FI20002693A - Process for the preparation of carboxylic acids - Google Patents

Process for the preparation of carboxylic acids Download PDF

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Publication number
FI20002693A
FI20002693A FI20002693A FI20002693A FI20002693A FI 20002693 A FI20002693 A FI 20002693A FI 20002693 A FI20002693 A FI 20002693A FI 20002693 A FI20002693 A FI 20002693A FI 20002693 A FI20002693 A FI 20002693A
Authority
FI
Finland
Prior art keywords
opt
substd
alkyl
phenyl
alkoxy
Prior art date
Application number
FI20002693A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI108791B (en
Inventor
Ulrich Mueller
Richard Connell
Siegfried Goldmann
Rudi Gruetzmann
Martin Beuck
Hilmar Bischoff
Dirk Denzer
Anke Domdey-Bette
Stefan Wohlfeil
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI20002693A publication Critical patent/FI20002693A/en
Application granted granted Critical
Publication of FI108791B publication Critical patent/FI108791B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system

Abstract

Cycloalkano-indole derivs. and aza analogues of formula (I) and isomers and salts are new. R1-C=C-R2 = phenyl, pyridyl or a gp. of formula (a), all opt. substd. by 1-3 gps. R'; R8 = H or 1-4C alkyl; R3-C=C-R4 = phenyl, 4-8C cycloalkene or 4-8 membered oxocycloalkane (all opt. substd. by 1-3 gps. R'); R' = independently halo, CF3, COOH, OH, up to 6C alkoxy carbonyl, 1-6C alkoxy, or 1-6C alkyl (opt. substd. by OH or 1-4C alkoxy); R = H, 4-12C cycloalkyl or 1-12C alkyl; A = CO or CS; X = O, S or NR9; R9 = H or 1-6C alkyl (opt. substd. by OH or phenyl); R5 = phenyl or 5-8 membered, opt. unsatd. heterocyclic with 1-3 heteroatoms (S, N and/or O), (both opt. mono- to tri-substd. by NO2, COOH, halo, CN, 2-6C alkenyl, 1-6C alkoxy or alkyl (opt. substd. by OH, COOH, 1-6C alkoxy or up to 6C alkoxycarbonyl; and/or opt. mono- substd. by OR10 or NR11R12); R10 = H, 1-6C alkyl or 2-6C alkenyl; R11, R12 = H, phenyl, 1-6C alkyl, or up to 8C acyl (opt. subst. by NR13R14); R13, R14 = H or up to 8C acyl; R7 = H; R6 = H, COOH, 1-5 alkoxy, or 1-6C alkyl (opt. substd. by OH or OCOR15); or R6+R7 = O; R<15> = phenyl (opt. mono- to tri-substd., by halo, OH or 1-5C alkyl), or 1-22C alkyl or 2-22C alkenyl (both opt. substd. by OR16); R16 = H, benzyl, triphenylmethyl or up to 6C acyl. Also claimed are intermediates of formula (II).
FI20002693A 1994-10-04 2000-12-08 Process for the preparation of carboxylic acids FI108791B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4435477A DE4435477A1 (en) 1994-10-04 1994-10-04 Cycloalkano-indole and -azaindole derivatives
DE4435477 1994-10-04

Publications (2)

Publication Number Publication Date
FI20002693A true FI20002693A (en) 2000-12-08
FI108791B FI108791B (en) 2002-03-28

Family

ID=6529939

Family Applications (2)

Application Number Title Priority Date Filing Date
FI954681A FI113048B (en) 1994-10-04 1995-10-02 Carboline and carbazole derivatives, process for their preparation and intermediates are used in the process
FI20002693A FI108791B (en) 1994-10-04 2000-12-08 Process for the preparation of carboxylic acids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI954681A FI113048B (en) 1994-10-04 1995-10-02 Carboline and carbazole derivatives, process for their preparation and intermediates are used in the process

Country Status (36)

Country Link
US (6) US5684014A (en)
EP (1) EP0705831B1 (en)
JP (1) JP3901234B2 (en)
KR (1) KR100355986B1 (en)
CN (2) CN1183111C (en)
AT (1) ATE255580T1 (en)
AU (1) AU700609B2 (en)
CA (1) CA2159546C (en)
CZ (1) CZ291348B6 (en)
DE (2) DE4435477A1 (en)
DK (1) DK0705831T3 (en)
DZ (1) DZ1934A1 (en)
EE (1) EE03527B1 (en)
ES (1) ES2211890T3 (en)
FI (2) FI113048B (en)
HK (1) HK1005139A1 (en)
HN (1) HN1995009160A (en)
HR (1) HRP950505B1 (en)
HU (1) HU225052B1 (en)
IL (3) IL129641A0 (en)
MA (1) MA23683A1 (en)
MY (1) MY117282A (en)
NO (1) NO305365B1 (en)
NZ (1) NZ280130A (en)
PH (1) PH31400A (en)
PL (1) PL183154B1 (en)
PT (1) PT705831E (en)
RU (1) RU2157803C2 (en)
SG (1) SG63528A1 (en)
SI (1) SI0705831T1 (en)
SK (1) SK284260B6 (en)
SV (1) SV1995000062A (en)
TN (1) TNSN95098A1 (en)
TW (1) TW448175B (en)
UA (1) UA44700C2 (en)
ZA (1) ZA958297B (en)

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Also Published As

Publication number Publication date
FI954681A (en) 1996-04-05
SV1995000062A (en) 1996-07-10
AU3292095A (en) 1996-04-18
FI113048B (en) 2004-02-27
CN1183111C (en) 2005-01-05
DZ1934A1 (en) 2002-02-17
HRP950505A2 (en) 1997-08-31
US20030149073A1 (en) 2003-08-07
PT705831E (en) 2004-04-30
DE4435477A1 (en) 1996-04-11
ATE255580T1 (en) 2003-12-15
TNSN95098A1 (en) 1996-02-06
FI954681A0 (en) 1995-10-02
US6858622B2 (en) 2005-02-22
US5684014A (en) 1997-11-04
SI0705831T1 (en) 2004-02-29
US6479503B2 (en) 2002-11-12
KR960014126A (en) 1996-05-22
KR100355986B1 (en) 2003-01-06
EE03527B1 (en) 2001-10-15
EE9500071A (en) 1996-04-15
CZ291348B6 (en) 2003-02-12
CN1224715A (en) 1999-08-04
RU2157803C2 (en) 2000-10-20
EP0705831B1 (en) 2003-12-03
CN1050605C (en) 2000-03-22
MY117282A (en) 2004-06-30
HRP950505B1 (en) 2002-04-30
US20020147209A1 (en) 2002-10-10
UA44700C2 (en) 2002-03-15
CN1130631A (en) 1996-09-11
US20020055635A1 (en) 2002-05-09
DK0705831T3 (en) 2004-04-05
TW448175B (en) 2001-08-01
NO953930D0 (en) 1995-10-03
EP0705831A2 (en) 1996-04-10
SK123995A3 (en) 1996-06-05
AU700609B2 (en) 1999-01-07
HU225052B1 (en) 2006-05-29
EP0705831A3 (en) 1997-01-22
ES2211890T3 (en) 2004-07-16
NO953930L (en) 1996-04-09
PL183154B1 (en) 2002-05-31
IL115493A (en) 1999-10-28
DE59510839D1 (en) 2004-01-15
JPH08225526A (en) 1996-09-03
NZ280130A (en) 1996-05-28
IL129641A (en) 2000-08-31
HN1995009160A (en) 2000-04-24
SG63528A1 (en) 1999-03-30
MA23683A1 (en) 1996-07-01
NO305365B1 (en) 1999-05-18
SK284260B6 (en) 2004-12-01
JP3901234B2 (en) 2007-04-04
US6245775B1 (en) 2001-06-12
US6265431B1 (en) 2001-07-24
CZ256795A3 (en) 1996-04-17
PH31400A (en) 1998-10-29
IL129641A0 (en) 2000-02-29
ZA958297B (en) 1996-05-06
CA2159546C (en) 2010-12-14
HU9502891D0 (en) 1995-11-28
PL310756A1 (en) 1996-04-15
FI108791B (en) 2002-03-28
IL115493A0 (en) 1996-01-19
HK1005139A1 (en) 1998-12-24
CA2159546A1 (en) 1996-04-05
HUT73240A (en) 1996-07-29

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