ES8802144A1 - Un procedimiento para la preparacion de derivados de fenotiazinas. - Google Patents

Un procedimiento para la preparacion de derivados de fenotiazinas.

Info

Publication number
ES8802144A1
ES8802144A1 ES536525A ES536525A ES8802144A1 ES 8802144 A1 ES8802144 A1 ES 8802144A1 ES 536525 A ES536525 A ES 536525A ES 536525 A ES536525 A ES 536525A ES 8802144 A1 ES8802144 A1 ES 8802144A1
Authority
ES
Spain
Prior art keywords
6alkyl
phenyl
hydrogen
substituted
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536525A
Other languages
English (en)
Other versions
ES536525A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Publication of ES8802144A1 publication Critical patent/ES8802144A1/es
Publication of ES536525A0 publication Critical patent/ES536525A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/30—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with acyl radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/34—[b, e]-condensed with two six-membered rings with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE FENOTIAZINAS. LAS FENOTIAZINAS (I), DONDE NO EXHAUSTIVAMENTE, R1 ES H O CH3, R2 ES H O 2-OME, R3 ES 4-X CON X F CL O BR, R4 ES H, 7-F O 7-OME, R ES H Y T ES 3-OH; SE PREPARAN POR A) REACCION DE UNA BENZOQUINONA (II) CON UN 2-AMINOBENZOL (III), EN UN DISOLVENTE ADECUADO, TIPO METANOL, EN UN INTERVALO ENTRE C20 Y 60JC, DESPUES B) SE HALOGENA EN PRESENCIA DE UN ACIDO ALCANOICO, COMO EL ACETICO; TRAS LO CUAL C) SE REDUCE, DENTRO DE DISOLVENTE ADECUADO, ENTRE 10 Y 50JC PARA DESPUES; D) HACER REACCIONAR CON ANHIDRIDO, E) CON HALURO DE ALQUILO O ACILO Y FINALMENTE F) HIDROLIZAR CON UNA BASE. COMO INHIBIDORES DE LA BIOSINTESIS DE LEUCOTRIENOS EN MAMIFEROS, SON AGENTES TERAPEUTICOS UTILES EN EL TRATAMIENTO DE LAS CONDICIONES ALERGICAS, ASMA, TRASTORNOS CARDIOVASCULARES E INFLAMACIONES, Y COMO AGENTES CITOPROTECTORES.
ES536525A 1983-10-05 1984-10-04 Un procedimiento para la preparacion de derivados de fenotiazinas. Expired ES8802144A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53934283A 1983-10-05 1983-10-05

Publications (2)

Publication Number Publication Date
ES8802144A1 true ES8802144A1 (es) 1988-04-01
ES536525A0 ES536525A0 (es) 1988-04-01

Family

ID=24150810

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536525A Expired ES8802144A1 (es) 1983-10-05 1984-10-04 Un procedimiento para la preparacion de derivados de fenotiazinas.

Country Status (6)

Country Link
EP (1) EP0138481B1 (es)
JP (1) JPS60155165A (es)
CA (1) CA1272722A (es)
DE (1) DE3484745D1 (es)
DK (1) DK475684A (es)
ES (1) ES8802144A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1309557C (en) 1985-06-18 1992-10-27 Robert N. Young Leukotriene antagonists
DE3526566A1 (de) * 1985-07-25 1987-02-05 Boehringer Mannheim Gmbh N-acyl-dihydroresorufin-derivate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung von wasserstoffperoxid, peroxidatisch wirkender verbindungen oder peroxidase
EP0239306B1 (en) 1986-03-27 1993-06-02 Merck Frosst Canada Inc. Tetrahydrocarbazole esters
US4707473A (en) * 1986-05-30 1987-11-17 Syntex (U.S.A.) Inc. 4-monosubstituted and 4,6-disubstituted phenoxazines
US4803269A (en) * 1986-05-30 1989-02-07 Syntex (U.S.A.) Inc. 4-monosubstituted and 4,6-disubstituted N-(α-phenylethyl)phenoxazines
CA2053216C (en) 1990-10-12 2003-04-08 Michel L. Belley Saturated hydroxyalkylquinoline acids as leukotriene antagonists
US5410054A (en) * 1993-07-20 1995-04-25 Merck Frosst Canada, Inc. Heteroaryl quinolines as inhibitors of leukotriene biosynthesis
US6333322B1 (en) 1996-03-13 2001-12-25 Eisai Co., Ltd. Nitrogen-containing tricyclic compounds and drugs containing the same
EP1057830A4 (en) * 1998-02-27 2001-09-19 Eisai Co Ltd HETEROCYCLIC CONDENSED BENZOTHIAZINE DERIVATIVES
CA2310205A1 (en) * 2000-05-29 2001-11-29 Dalhousie University Unknown
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
NZ567711A (en) * 2001-06-11 2009-10-30 Xenoport Inc Orally administered dosage forms of GABA analog prodrugs having reduced toxicity
US7432372B2 (en) 2003-10-31 2008-10-07 Invitrogen Corporation Fluorinated resorufin compounds and their application
KR101228399B1 (ko) 2004-11-04 2013-01-31 제노포트 인코포레이티드 가바펜틴 프로드러그 서방성 경구 투여 형태
WO2011093443A1 (ja) * 2010-01-29 2011-08-04 日本ゼオン株式会社 縮合複素環化合物及び組成物
US8609753B2 (en) * 2010-01-29 2013-12-17 Zeon Corporation Acrylic rubber composition and cross-linked rubber product
TW201236239A (en) * 2010-11-16 2012-09-01 Solvay Rechargeable metal or metal-ion cell
EP3473254B1 (en) * 2011-08-02 2024-01-24 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Phenothiazine derivatives for the treatment of autoimmune diseases
US9296712B2 (en) 2013-03-15 2016-03-29 Edison Pharmaceuticals, Inc. Resorufin derivatives for treatment of oxidative stress disorders
US9868711B2 (en) 2013-03-15 2018-01-16 Bioelectron Technology Corporation Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US9670170B2 (en) 2013-03-15 2017-06-06 Bioelectron Technology Corporation Resorufin derivatives for treatment of oxidative stress disorders
CN114213359B (zh) * 2022-01-12 2023-07-25 郑州大学 一种合成1-羟基吩噻嗪类化合物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58225093A (ja) * 1982-06-25 1983-12-27 Kanegafuchi Chem Ind Co Ltd ベンゾチアジノリフアマイシン誘導体およびその製造法
DE3229122A1 (de) * 1982-08-04 1984-02-09 Bayer Ag, 5090 Leverkusen Anellierte 4h-1,4-benzothiazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
NZ206795A (en) * 1983-01-21 1987-08-31 Merck Frosst Canada Inc Phenothiazines, analogues and pharmaceutical compositions
DE3479397D1 (en) * 1983-10-05 1989-09-21 Merck Frosst Canada Inc Benzoûa¨phenothiazines and hydro-derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE3484745D1 (de) 1991-08-01
EP0138481A3 (en) 1987-04-01
JPS60155165A (ja) 1985-08-15
DK475684D0 (da) 1984-10-04
CA1272722A (en) 1990-08-14
EP0138481B1 (en) 1991-06-26
ES536525A0 (es) 1988-04-01
EP0138481A2 (en) 1985-04-24
DK475684A (da) 1985-04-06

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