HUP9903247A2 - Processes for preparing substituted chromanol derivatives and their intermediates - Google Patents
Processes for preparing substituted chromanol derivatives and their intermediatesInfo
- Publication number
- HUP9903247A2 HUP9903247A2 HU9903247A HUP9903247A HUP9903247A2 HU P9903247 A2 HUP9903247 A2 HU P9903247A2 HU 9903247 A HU9903247 A HU 9903247A HU P9903247 A HUP9903247 A HU P9903247A HU P9903247 A2 HUP9903247 A2 HU P9903247A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- intermediates
- processes
- chromanol derivatives
- preparing substituted
- Prior art date
Links
- SEBPXHSZHLFWRL-UHFFFAOYSA-N 3,4-dihydro-2,2,5,7,8-pentamethyl-2h-1-benzopyran-6-ol Chemical class O1C(C)(C)CCC2=C1C(C)=C(C)C(O)=C2C SEBPXHSZHLFWRL-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- -1 phenylsulphinyl Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical class C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical group C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Preparation of chromanol derivatives of formula (X) and their enantiomers comprises treating a compound of formula (IX) with a base. the R3-substituted benzoic acid moiety is attached to C6 or C7 of the chroman ring; R1 = (CH2)qCHR5R6; q = 0-4; R2,R3 = H, F, Cl or 1-6C alkyl, 1-6C alkoxy, phenylsulphinyl, phenylsulphonyl or S(O)n(1-6C alkyl) (all optionally substituted by 1-3 F); n = 0-2; R5 = H, 1-6C alkyl or Ph (substituted by R2); R6 = H, 1-6C alkyl, 3-8C cycloalkyl or 6-10C aryl or 5-10 membered heteroaryl (both optionally substituted by one or two R2 or Ph (optionally substituted by one or two R2)); R4 = 1-6C alkyl.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9903247A HUP9903247A3 (en) | 1997-08-25 | 1997-08-25 | Processes for preparing substituted chromanol derivatives and their intermediates |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9903247A HUP9903247A3 (en) | 1997-08-25 | 1997-08-25 | Processes for preparing substituted chromanol derivatives and their intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9903247A2 true HUP9903247A2 (en) | 2000-02-28 |
| HUP9903247A3 HUP9903247A3 (en) | 2002-01-28 |
Family
ID=89999444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9903247A HUP9903247A3 (en) | 1997-08-25 | 1997-08-25 | Processes for preparing substituted chromanol derivatives and their intermediates |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUP9903247A3 (en) |
-
1997
- 1997-08-25 HU HU9903247A patent/HUP9903247A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9903247A3 (en) | 2002-01-28 |
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