FI102811B1 - Förfarande för framställning av aktiva substanser innehållande mikropartiklar av hydrolytiskt nedbrytbara polymerer - Google Patents

Förfarande för framställning av aktiva substanser innehållande mikropartiklar av hydrolytiskt nedbrytbara polymerer

Info

Publication number
FI102811B1
FI102811B1 FI932761A FI932761A FI102811B1 FI 102811 B1 FI102811 B1 FI 102811B1 FI 932761 A FI932761 A FI 932761A FI 932761 A FI932761 A FI 932761A FI 102811 B1 FI102811 B1 FI 102811B1
Authority
FI
Finland
Prior art keywords
pct
active substances
preparation
substances containing
degradable polymers
Prior art date
Application number
FI932761A
Other languages
English (en)
Finnish (fi)
Other versions
FI102811B (sv
FI932761A0 (fi
FI932761A (fi
Inventor
Heike Biskup
Elke Gorissen
Hannelore Schneider
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of FI932761A0 publication Critical patent/FI932761A0/fi
Publication of FI932761A publication Critical patent/FI932761A/fi
Application granted granted Critical
Publication of FI102811B1 publication Critical patent/FI102811B1/sv
Publication of FI102811B publication Critical patent/FI102811B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyamides (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Saccharide Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
FI932761A 1990-12-22 1993-06-16 Förfarande för framställning av aktiva substanser innehållande mikropa rtiklar av hydrolytiskt nedbrytbara polymerer FI102811B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4041563A DE4041563A1 (de) 1990-12-22 1990-12-22 Verfahren zur herstellung wirkstoffhaltiger mikropartikel aus hydrolytisch abbaubaren polymeren
DE4041563 1990-12-22
PCT/DE1991/001002 WO1992011000A1 (de) 1990-12-22 1991-12-18 Verfahren zur herstellung wirkstoffhaltiger mikropartikel aus hydrolytisch abbaubaren polymeren
DE9101002 1991-12-18

Publications (4)

Publication Number Publication Date
FI932761A0 FI932761A0 (fi) 1993-06-16
FI932761A FI932761A (fi) 1993-06-16
FI102811B1 true FI102811B1 (sv) 1999-02-26
FI102811B FI102811B (sv) 1999-02-26

Family

ID=6421280

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932761A FI102811B (sv) 1990-12-22 1993-06-16 Förfarande för framställning av aktiva substanser innehållande mikropa rtiklar av hydrolytiskt nedbrytbara polymerer

Country Status (15)

Country Link
US (1) US5424076A (sv)
EP (1) EP0563176B1 (sv)
JP (1) JP3496153B2 (sv)
KR (1) KR0162105B1 (sv)
AT (1) ATE116542T1 (sv)
CA (1) CA2098814C (sv)
DE (2) DE4041563A1 (sv)
DK (1) DK0563176T3 (sv)
ES (1) ES2067324T3 (sv)
FI (1) FI102811B (sv)
GR (1) GR3015623T3 (sv)
HU (1) HU217817B (sv)
IE (1) IE65915B1 (sv)
PT (1) PT99892B (sv)
WO (1) WO1992011000A1 (sv)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
US6169763B1 (en) 1995-06-29 2001-01-02 Qualcomm Inc. Characterizing a communication system using frame aligned test signals
FR2753639B1 (fr) * 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
US5766637A (en) * 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
DE19711393C1 (de) * 1997-03-19 1998-08-13 Fraunhofer Ges Forschung Verfahren zum Mikroverkapseln von Partikeln
AR012448A1 (es) 1997-04-18 2000-10-18 Ipsen Pharma Biotech Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada
FR2762318B1 (fr) * 1997-04-18 1999-09-17 Pharma Biotech Compositions presentant une liberation prolongee et leur procede de preparation
FR2776516B1 (fr) * 1998-03-25 2001-05-25 Pharma Biotech Compositions presentant une liberation prolongee et leur procede de preparation
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
GB9915975D0 (en) 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
WO2001003671A2 (de) * 1999-07-13 2001-01-18 Skw Trostberg Aktiengesellschaft Verfahren zur herstellung pulverförmiger partikelreduzierter formulierungen mit hilfe verdichteter gase
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
FR2811913B1 (fr) * 2000-07-19 2003-09-19 Separex Sa Procede d'encapsulation sous forme de micro-capsules de fines particules solides
US6579532B1 (en) * 2000-09-08 2003-06-17 Ferro Corporation Orthopedic mixtures prepared by supercritical fluid processing techniques
US6521258B1 (en) * 2000-09-08 2003-02-18 Ferro Corporation Polymer matrices prepared by supercritical fluid processing techniques
GB0027357D0 (en) * 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
US7582284B2 (en) * 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US6966990B2 (en) * 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
US20040185110A1 (en) * 2002-11-08 2004-09-23 Ronald Harland Formulations of low solubility bioactive agents and processes for making the same
CA2524773C (en) 2003-05-08 2014-04-08 Nektar Therapeutics Uk Ltd Particulate coformulations of active substances with excipients
US7507823B2 (en) * 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
EP1757361A1 (en) * 2005-08-23 2007-02-28 Feyecon Development & Implementation B.V. Process for the preparation of encapsulates through precipitation
WO2008070279A2 (en) * 2006-10-11 2008-06-12 Crititech, Inc. Method for precipitation of small medicament particles into use containers
ES2691033T3 (es) 2007-02-11 2018-11-23 Map Pharmaceuticals Inc. Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios
EP2170284B1 (en) * 2007-07-18 2011-08-24 Feyecon B.V. A method of preparing a pharmaceutical co-crystal composition
WO2009110939A2 (en) * 2007-12-10 2009-09-11 Massachusetts Institute Of Technology Drug delivery system for pharmaceuticals and radiation
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
DE3218151A1 (de) * 1982-05-14 1983-11-17 Akzo Gmbh, 5600 Wuppertal Mikroporoese, pulverfoermige polylactide und verfahren zu deren herstellung
CA1241246A (en) * 1983-07-21 1988-08-30 Salomon Hakim Surgically-implantable device susceptible of noninvasive magnetic adjustment
CH666406A5 (de) * 1984-02-29 1988-07-29 Sandoz Ag Verfahren zur herstellung von mikrokapseln, welche bromokriptinmesylat als pharmakologischen wirkstoff enthalten.
HU192982B (en) * 1984-04-28 1987-08-28 Allatorvostudomanyi Egyetem Process for producing synergetic pharmaceutical compositions containing thiamulin and antibacterial and antiprotozoal organic acids
DE3428372A1 (de) * 1984-08-01 1986-02-13 Hoechst Ag, 6230 Frankfurt Mikrokapseln von regulatorischen peptiden mit kontrollierter freisetzung, verfahren zu ihrer herstellung und injektionszubereitungen
DE3701625A1 (de) * 1987-01-21 1988-08-04 Boehringer Ingelheim Kg Perorale arzneimittelzubereitung mit verzoegerter wirkstofffreigabe
DE3738228A1 (de) * 1987-11-11 1989-05-24 Hoechst Ag Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln
DE3744329A1 (de) * 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
JP2827287B2 (ja) * 1988-07-05 1998-11-25 武田薬品工業株式会社 水溶性薬物含有徐放型マイクロカプセル
US5271945A (en) * 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
DE69005800T2 (de) * 1989-05-01 1994-05-19 Alkermes Inc Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekülen.
DE3917617A1 (de) * 1989-05-31 1990-12-06 Boehringer Ingelheim Kg Mikronisierte bioabbaubare partikel, verfahren zur ihrer herstellung und ihre verwendung
CA2020755A1 (en) * 1989-07-10 1991-01-11 David M. Lokensgard Solvent extraction process
US5232707A (en) * 1989-07-10 1993-08-03 Syntex (U.S.A.) Inc. Solvent extraction process
GB8928250D0 (en) * 1989-12-14 1990-02-21 Erba Carlo Spa Use of supercritical fluids to obtain porous sponges of biodegradable polymers

Also Published As

Publication number Publication date
PT99892B (pt) 1999-06-30
WO1992011000A1 (de) 1992-07-09
JPH06504531A (ja) 1994-05-26
CA2098814C (en) 1999-05-11
HU9301812D0 (en) 1993-09-28
IE65915B1 (en) 1995-11-29
FI102811B (sv) 1999-02-26
EP0563176A1 (en) 1993-10-06
DE4041563A1 (de) 1992-06-25
KR930701985A (ko) 1993-09-08
JP3496153B2 (ja) 2004-02-09
DK0563176T3 (da) 1995-03-06
EP0563176B1 (de) 1995-01-04
CA2098814A1 (en) 1992-06-23
GR3015623T3 (en) 1995-06-30
DE59104172D1 (de) 1995-02-16
KR0162105B1 (ko) 1998-12-01
IE914313A1 (en) 1992-07-01
HUT63954A (en) 1993-11-29
ES2067324T3 (es) 1995-03-16
PT99892A (pt) 1992-12-31
ATE116542T1 (de) 1995-01-15
US5424076A (en) 1995-06-13
FI932761A0 (fi) 1993-06-16
FI932761A (fi) 1993-06-16
HU217817B (hu) 2000-04-28

Similar Documents

Publication Publication Date Title
FI102811B1 (sv) Förfarande för framställning av aktiva substanser innehållande mikropartiklar av hydrolytiskt nedbrytbara polymerer
NO20002788D0 (no) Nye forbindelser
DE122007000024I1 (de) Verfahren zur Herstellung von gasgef}llten Lipid-mikropartikeln und gasgef}llte Lipid-mikroartikel
DE69520036D1 (de) Verfahren zur herstellung von festen pharmazeutischen dosierungsformen hydrophobischen substanzen
DK0540670T3 (da) Fremgangsmåde til fremstilling af tværbundne polyaminer
KR930021061A (ko) 살충방법
GEP20022707B (en) Biodegrading Macromers for the Controlled Release of Biologically Active Substances
DE69531741D1 (de) Verbindungen und zusammensetzungen zur verabreichung aktiver stoffe
KR100263555B1 (sv)
DE69429048D1 (de) Biologisch erodierbare Vorrichtung zur Verabreichung von Wirkstoffen
ATE179886T1 (de) Pharmazeutische zusammensetzung mit einem schmelzbaren traegermaterial und verfahren zu seiner herstellung
ID21682A (id) Turunan-turunan pirolo [3,4-d] pirimidinon dan penggunaannya sebagai obat-obatan
IL115138A0 (en) Implantable polymer-containing molded articles for the administration of active substances to plants and processes for the preparation thereof
DE69527711D1 (de) Verfahren und apparat zur herstellung von schnelllöslichen dosierungseinheiten und daraus erhältliches produkt
HUP9802498A2 (hu) Eljárás és berendezés hatóanyagoknak valamely szűrőanyagra történő felhordására
DE60045411D1 (de) Verfahren und vorrichtung zur herstellung von filterstäben mit partikeln
DE59703693D1 (de) Pflanzenbehandlungsmittel
ATE196404T1 (de) Implantierbare vorrichtung zur verabreichung von wirkstoffen an pflanzen
DE69306390D1 (de) Zusammenfassung zur kontrollierten abgabe eines wirkstoffes und verfahren zur herstellung derselbe
IE900226L (en) Moulded bodies for plant culture
DE69623652D1 (de) Formulierung zur peptidfreisetzung
FR2454804A1 (fr) Medicament a base de dihydroergotoxine et son procede de preparation
PL315619A1 (en) Oral form of a drug containing acid active substances and method of obtaining same
UA10281C2 (uk) Спосіб отримання речовини для лікування захворювань підшлункової залози

Legal Events

Date Code Title Description
MA Patent expired