FR2454445A1 - Anthracyclines anti-tumeurs - Google Patents

Anthracyclines anti-tumeurs

Info

Publication number
FR2454445A1
FR2454445A1 FR8015784A FR8015784A FR2454445A1 FR 2454445 A1 FR2454445 A1 FR 2454445A1 FR 8015784 A FR8015784 A FR 8015784A FR 8015784 A FR8015784 A FR 8015784A FR 2454445 A1 FR2454445 A1 FR 2454445A1
Authority
FR
France
Prior art keywords
daunomycinone
methoxy
trifluoroacetyl
treatment
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR8015784A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of FR2454445A1 publication Critical patent/FR2454445A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

GLYCOSIDES D'ANTHRACYCLINES ANTI-TUMEURS AYANT LA FORMULE GENERALE I. (CF DESSIN DANS BOPI) DANS LAQUELLE X REPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE HYDROXY, R UN ATOME D'HYDROGENE OU UN GROUPE ALKYLE OU ARYLE, R REPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE TRIFLUOROACETYLE. CES COMPOSES SONT PREPARES EN INTRODUISANT, AU MOYEN D'UNE SERIE DE REACTIONS APPROPRIEES, UN GROUPE HYDROXY EN POSITION 8 DANS LA DAUNOMYCINONE CONNUE, EVENTUELLEMENT EN ALKYLANT OU EN ARYLATANT LE GROUPE 8 HYDROXYLE, EN CONDENSANT LES NOUVEAUX AGLICONES OBTENUS AVEC DE LA 1-CHLORO-N, 0-TRIFLUOROACETYL-DAUNOSAMINE, EN ENLEVANT TOUT GROUPE PROTECTEUR DES NOUVEAUX GLYCOSIDES AINSI FORMES, PAR TRAITEMENT ALCALIN DOUX ET, EVENTUELLEMENT, EN TRANSFORMANT LE GROUPE 9-ACETYLE DES COMPOSES OBTENUS EN UN GROUPE 9-HYDROXY-ACETYLE PAR BROMATION ET HYDROLYSE.
FR8015784A 1979-10-11 1980-07-17 Anthracyclines anti-tumeurs Withdrawn FR2454445A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7935335 1979-10-11

Publications (1)

Publication Number Publication Date
FR2454445A1 true FR2454445A1 (fr) 1980-11-14

Family

ID=10508433

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8015784A Withdrawn FR2454445A1 (fr) 1979-10-11 1980-07-17 Anthracyclines anti-tumeurs

Country Status (3)

Country Link
JP (1) JPS5661400A (fr)
DE (1) DE3028341A1 (fr)
FR (1) FR2454445A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2560876A1 (fr) * 1984-03-09 1985-09-13 Hoechst Lab Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments
EP0207424A2 (fr) * 1985-07-02 1987-01-07 Laboratoires Hoechst S.A. Anthracyclines
US5412081A (en) * 1989-02-07 1995-05-02 Farmitalia Carlo Erba S.R.L. New 4'-epi-4'-amino anthracyclines

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0522075Y2 (fr) * 1987-07-17 1993-06-07

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2560876A1 (fr) * 1984-03-09 1985-09-13 Hoechst Lab Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments
EP0156172A2 (fr) * 1984-03-09 1985-10-02 Laboratoires Hoechst S.A. Méthode de préparation d'anthracyclinones
EP0156172A3 (fr) * 1984-03-09 1986-04-16 Laboratoires Hoechst S.A. Méthode de préparation d'anthracyclinones
EP0207424A2 (fr) * 1985-07-02 1987-01-07 Laboratoires Hoechst S.A. Anthracyclines
FR2584406A1 (fr) * 1985-07-02 1987-01-09 Hoechst Lab Nouvelles tetralines, leurs procedes de preparation, leur utilisation pour la preparation des anthracyclinones et nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones
EP0207424A3 (en) * 1985-07-02 1987-10-28 Laboratoires Hoechst S.A. New tetralins, processes for their preparation, their use for the preparation of anthracyclinones and new glycosides (anthracyclins) obtained from these anthracyclinones
US5412081A (en) * 1989-02-07 1995-05-02 Farmitalia Carlo Erba S.R.L. New 4'-epi-4'-amino anthracyclines

Also Published As

Publication number Publication date
DE3028341A1 (de) 1981-04-23
JPS5661400A (en) 1981-05-26

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Legal Events

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