ES8801927A1 - Procedimiento para preparar una antraciclinona - Google Patents

Procedimiento para preparar una antraciclinona

Info

Publication number
ES8801927A1
ES8801927A1 ES557789A ES557789A ES8801927A1 ES 8801927 A1 ES8801927 A1 ES 8801927A1 ES 557789 A ES557789 A ES 557789A ES 557789 A ES557789 A ES 557789A ES 8801927 A1 ES8801927 A1 ES 8801927A1
Authority
ES
Spain
Prior art keywords
group
tetralins
denote
och3
anthracyclins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557789A
Other languages
English (en)
Other versions
ES557789A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Laboratoires Hoechst SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Hoechst SA filed Critical Laboratoires Hoechst SA
Publication of ES8801927A1 publication Critical patent/ES8801927A1/es
Publication of ES557789A0 publication Critical patent/ES557789A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

UNA TETRALINA, DE FORMULA GENERAL (II), SE TRANSFORMA, POR OXIDACION ANODICA, EN UN MONOACETAL DE QUINONA DE FORMULA (III), DONDE TBDMS SIGNIFICA TERC-BUTILDIMETILSILILILO, EFECTUANDOSE A CONTINUACION UNA HIDROLISIS SELECTIVA Y OBTENIENDOSE FINALMENTE UNA ANTRACICLINONA DE FORMULA (I) EN DONDE R ES HIDROGENO O UN GRUPO PROTECTOR DE HIDROXILO. EN (II), R1 Y R2 DESIGNAN UN ATOMO DE HIDROGENO O UN ATOMO DE HALOGENO O EL GRUPO OCH3, DEBIENDO SER AL MENOS UNO DE LOS DOS SUSTITUYENTES R1 O R2 EL GRUPO OCH3, Y R3 DESIGNA UN ATOMO DE HIDROGENO O EL GRUPO ORK, DONDE RK ES HIDROGENO O UN GRUPO PROTECTOR DE HIDROXILO. SE DESCRIBE EL EFECTO SOBRE CELULAS DE LEUCEMIA L1210. DE APLICACION EN LA OBTENCION DE ANTRACICLINAS DE ALTO VALOR TERAPEUTICO, CON ACTIVIDAD ANTITUMORAL.
ES557789A 1985-07-02 1987-12-16 Procedimiento para preparar una antraciclinona Expired ES8801927A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8510063A FR2584406B1 (fr) 1985-07-02 1985-07-02 Nouvelles tetralines, leurs procedes de preparation, leur utilisation pour la preparation des anthracyclinones et nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones

Publications (2)

Publication Number Publication Date
ES8801927A1 true ES8801927A1 (es) 1988-03-01
ES557789A0 ES557789A0 (es) 1988-03-01

Family

ID=9320868

Family Applications (4)

Application Number Title Priority Date Filing Date
ES556755A Expired ES8707484A1 (es) 1985-07-02 1986-06-25 Un procedimiento para preparar nuevas tetralinas
ES557462A Expired ES8802525A1 (es) 1985-07-02 1987-03-20 Procedimiento para preparar una antraciclinona
ES557788A Expired ES8801926A1 (es) 1985-07-02 1987-12-16 Procedimiento para preparar una antraciclinona
ES557789A Expired ES8801927A1 (es) 1985-07-02 1987-12-16 Procedimiento para preparar una antraciclinona

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES556755A Expired ES8707484A1 (es) 1985-07-02 1986-06-25 Un procedimiento para preparar nuevas tetralinas
ES557462A Expired ES8802525A1 (es) 1985-07-02 1987-03-20 Procedimiento para preparar una antraciclinona
ES557788A Expired ES8801926A1 (es) 1985-07-02 1987-12-16 Procedimiento para preparar una antraciclinona

Country Status (11)

Country Link
US (1) US4918173A (es)
EP (1) EP0207424B1 (es)
JP (1) JPS6216496A (es)
AT (1) ATE70836T1 (es)
AU (2) AU594689B2 (es)
DE (1) DE3683090D1 (es)
DK (1) DK312486A (es)
ES (4) ES8707484A1 (es)
FR (1) FR2584406B1 (es)
GR (1) GR861693B (es)
PT (1) PT82898B (es)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1542920A (en) * 1976-12-22 1979-03-28 Farmaceutici Italia Antitumour glycosides
US4316985A (en) * 1979-01-16 1982-02-23 Hoffmann-La Roche Inc. Cyclic compounds
FR2454445A1 (fr) * 1979-10-11 1980-11-14 Erba Farmitalia Anthracyclines anti-tumeurs
US4374979A (en) * 1981-04-27 1983-02-22 The University Of Kansas Endowment Association Regiospecific synthesis of anthracyclinone compounds such as daunomycinone
AU554416B2 (en) * 1982-05-24 1986-08-21 Farmitalia Carlo Erba S.P.A. Anthracycline glycosides
FR2560876B1 (fr) * 1984-03-09 1987-01-16 Hoechst Lab Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments
EP0368866A1 (en) * 1987-05-15 1990-05-23 Schering Corporation Aryl substituted naphthalene, benzoxepine, benzazepine, benzocycloheptene derivatives

Also Published As

Publication number Publication date
ES8801926A1 (es) 1988-03-01
ES557462A0 (es) 1988-07-01
DE3683090D1 (en) 1992-02-06
AU5944086A (en) 1987-01-08
ATE70836T1 (de) 1992-01-15
US4918173A (en) 1990-04-17
DK312486D0 (da) 1986-07-01
PT82898B (pt) 1989-01-30
GR861693B (en) 1986-10-30
PT82898A (en) 1986-08-01
ES557789A0 (es) 1988-03-01
ES8802525A1 (es) 1988-07-01
DK312486A (da) 1987-01-03
EP0207424B1 (en) 1991-12-27
EP0207424A3 (en) 1987-10-28
JPS6216496A (ja) 1987-01-24
ES556755A0 (es) 1987-08-01
FR2584406B1 (fr) 1988-09-09
AU3645789A (en) 1989-11-09
AU594689B2 (en) 1990-03-15
EP0207424A2 (en) 1987-01-07
ES8707484A1 (es) 1987-08-01
FR2584406A1 (fr) 1987-01-09
AU614383B2 (en) 1991-08-29
ES557788A0 (es) 1988-03-01

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