ES557789A0 - Procedimiento para preparar una antraciclinona - Google Patents
Procedimiento para preparar una antraciclinonaInfo
- Publication number
- ES557789A0 ES557789A0 ES557789A ES557789A ES557789A0 ES 557789 A0 ES557789 A0 ES 557789A0 ES 557789 A ES557789 A ES 557789A ES 557789 A ES557789 A ES 557789A ES 557789 A0 ES557789 A0 ES 557789A0
- Authority
- ES
- Spain
- Prior art keywords
- sub
- group
- tetralins
- denote
- anthraciclinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 abstract 1
- 150000002338 glycosides Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8510063A FR2584406B1 (fr) | 1985-07-02 | 1985-07-02 | Nouvelles tetralines, leurs procedes de preparation, leur utilisation pour la preparation des anthracyclinones et nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8801927A1 ES8801927A1 (es) | 1988-03-01 |
| ES557789A0 true ES557789A0 (es) | 1988-03-01 |
Family
ID=9320868
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES556755A Expired ES8707484A1 (es) | 1985-07-02 | 1986-06-25 | Un procedimiento para preparar nuevas tetralinas |
| ES557462A Expired ES8802525A1 (es) | 1985-07-02 | 1987-03-20 | Procedimiento para preparar una antraciclinona |
| ES557788A Expired ES8801926A1 (es) | 1985-07-02 | 1987-12-16 | Procedimiento para preparar una antraciclinona |
| ES557789A Expired ES8801927A1 (es) | 1985-07-02 | 1987-12-16 | Procedimiento para preparar una antraciclinona |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES556755A Expired ES8707484A1 (es) | 1985-07-02 | 1986-06-25 | Un procedimiento para preparar nuevas tetralinas |
| ES557462A Expired ES8802525A1 (es) | 1985-07-02 | 1987-03-20 | Procedimiento para preparar una antraciclinona |
| ES557788A Expired ES8801926A1 (es) | 1985-07-02 | 1987-12-16 | Procedimiento para preparar una antraciclinona |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4918173A (es) |
| EP (1) | EP0207424B1 (es) |
| JP (1) | JPS6216496A (es) |
| AT (1) | ATE70836T1 (es) |
| AU (2) | AU594689B2 (es) |
| DE (1) | DE3683090D1 (es) |
| DK (1) | DK312486A (es) |
| ES (4) | ES8707484A1 (es) |
| FR (1) | FR2584406B1 (es) |
| GR (1) | GR861693B (es) |
| PT (1) | PT82898B (es) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1542920A (en) * | 1976-12-22 | 1979-03-28 | Farmaceutici Italia | Antitumour glycosides |
| US4316985A (en) * | 1979-01-16 | 1982-02-23 | Hoffmann-La Roche Inc. | Cyclic compounds |
| FR2454445A1 (fr) * | 1979-10-11 | 1980-11-14 | Erba Farmitalia | Anthracyclines anti-tumeurs |
| US4374979A (en) * | 1981-04-27 | 1983-02-22 | The University Of Kansas Endowment Association | Regiospecific synthesis of anthracyclinone compounds such as daunomycinone |
| AU554416B2 (en) * | 1982-05-24 | 1986-08-21 | Farmitalia Carlo Erba S.P.A. | Anthracycline glycosides |
| FR2560876B1 (fr) * | 1984-03-09 | 1987-01-16 | Hoechst Lab | Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments |
| EP0368866A1 (en) * | 1987-05-15 | 1990-05-23 | Schering Corporation | Aryl substituted naphthalene, benzoxepine, benzazepine, benzocycloheptene derivatives |
-
1985
- 1985-07-02 FR FR8510063A patent/FR2584406B1/fr not_active Expired
-
1986
- 1986-06-24 EP EP86108577A patent/EP0207424B1/en not_active Expired - Lifetime
- 1986-06-24 AT AT86108577T patent/ATE70836T1/de not_active IP Right Cessation
- 1986-06-24 DE DE8686108577T patent/DE3683090D1/de not_active Expired - Fee Related
- 1986-06-25 ES ES556755A patent/ES8707484A1/es not_active Expired
- 1986-06-30 US US06/880,075 patent/US4918173A/en not_active Expired - Fee Related
- 1986-06-30 GR GR861693A patent/GR861693B/el unknown
- 1986-07-01 JP JP61152853A patent/JPS6216496A/ja active Pending
- 1986-07-01 AU AU59440/86A patent/AU594689B2/en not_active Ceased
- 1986-07-01 DK DK312486A patent/DK312486A/da not_active Application Discontinuation
- 1986-07-02 PT PT82898A patent/PT82898B/pt not_active IP Right Cessation
-
1987
- 1987-03-20 ES ES557462A patent/ES8802525A1/es not_active Expired
- 1987-12-16 ES ES557788A patent/ES8801926A1/es not_active Expired
- 1987-12-16 ES ES557789A patent/ES8801927A1/es not_active Expired
-
1989
- 1989-06-15 AU AU36457/89A patent/AU614383B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES8801926A1 (es) | 1988-03-01 |
| ES557462A0 (es) | 1988-07-01 |
| DE3683090D1 (en) | 1992-02-06 |
| AU5944086A (en) | 1987-01-08 |
| ES8801927A1 (es) | 1988-03-01 |
| ATE70836T1 (de) | 1992-01-15 |
| US4918173A (en) | 1990-04-17 |
| DK312486D0 (da) | 1986-07-01 |
| PT82898B (pt) | 1989-01-30 |
| GR861693B (en) | 1986-10-30 |
| PT82898A (en) | 1986-08-01 |
| ES8802525A1 (es) | 1988-07-01 |
| DK312486A (da) | 1987-01-03 |
| EP0207424B1 (en) | 1991-12-27 |
| EP0207424A3 (en) | 1987-10-28 |
| JPS6216496A (ja) | 1987-01-24 |
| ES556755A0 (es) | 1987-08-01 |
| FR2584406B1 (fr) | 1988-09-09 |
| AU3645789A (en) | 1989-11-09 |
| AU594689B2 (en) | 1990-03-15 |
| EP0207424A2 (en) | 1987-01-07 |
| ES8707484A1 (es) | 1987-08-01 |
| FR2584406A1 (fr) | 1987-01-09 |
| AU614383B2 (en) | 1991-08-29 |
| ES557788A0 (es) | 1988-03-01 |
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