ES8801543A1 - Procedimiento para la preparacion de derivados de 1,4-dihidropiridina - Google Patents

Procedimiento para la preparacion de derivados de 1,4-dihidropiridina

Info

Publication number
ES8801543A1
ES8801543A1 ES557423A ES557423A ES8801543A1 ES 8801543 A1 ES8801543 A1 ES 8801543A1 ES 557423 A ES557423 A ES 557423A ES 557423 A ES557423 A ES 557423A ES 8801543 A1 ES8801543 A1 ES 8801543A1
Authority
ES
Spain
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
containing same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557423A
Other languages
English (en)
Other versions
ES557423A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP60269302A external-priority patent/JPH0631223B2/ja
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Publication of ES8801543A1 publication Critical patent/ES8801543A1/es
Publication of ES557423A0 publication Critical patent/ES557423A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 1,4-DIHIDROPIRIDINA, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR A UNA TEMPERATURA COMPRENDIDA ENTRE 80 Y 160 GRADOS Y EN PRESENCIA DE UN DISOLVENTE ORGANICO INERTE, UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R1 REPRESENTA UN GRUPO HETEROCICLICO DE 5 A 6 MIEMBROS; R2 Y R3 REPRESENTAN, AMBOS, ATOMOS DE HALOGENO; R4 REPRESENTA UN GRUPO ALQUILO O ALCOXIALQUILO DE CADENA RECTA O RAMIFICADA; N REPRESENTA 2 O 3; Y X REPRESENTA UN ATOMO DE HALOGENO, UN GRUPO METILOXI, UN GRUPO BENCENO-SULFONILOXI O UN GRUPO TOSILOXI, CON UN COMPUESTO DE FORMULA GENERAL (III), EN LA QUE M REPRESENTA UN METAL DE ALCALI O UN METAL ALCALINOTERREO. DE APLICACION COMO AGENTES VASODILATADORES.
ES557423A 1984-12-14 1987-02-26 Procedimiento para la preparacion de derivados de 1,4-dihidropiridina Expired ES8801543A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP26294284 1984-12-14
JP23335085 1985-10-21
JP23334985 1985-10-21
JP60269302A JPH0631223B2 (ja) 1984-12-14 1985-12-02 １，４−ジヒドロピリジン誘導体およびその製造法

Publications (2)

Publication Number Publication Date
ES8801543A1 true ES8801543A1 (es) 1988-02-16
ES557423A0 ES557423A0 (es) 1988-02-16

Family

ID=27477529

Family Applications (1)

Application Number Title Priority Date Filing Date
ES557423A Expired ES8801543A1 (es) 1984-12-14 1987-02-26 Procedimiento para la preparacion de derivados de 1,4-dihidropiridina

Country Status (4)

Country Link
US (1) US4757071A (es)
EP (1) EP0184841B1 (es)
DE (1) DE3586817T2 (es)
ES (1) ES8801543A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0676405B2 (ja) * 1986-06-13 1994-09-28 日清製粉株式会社 １，４―ジヒドロピリジン誘導体およびそれを含有する医薬組成物
DE3617976A1 (de) * 1986-05-28 1988-01-14 Alter Sa 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
DE3703963A1 (de) * 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen
DE4003541C1 (es) * 1990-02-06 1991-08-08 Alter S.A., Madrid, Es
DE4233347A1 (de) * 1992-10-05 1994-04-07 Bayer Ag Dihydropyridin-alkoxy- und -alkylamino-aroylester
LV12200B (lv) * 1997-07-03 1999-04-20 Gunārs DUBURS Antidiabētisks līdzeklis
CN102464608B (zh) * 2010-11-15 2016-05-11 江苏先声药物研究有限公司 化合物及其作为l-型钙通道阻滞剂或/和乙酰胆碱酯酶抑制剂的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
FR2405937A1 (fr) * 1977-10-14 1979-05-11 Labaz Nouveaux derives de dihydropyridine, leur procede de preparation et leur application
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
US4258042A (en) * 1980-04-11 1981-03-24 Usv Pharmaceutical Corporation Antihypertensive pyridines and compositions
DE3042769A1 (de) * 1980-11-13 1982-06-09 Bayer Ag, 5090 Leverkusen C-3 verknuepfte 1,4-dihydropyridine, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same

Also Published As

Publication number Publication date
DE3586817D1 (de) 1992-12-17
EP0184841A2 (en) 1986-06-18
DE3586817T2 (de) 1993-03-25
EP0184841A3 (en) 1987-09-02
EP0184841B1 (en) 1992-11-11
US4757071A (en) 1988-07-12
ES557423A0 (es) 1988-02-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601