FI107053B - I nogalamycinbiosyntes ingående genkluster och dess användning vid producering av hybridantibiotika - Google Patents

I nogalamycinbiosyntes ingående genkluster och dess användning vid producering av hybridantibiotika Download PDF

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Publication number
FI107053B
FI107053B FI982295A FI982295A FI107053B FI 107053 B FI107053 B FI 107053B FI 982295 A FI982295 A FI 982295A FI 982295 A FI982295 A FI 982295A FI 107053 B FI107053 B FI 107053B
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FI
Finland
Prior art keywords
leu
arg
gly
ala
pro
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Application number
FI982295A
Other languages
English (en)
Finnish (fi)
Other versions
FI982295A0 (sv
FI982295A (sv
Inventor
Juha Hakala
Kristiina Ylihonko
Kaisa Palmu
Sirke Torkkell
Original Assignee
Galilaeus Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Galilaeus Oy filed Critical Galilaeus Oy
Priority to FI982295A priority Critical patent/FI107053B/sv
Publication of FI982295A0 publication Critical patent/FI982295A0/sv
Priority to PCT/FI1999/000870 priority patent/WO2000024775A1/en
Priority to EP99952669A priority patent/EP1123310A1/en
Priority to JP2000578345A priority patent/JP2002528068A/ja
Publication of FI982295A publication Critical patent/FI982295A/sv
Application granted granted Critical
Publication of FI107053B publication Critical patent/FI107053B/sv

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI982295A 1998-10-23 1998-10-23 I nogalamycinbiosyntes ingående genkluster och dess användning vid producering av hybridantibiotika FI107053B (sv)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FI982295A FI107053B (sv) 1998-10-23 1998-10-23 I nogalamycinbiosyntes ingående genkluster och dess användning vid producering av hybridantibiotika
PCT/FI1999/000870 WO2000024775A1 (en) 1998-10-23 1999-10-20 Gene cluster involved in nogalamycin biosynthesis, and its use in production of hybrid antibiotics
EP99952669A EP1123310A1 (en) 1998-10-23 1999-10-20 Gene cluster involved in nogalamycin biosynthesis, and its use in production of hybrid antibiotics
JP2000578345A JP2002528068A (ja) 1998-10-23 1999-10-20 ノガラマイシン生合成に関与する遺伝子クラスター、およびハイブリッド抗生物質の製造におけるその使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI982295A FI107053B (sv) 1998-10-23 1998-10-23 I nogalamycinbiosyntes ingående genkluster och dess användning vid producering av hybridantibiotika
FI982295 1998-10-23

Publications (3)

Publication Number Publication Date
FI982295A0 FI982295A0 (sv) 1998-10-23
FI982295A FI982295A (sv) 2000-04-24
FI107053B true FI107053B (sv) 2001-05-31

Family

ID=8552767

Family Applications (1)

Application Number Title Priority Date Filing Date
FI982295A FI107053B (sv) 1998-10-23 1998-10-23 I nogalamycinbiosyntes ingående genkluster och dess användning vid producering av hybridantibiotika

Country Status (4)

Country Link
EP (1) EP1123310A1 (sv)
JP (1) JP2002528068A (sv)
FI (1) FI107053B (sv)
WO (1) WO2000024775A1 (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI111270B (sv) * 2001-03-19 2003-06-30 Galilaeus Oy Genkluster för biosyntes av angucyklin och dess användning för generering av kompositioner för läkemedelscreening
ES2644422T3 (es) 2007-05-08 2017-11-28 Provivo Oy Cepas modificadas genéticamente que producen metabolitos de antraciclina útiles como fármacos para el cáncer
EP2766389B1 (en) 2011-10-12 2017-03-29 Sanofi Gene cluster for biosynthesis of griselimycin and methylgriselimycin
EP2586791A1 (en) * 2011-10-28 2013-05-01 Sanofi Gene cluster for biosynthesis of griselimycin and methylgriselimycin
CN110713992B (zh) * 2019-11-07 2021-08-03 凯莱英医药化学（阜新）技术有限公司 酮还原酶突变体及生产手性醇的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI944556A0 (fi) * 1994-09-30 1994-09-30 Kristiina Ylihonko Foerfarande foer producering av antracykliner och deras mellanprodukter

Also Published As

Publication number Publication date
WO2000024775A1 (en) 2000-05-04
FI982295A0 (sv) 1998-10-23
FI982295A (sv) 2000-04-24
EP1123310A1 (en) 2001-08-16
WO2000024775A9 (en) 2000-08-24
JP2002528068A (ja) 2002-09-03

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