en) * 2002-11-19 2016-04-21 Novartis Ag Pharmaceutical composition comprising octreotide microparticles
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
EP1787658B1 (en) 2005-11-10 2012-03-14 CHEMI S.p.A. Sustained release formulations of somatostatin analogue inhibitors of growth hormone
CN101193531B (en) 2006-11-29 2010-12-01 富准精密工业(深圳)有限公司 Heat radiator
US8853351B2 (en) * 2007-12-31 2014-10-07 Samyang Biopharmaceuticals Corporation Highly pure amphiphilic copolymer comprising hydrophobic block from alpha-hydroxy acid and process for the preparation thereof
WO2010111238A2 (en) * 2009-03-23 2010-09-30 Micell Technologies, Inc. Improved biodegradable polymers
JP5594996B2 (en) 2009-09-14 2014-09-24 三菱重工業株式会社 Aircraft control system
US8722845B2 (en) 2010-06-21 2014-05-13 Lg Chem, Ltd. Polylactide resin having excellent heat resistance and preparation method thereof
EP2455414A1 (en) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Process for the production of resorbable polyesters
EP2455415A1 (en) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Method for manufacturing low-molecular resorbable polyesters, low-molecular resorbable polyester manufactured according to the method and application of same
CN105820332B (en) * 2015-01-09 2018-06-29 北京化工大学 A kind of star polyaminoacid and star polyaminoacid medicament-carried nano micelle and preparation method
EP3408305B1 (en) 2016-01-29 2024-03-06 Tolmar Inc. Purification and decolorization of polymers
SG11202001688WA (en) 2017-08-31 2020-03-30 Evonik Corp Improved resorbable polymer purification process
GR1009392B (en) * 2017-09-19 2018-10-25 Φαρματεν Αβεε Pharmaceutical composition comprising a peptide drug and method for the preparation thereof
GB2568526A (en) * 2017-11-20 2019-05-22 Rebio Tech Oy Composition
CN112940234B (en) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 Preparation method of high-purity poly (glycolide-lactide)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467970A (en) * 1975-05-02 1977-03-23 Ici Ltd Purification of polyethers
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
CH656884A5 (en) * 1983-08-26 1986-07-31 Sandoz Ag POLYOLESTERS, THEIR PRODUCTION AND USE.
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production
DE3583988D1 (en) * 1984-11-13 1991-10-10 Asahi Chemical Ind METHOD FOR CLEANING POLYALKYLENE ETHERS.
JP2551756B2 (en) * 1985-05-07 1996-11-06 武田薬品工業株式会社 Polyoxycarboxylic acid ester and method for producing the same
JPH0610252B2 (en) * 1985-08-21 1994-02-09 和光純薬工業株式会社 Polymer manufacturing method
DE3641692A1 (en) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg CATALYST-FREE RESORBABLE HOMOPOLYMERS AND COPOLYMERS
DE3708916A1 (en) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg METHOD FOR CLEANING RESORBABLE POLYESTERS
JP2714454B2 (en) * 1988-11-07 1998-02-16 三井東圧化学株式会社 Method for producing bioabsorbable polyester
EP0452111B1 (en) * 1990-04-13 1998-07-15 Takeda Chemical Industries, Ltd. Biodegradable high-molecular polymers, production and use thereof

Also Published As

Publication number Publication date
DK0816413T3 (en) 2005-08-29
PT98491B (en) 1997-12-31
ITRM910553A1 (en) 1993-01-23
FI108040B (en) 2001-11-15
PT98491A (en) 1992-06-30
EP0469520A3 (en) 1992-10-07
GR3026322T3 (en) 1998-06-30
GB9116396D0 (en) 1991-09-11
ITRM910553A0 (en) 1991-07-23
IE66185B1 (en) 1995-12-13
KR920003990A (en) 1992-03-27
HUT59837A (en) 1992-07-28
EP0469520B1 (en) 1998-02-25
DK0469520T3 (en) 1998-09-23
JP3137368B2 (en) 2001-02-19
DE4124468A1 (en) 1992-02-06
TW282477B (en) 1996-08-01
ATA151591A (en) 1996-10-15
AU8143091A (en) 1992-02-27
DE4124468B4 (en) 2010-10-28
EP0816413A2 (en) 1998-01-07
EP0816413A3 (en) 1998-11-11
ES2243966T3 (en) 2005-12-01
CA2048200C (en) 1999-06-29
JPH0641279A (en) 1994-02-15
FI111268B (en) 2003-06-30
GB2246573B (en) 1994-05-11
GB2246573A (en) 1992-02-05
NZ239184A (en) 1994-09-27
FI913641A (en) 1992-02-02
MY108621A (en) 1996-10-31
IL99007A0 (en) 1992-07-15
HK11797A (en) 1997-02-14
FR2665453A1 (en) 1992-02-07
AU650277B2 (en) 1994-06-16
KR100255904B1 (en) 2000-05-01
TW218025B (en) 1993-12-21
CA2048200A1 (en) 1992-02-02
IE912697A1 (en) 1992-02-12
ES2112259T3 (en) 1998-04-01
IL99007A (en) 1994-12-29
IT1252944B (en) 1995-07-05
EP0816413B1 (en) 2005-06-08
NO912960D0 (en) 1991-07-30
CH683772A5 (en) 1994-05-13
EP0469520A2 (en) 1992-02-05
AT402503B (en) 1997-06-25
FR2665453B1 (en) 1995-01-27
CY1986A (en) 1997-09-05
LU87985A1 (en) 1993-02-15
FI913641A0 (en) 1991-07-30
HU912452D0 (en) 1991-12-30
PH31047A (en) 1998-02-03

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