FI121236B - Menetelmä asbestialtistukseen liittyvien keuhkosyöpien tunnistamiseksi - Google Patents
Menetelmä asbestialtistukseen liittyvien keuhkosyöpien tunnistamiseksi Download PDFInfo
- Publication number
- FI121236B FI121236B FI20065032A FI20065032A FI121236B FI 121236 B FI121236 B FI 121236B FI 20065032 A FI20065032 A FI 20065032A FI 20065032 A FI20065032 A FI 20065032A FI 121236 B FI121236 B FI 121236B
- Authority
- FI
- Finland
- Prior art keywords
- asbestos
- lung cancer
- genes
- expression
- exposure
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 84
- 201000004656 asbestos-related lung carcinoma Diseases 0.000 title description 15
- 108090000623 proteins and genes Proteins 0.000 claims description 160
- 230000014509 gene expression Effects 0.000 claims description 139
- 239000010425 asbestos Substances 0.000 claims description 91
- 229910052895 riebeckite Inorganic materials 0.000 claims description 91
- 208000020816 lung neoplasm Diseases 0.000 claims description 71
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 66
- 201000005202 lung cancer Diseases 0.000 claims description 64
- 206010028980 Neoplasm Diseases 0.000 claims description 62
- 230000002759 chromosomal effect Effects 0.000 claims description 32
- 238000004458 analytical method Methods 0.000 claims description 27
- 201000011510 cancer Diseases 0.000 claims description 15
- 108700028369 Alleles Proteins 0.000 claims description 10
- 238000001514 detection method Methods 0.000 claims description 9
- 238000005516 engineering process Methods 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 108091092878 Microsatellite Proteins 0.000 claims description 4
- 230000036210 malignancy Effects 0.000 claims description 4
- 238000001001 laser micro-dissection Methods 0.000 claims description 3
- 101000616738 Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Proteins 0.000 claims description 2
- 101000994496 Homo sapiens cAMP-dependent protein kinase catalytic subunit alpha Proteins 0.000 claims description 2
- 102100021840 NAD-dependent protein deacetylase sirtuin-6 Human genes 0.000 claims description 2
- 102100024924 Protein kinase C alpha type Human genes 0.000 claims description 2
- 238000002509 fluorescent in situ hybridization Methods 0.000 claims 2
- 102100039836 F-box/LRR-repeat protein 12 Human genes 0.000 claims 1
- 101000885591 Homo sapiens F-box/LRR-repeat protein 12 Proteins 0.000 claims 1
- 239000000523 sample Substances 0.000 description 110
- 150000007523 nucleic acids Chemical class 0.000 description 104
- 102000039446 nucleic acids Human genes 0.000 description 99
- 108020004707 nucleic acids Proteins 0.000 description 99
- 210000004027 cell Anatomy 0.000 description 86
- 238000012360 testing method Methods 0.000 description 34
- 238000009396 hybridization Methods 0.000 description 31
- 102000004169 proteins and genes Human genes 0.000 description 31
- 108020004414 DNA Proteins 0.000 description 27
- 230000000295 complement effect Effects 0.000 description 27
- 230000003321 amplification Effects 0.000 description 26
- 238000003199 nucleic acid amplification method Methods 0.000 description 26
- 206010063599 Exposure to chemical pollution Diseases 0.000 description 21
- 208000009956 adenocarcinoma Diseases 0.000 description 21
- 210000004072 lung Anatomy 0.000 description 21
- 239000003550 marker Substances 0.000 description 21
- 206010041823 squamous cell carcinoma Diseases 0.000 description 21
- 238000003556 assay Methods 0.000 description 19
- 150000001413 amino acids Chemical class 0.000 description 18
- 102000040430 polynucleotide Human genes 0.000 description 18
- 108091033319 polynucleotide Proteins 0.000 description 18
- 239000002157 polynucleotide Substances 0.000 description 18
- 239000012634 fragment Substances 0.000 description 17
- 108090000765 processed proteins & peptides Proteins 0.000 description 17
- 238000004422 calculation algorithm Methods 0.000 description 16
- 239000002773 nucleotide Substances 0.000 description 16
- 125000003729 nucleotide group Chemical group 0.000 description 16
- 102000004196 processed proteins & peptides Human genes 0.000 description 16
- 230000000694 effects Effects 0.000 description 15
- 229920001184 polypeptide Polymers 0.000 description 15
- 210000001519 tissue Anatomy 0.000 description 15
- 229940079593 drug Drugs 0.000 description 14
- 239000003814 drug Substances 0.000 description 14
- 239000000835 fiber Substances 0.000 description 14
- 230000001105 regulatory effect Effects 0.000 description 14
- 201000010099 disease Diseases 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 12
- 239000000463 material Substances 0.000 description 11
- 239000000047 product Substances 0.000 description 11
- 238000012216 screening Methods 0.000 description 11
- 238000003786 synthesis reaction Methods 0.000 description 11
- 230000005856 abnormality Effects 0.000 description 10
- 238000012217 deletion Methods 0.000 description 10
- 230000037430 deletion Effects 0.000 description 10
- 208000037841 lung tumor Diseases 0.000 description 10
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 9
- 108091028043 Nucleic acid sequence Proteins 0.000 description 9
- 201000009546 lung large cell carcinoma Diseases 0.000 description 9
- 238000003752 polymerase chain reaction Methods 0.000 description 9
- 208000032818 Microsatellite Instability Diseases 0.000 description 8
- 206010041067 Small cell lung cancer Diseases 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 8
- 210000000349 chromosome Anatomy 0.000 description 8
- 238000010606 normalization Methods 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 208000000587 small cell lung carcinoma Diseases 0.000 description 8
- 238000006467 substitution reaction Methods 0.000 description 8
- 238000009739 binding Methods 0.000 description 7
- 239000002299 complementary DNA Substances 0.000 description 7
- 230000000391 smoking effect Effects 0.000 description 7
- 108020004705 Codon Proteins 0.000 description 6
- 238000007792 addition Methods 0.000 description 6
- 230000027455 binding Effects 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 108020004999 messenger RNA Proteins 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 206010073310 Occupational exposures Diseases 0.000 description 5
- 238000013459 approach Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000001186 cumulative effect Effects 0.000 description 5
- 230000002068 genetic effect Effects 0.000 description 5
- 238000003018 immunoassay Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 230000001404 mediated effect Effects 0.000 description 5
- 230000002685 pulmonary effect Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 4
- 238000010367 cloning Methods 0.000 description 4
- 239000013068 control sample Substances 0.000 description 4
- 238000002405 diagnostic procedure Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 231100000675 occupational exposure Toxicity 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 238000003757 reverse transcription PCR Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000013589 supplement Substances 0.000 description 4
- 208000033116 Asbestos intoxication Diseases 0.000 description 3
- 206010009944 Colon cancer Diseases 0.000 description 3
- 108010043471 Core Binding Factor Alpha 2 Subunit Proteins 0.000 description 3
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 3
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 3
- 101000702545 Homo sapiens Transcription activator BRG1 Proteins 0.000 description 3
- 108700005091 Immunoglobulin Genes Proteins 0.000 description 3
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 3
- 108090000315 Protein Kinase C Proteins 0.000 description 3
- 102000003923 Protein Kinase C Human genes 0.000 description 3
- 102100025373 Runt-related transcription factor 1 Human genes 0.000 description 3
- 102100031027 Transcription activator BRG1 Human genes 0.000 description 3
- 102100038965 WAP four-disulfide core domain protein 2 Human genes 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 3
- 206010003441 asbestosis Diseases 0.000 description 3
- 230000001174 ascending effect Effects 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 201000005296 lung carcinoma Diseases 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 239000002853 nucleic acid probe Substances 0.000 description 3
- -1 nucleoside triphosphates Chemical class 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 239000013610 patient sample Substances 0.000 description 3
- 150000004713 phosphodiesters Chemical class 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 238000002741 site-directed mutagenesis Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- HCAJQHYUCKICQH-VPENINKCSA-N 8-Oxo-7,8-dihydro-2'-deoxyguanosine Chemical compound C1=2NC(N)=NC(=O)C=2NC(=O)N1[C@H]1C[C@H](O)[C@@H](CO)O1 HCAJQHYUCKICQH-VPENINKCSA-N 0.000 description 2
- 241000945470 Arcturus Species 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 2
- AHCYMLUZIRLXAA-SHYZEUOFSA-N Deoxyuridine 5'-triphosphate Chemical compound O1[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(=O)NC(=O)C=C1 AHCYMLUZIRLXAA-SHYZEUOFSA-N 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 102000003817 Fos-related antigen 1 Human genes 0.000 description 2
- 108090000123 Fos-related antigen 1 Proteins 0.000 description 2
- 101000707471 Homo sapiens Serine incorporator 3 Proteins 0.000 description 2
- 101000777263 Homo sapiens UV radiation resistance-associated gene protein Proteins 0.000 description 2
- 206010027406 Mesothelioma Diseases 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 239000013614 RNA sample Substances 0.000 description 2
- 108091028664 Ribonucleotide Proteins 0.000 description 2
- 102000005031 SLC6A15 Human genes 0.000 description 2
- 108060007754 SLC6A15 Proteins 0.000 description 2
- 102100031727 Serine incorporator 3 Human genes 0.000 description 2
- 102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 description 2
- 102100031275 UV radiation resistance-associated gene protein Human genes 0.000 description 2
- 108091002660 WAP Four-Disulfide Core Domain Protein 2 Proteins 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 108010076723 adducin Proteins 0.000 description 2
- 102000011759 adducin Human genes 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 231100000504 carcinogenesis Toxicity 0.000 description 2
- 231100000315 carcinogenic Toxicity 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000010835 comparative analysis Methods 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000010219 correlation analysis Methods 0.000 description 2
- 239000005547 deoxyribonucleotide Substances 0.000 description 2
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000003828 downregulation Effects 0.000 description 2
- 208000037828 epithelial carcinoma Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 206010017758 gastric cancer Diseases 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 2
- 230000002962 histologic effect Effects 0.000 description 2
- 238000007901 in situ hybridization Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000000370 laser capture micro-dissection Methods 0.000 description 2
- 238000007834 ligase chain reaction Methods 0.000 description 2
- 230000004758 lung carcinogenesis Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 2
- 230000011987 methylation Effects 0.000 description 2
- 238000007069 methylation reaction Methods 0.000 description 2
- 238000001531 micro-dissection Methods 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 230000001151 other effect Effects 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 229910052704 radon Inorganic materials 0.000 description 2
- SYUHGPGVQRZVTB-UHFFFAOYSA-N radon atom Chemical compound [Rn] SYUHGPGVQRZVTB-UHFFFAOYSA-N 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 239000002336 ribonucleotide Substances 0.000 description 2
- 125000002652 ribonucleotide group Chemical group 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 201000011549 stomach cancer Diseases 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 230000002103 transcriptional effect Effects 0.000 description 2
- 230000005945 translocation Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 238000011179 visual inspection Methods 0.000 description 2
- 102100021408 14-3-3 protein beta/alpha Human genes 0.000 description 1
- 101150098072 20 gene Proteins 0.000 description 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 1
- 102100040023 Adhesion G-protein coupled receptor G6 Human genes 0.000 description 1
- 102100027165 Alpha-2-macroglobulin receptor-associated protein Human genes 0.000 description 1
- 102100034033 Alpha-adducin Human genes 0.000 description 1
- 102100030718 Ankyrin repeat and SOCS box protein 9 Human genes 0.000 description 1
- 102100027765 Atlastin-2 Human genes 0.000 description 1
- 102100027936 Attractin Human genes 0.000 description 1
- 108700003860 Bacterial Genes Proteins 0.000 description 1
- 102100037674 Bis(5'-adenosyl)-triphosphatase Human genes 0.000 description 1
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 description 1
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 description 1
- 102100021411 C-terminal-binding protein 2 Human genes 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 102100039496 Choline transporter-like protein 4 Human genes 0.000 description 1
- 208000031404 Chromosome Aberrations Diseases 0.000 description 1
- 208000037088 Chromosome Breakage Diseases 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 102100035861 Cytosolic 5'-nucleotidase 1A Human genes 0.000 description 1
- 108020005124 DNA Adducts Proteins 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 238000007400 DNA extraction Methods 0.000 description 1
- 238000007399 DNA isolation Methods 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 230000004568 DNA-binding Effects 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 102100021758 E3 ubiquitin-protein transferase MAEA Human genes 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000402754 Erythranthe moschata Species 0.000 description 1
- 101150099271 FHIT gene Proteins 0.000 description 1
- 102100038647 Fibroleukin Human genes 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 102100024421 GTPase IMAP family member 6 Human genes 0.000 description 1
- 102100021223 Glucosidase 2 subunit beta Human genes 0.000 description 1
- 102100025945 Glutaredoxin-1 Human genes 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000818893 Homo sapiens 14-3-3 protein beta/alpha Proteins 0.000 description 1
- 101000959602 Homo sapiens Adhesion G-protein coupled receptor G6 Proteins 0.000 description 1
- 101000836956 Homo sapiens Alpha-2-macroglobulin receptor-associated protein Proteins 0.000 description 1
- 101000799076 Homo sapiens Alpha-adducin Proteins 0.000 description 1
- 101000703112 Homo sapiens Ankyrin repeat and SOCS box protein 9 Proteins 0.000 description 1
- 101000936988 Homo sapiens Atlastin-2 Proteins 0.000 description 1
- 101000697936 Homo sapiens Attractin Proteins 0.000 description 1
- 101001027506 Homo sapiens Bis(5'-adenosyl)-triphosphatase Proteins 0.000 description 1
- 101000889282 Homo sapiens Choline transporter-like protein 4 Proteins 0.000 description 1
- 101000802744 Homo sapiens Cytosolic 5'-nucleotidase 1A Proteins 0.000 description 1
- 101000616009 Homo sapiens E3 ubiquitin-protein transferase MAEA Proteins 0.000 description 1
- 101001031613 Homo sapiens Fibroleukin Proteins 0.000 description 1
- 101000833389 Homo sapiens GTPase IMAP family member 6 Proteins 0.000 description 1
- 101001040875 Homo sapiens Glucosidase 2 subunit beta Proteins 0.000 description 1
- 101000856983 Homo sapiens Glutaredoxin-1 Proteins 0.000 description 1
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 description 1
- 101001010835 Homo sapiens Intraflagellar transport protein 74 homolog Proteins 0.000 description 1
- 101001038435 Homo sapiens Leucine-zipper-like transcriptional regulator 1 Proteins 0.000 description 1
- 101001042362 Homo sapiens Leukemia inhibitory factor receptor Proteins 0.000 description 1
- 101000629081 Homo sapiens MIEF1 upstream open reading frame protein Proteins 0.000 description 1
- 101000956320 Homo sapiens Membrane-spanning 4-domains subfamily A member 6A Proteins 0.000 description 1
- 101000578005 Homo sapiens Mitochondrial dynamics protein MID51 Proteins 0.000 description 1
- 101100080329 Homo sapiens NIPSNAP3B gene Proteins 0.000 description 1
- 101001072590 Homo sapiens POZ-, AT hook-, and zinc finger-containing protein 1 Proteins 0.000 description 1
- 101001060744 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP1A Proteins 0.000 description 1
- 101001091194 Homo sapiens Peptidyl-prolyl cis-trans isomerase G Proteins 0.000 description 1
- 101001095240 Homo sapiens Prolyl endopeptidase-like Proteins 0.000 description 1
- 101000877589 Homo sapiens Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Proteins 0.000 description 1
- 101100476219 Homo sapiens RUNX3 gene Proteins 0.000 description 1
- 101000628562 Homo sapiens Serine/threonine-protein kinase STK11 Proteins 0.000 description 1
- 101000662909 Homo sapiens T cell receptor beta constant 1 Proteins 0.000 description 1
- 101000658398 Homo sapiens T cell receptor beta variable 19 Proteins 0.000 description 1
- 101000979190 Homo sapiens Transcription factor MafB Proteins 0.000 description 1
- 101000795659 Homo sapiens Tuberin Proteins 0.000 description 1
- 101000759233 Homo sapiens Zinc finger protein 140 Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 229930010555 Inosine Natural products 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 102100032818 Integrin alpha-4 Human genes 0.000 description 1
- 102100029997 Intraflagellar transport protein 74 homolog Human genes 0.000 description 1
- 241000764238 Isis Species 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 102100040274 Leucine-zipper-like transcriptional regulator 1 Human genes 0.000 description 1
- 102100021747 Leukemia inhibitory factor receptor Human genes 0.000 description 1
- 102100027033 MIEF1 upstream open reading frame protein Human genes 0.000 description 1
- 241000940612 Medina Species 0.000 description 1
- 102100038555 Membrane-spanning 4-domains subfamily A member 6A Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 101150069768 NTHL1 gene Proteins 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 102100036665 POZ-, AT hook-, and zinc finger-containing protein 1 Human genes 0.000 description 1
- 108091093037 Peptide nucleic acid Proteins 0.000 description 1
- 102100027913 Peptidyl-prolyl cis-trans isomerase FKBP1A Human genes 0.000 description 1
- 102100034850 Peptidyl-prolyl cis-trans isomerase G Human genes 0.000 description 1
- 241000139306 Platt Species 0.000 description 1
- 206010035603 Pleural mesothelioma Diseases 0.000 description 1
- 102100037822 Prolyl endopeptidase-like Human genes 0.000 description 1
- 102100029575 Protein NipSnap homolog 3B Human genes 0.000 description 1
- 102100035480 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Human genes 0.000 description 1
- 238000002123 RNA extraction Methods 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 101000629598 Rattus norvegicus Sterol regulatory element-binding protein 1 Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 102000005032 SLC6A14 Human genes 0.000 description 1
- 108060007753 SLC6A14 Proteins 0.000 description 1
- 101150016669 SORBS2 gene Proteins 0.000 description 1
- 101710181599 Serine/threonine-protein kinase STK11 Proteins 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 102100026901 Sorbin and SH3 domain-containing protein 2 Human genes 0.000 description 1
- 102100037272 T cell receptor beta constant 1 Human genes 0.000 description 1
- 102100034884 T cell receptor beta variable 19 Human genes 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102100023234 Transcription factor MafB Human genes 0.000 description 1
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 1
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 description 1
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 101150042718 Uvrag gene Proteins 0.000 description 1
- 102100023393 Zinc finger protein 140 Human genes 0.000 description 1
- SWPYNTWPIAZGLT-UHFFFAOYSA-N [amino(ethoxy)phosphanyl]oxyethane Chemical compound CCOP(N)OCC SWPYNTWPIAZGLT-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 238000003766 bioinformatics method Methods 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000006369 cell cycle progression Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 108091092356 cellular DNA Proteins 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 231100000244 chromosomal damage Toxicity 0.000 description 1
- 231100000005 chromosome aberration Toxicity 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000002790 cross-validation Methods 0.000 description 1
- 101150052649 ctbp2 gene Proteins 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000002074 deregulated effect Effects 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 230000005782 double-strand break Effects 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 230000036267 drug metabolism Effects 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 239000003596 drug target Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000001819 effect on gene Effects 0.000 description 1
- 238000010218 electron microscopic analysis Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 101150068912 ftrA gene Proteins 0.000 description 1
- 238000003633 gene expression assay Methods 0.000 description 1
- 238000011223 gene expression profiling Methods 0.000 description 1
- 231100000024 genotoxic Toxicity 0.000 description 1
- 230000001738 genotoxic effect Effects 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 238000007417 hierarchical cluster analysis Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000006607 hypermethylation Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000003703 image analysis method Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 210000005033 mesothelial cell Anatomy 0.000 description 1
- 230000031864 metaphase Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 238000010208 microarray analysis Methods 0.000 description 1
- 238000001393 microlithography Methods 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- JTSLALYXYSRPGW-UHFFFAOYSA-N n-[5-(4-cyanophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NC(C1=C2)=CNC1=NC=C2C1=CC=C(C#N)C=C1 JTSLALYXYSRPGW-UHFFFAOYSA-N 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000001558 permutation test Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 208000024356 pleural disease Diseases 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000004952 protein activity Effects 0.000 description 1
- 238000002331 protein detection Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000013441 quality evaluation Methods 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 229910052604 silicate mineral Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 231100000188 sister chromatid exchange Toxicity 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- IBVCSSOEYUMRLC-GABYNLOESA-N texas red-5-dutp Chemical compound O1[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(=O)NC(=O)C(C#CCNS(=O)(=O)C=2C=C(C(C=3C4=CC=5CCCN6CCCC(C=56)=C4OC4=C5C6=[N+](CCC5)CCCC6=CC4=3)=CC=2)S([O-])(=O)=O)=C1 IBVCSSOEYUMRLC-GABYNLOESA-N 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20065032A FI121236B (fi) | 2006-01-18 | 2006-01-18 | Menetelmä asbestialtistukseen liittyvien keuhkosyöpien tunnistamiseksi |
| US12/161,003 US20100279281A1 (en) | 2006-01-18 | 2007-01-18 | Method of identifying lung cancers associated with asbestos-exposure |
| PCT/FI2007/050023 WO2007082998A1 (en) | 2006-01-18 | 2007-01-18 | Method of identifying lung cancers associated with asbestos-exposure |
| JP2008550791A JP2009523436A (ja) | 2006-01-18 | 2007-01-18 | アスベスト被曝に関連した肺癌を同定する方法 |
| EP07700288A EP1977010A4 (en) | 2006-01-18 | 2007-01-18 | METHOD OF IDENTIFYING LUNG CANCER DISORDERS ASSOCIATED WITH ASBEST'S INCOMPACTION WITH |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20065032 | 2006-01-18 | ||
| FI20065032A FI121236B (fi) | 2006-01-18 | 2006-01-18 | Menetelmä asbestialtistukseen liittyvien keuhkosyöpien tunnistamiseksi |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI20065032A0 FI20065032A0 (fi) | 2006-01-18 |
| FI20065032L FI20065032L (fi) | 2007-07-19 |
| FI121236B true FI121236B (fi) | 2010-08-31 |
Family
ID=35883930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI20065032A FI121236B (fi) | 2006-01-18 | 2006-01-18 | Menetelmä asbestialtistukseen liittyvien keuhkosyöpien tunnistamiseksi |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100279281A1 (https=) |
| EP (1) | EP1977010A4 (https=) |
| JP (1) | JP2009523436A (https=) |
| FI (1) | FI121236B (https=) |
| WO (1) | WO2007082998A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108676888B (zh) * | 2018-07-12 | 2022-01-28 | 吉林大学 | 一种肺部恶性肿瘤易感性预测试剂盒及系统 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670314A (en) * | 1994-02-22 | 1997-09-23 | Regents Of The University Of California | Genetic alterations that correlate with lung carcinomas |
| IL159482A0 (en) * | 2001-06-22 | 2004-06-01 | Univ Geneve | Method for detecting diseases caused by chromosomal imbalances |
| WO2003020899A2 (en) * | 2001-08-31 | 2003-03-13 | Diadexus, Inc. | Compositions and methods relating to lung specific genes and proteins |
| CA2527680A1 (en) * | 2003-05-30 | 2005-06-02 | Astrazeneca Uk Limited | Markers for responsiveness to an erbb receptor tyrosine kinase inhibitor |
| CA2554818A1 (en) * | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features |
| AU2006249780A1 (en) * | 2005-05-26 | 2006-11-30 | The Johns Hopkins University | Compositions and methods for the treatment or prevention of chemoresistant neoplasia |
-
2006
- 2006-01-18 FI FI20065032A patent/FI121236B/fi not_active IP Right Cessation
-
2007
- 2007-01-18 WO PCT/FI2007/050023 patent/WO2007082998A1/en not_active Ceased
- 2007-01-18 US US12/161,003 patent/US20100279281A1/en not_active Abandoned
- 2007-01-18 EP EP07700288A patent/EP1977010A4/en not_active Withdrawn
- 2007-01-18 JP JP2008550791A patent/JP2009523436A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1977010A4 (en) | 2009-07-15 |
| WO2007082998A1 (en) | 2007-07-26 |
| JP2009523436A (ja) | 2009-06-25 |
| US20100279281A1 (en) | 2010-11-04 |
| FI20065032A0 (fi) | 2006-01-18 |
| FI20065032L (fi) | 2007-07-19 |
| EP1977010A1 (en) | 2008-10-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7844597B2 (ja) | ヘテロ接合性の消失（ｌｏｓｓ ｏｆ ｈｅｔｅｒｏｚｙｇｏｓｉｔｙ）を評価するための方法および材料 | |
| Helleman et al. | Molecular profiling of platinum resistant ovarian cancer | |
| US9708667B2 (en) | MiRNA expression signature in the classification of thyroid tumors | |
| JP4938672B2 (ja) | ｐ５３の状態と遺伝子発現プロファイルとの関連性に基づき、癌を分類し、予後を予測し、そして診断する方法、システム、およびアレイ | |
| EP2307028B1 (en) | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy | |
| KR101583546B1 (ko) | 유전자 다형성을 이용한 소라페닙 치료에 대한 반응성 예측방법 | |
| US20170166981A1 (en) | Biomarkers and methods of use thereof | |
| EP1824997B1 (en) | Genetic alteration useful for the response prediction of malignant neoplasia to taxane-based medical treatment | |
| KR20080065476A (ko) | 폐암 환자 또는 폐암 치료를 받은 폐암 환자에 대한 폐암재발의 위험을 예측하는 방법, 폐암 환자 또는 폐암 치료를받은 환자의 폐암 재발 위험성에 대한 보고서를 작성하는방법, 그에 의하여 작성된 보고서, 폐암 환자 또는 폐암치료를 받은 폐암 환자의 폐암 재발 위험을 진단하기 위한조성물, 키트 및 마이크로어레이 | |
| WO2007038402A9 (en) | Gene expression profiling for identification of prognostic subclasses in nasopharyngeal carcinomas | |
| EP3143162A1 (en) | Mirna expression signature in the classification of thyroid tumors | |
| Wrage et al. | Identification of HERC 5 and its potential role in NSCLC progression | |
| AU2008225130A1 (en) | Methods of determining acute myeloid leukemia response to treatment with farnesyltransferase | |
| Enomoto et al. | Lack of association between CpG island methylator phenotype in human gastric cancers and methylation in their background non‐cancerous gastric mucosae | |
| Dierlamm et al. | Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma | |
| Chen et al. | Genetic variants of MGMT, RHPN 2, and FAM 49A contributed to susceptibility of nonsyndromic orofacial clefts in a Chinese population | |
| JP2005524388A (ja) | パクリタキセル応答性予測の一塩基多型及びそれらの組合せ | |
| WO2007058623A1 (en) | Methods of predicting hepatocellular carcinoma recurrence by the determination of hepatocellular carcinoma recurrence-associated molecular biomarkers | |
| WO2022221566A1 (en) | Methods and kits for identifying subjects responsive to arginine deprivation therapy | |
| EP2494067A1 (en) | Method for the prognosis of ovarian carcinoma | |
| US20080003603A1 (en) | Human melanoma mutation | |
| FI121236B (fi) | Menetelmä asbestialtistukseen liittyvien keuhkosyöpien tunnistamiseksi | |
| EP2630259B1 (en) | Signatures of clinical outcome in gastro intestinal stromal tumors and method of treatment of gastroinstestinal stromal tumors | |
| EP3050975A1 (en) | Method for predicting the response to chemotherapy treatment in patients suffering from colorectal cancer | |
| EP3201358A1 (en) | Markers of poor prognosis acute myeloid leukemias (amls) and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Ref document number: 121236 Country of ref document: FI |
|
| MM | Patent lapsed |