ES8801306A1 - Un metodo de purificar activador de plasminogeno de tejido humano - Google Patents
Un metodo de purificar activador de plasminogeno de tejido humanoInfo
- Publication number
- ES8801306A1 ES8801306A1 ES554450A ES554450A ES8801306A1 ES 8801306 A1 ES8801306 A1 ES 8801306A1 ES 554450 A ES554450 A ES 554450A ES 554450 A ES554450 A ES 554450A ES 8801306 A1 ES8801306 A1 ES 8801306A1
- Authority
- ES
- Spain
- Prior art keywords
- products
- recombinant dna
- dna techniques
- sequence encoding
- cdna sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14111—Inoviridae
- C12N2795/14141—Use of virus, viral particle or viral elements as a vector
- C12N2795/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/70—Vector systems having a special element relevant for transcription from fungi
- C12N2830/702—Vector systems having a special element relevant for transcription from fungi yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Control Of Ac Motors In General (AREA)
- Saccharide Compounds (AREA)
Abstract
METODO PARA PURIFICAR UN ACTIVADOR DE PLASMINOGENO DE TEJIDO HUMANO. COMPRENDE UNA PRIMERA OPERACION DE CROMATOGRAFIA DE AFINIDAD HIDROFOBA UTILIZANDO UN COLORANTE QUE ES CAPAZ DE FIJAR EL ACTIVADOR DE PLASMINOGENO DE TEJIDO HUMANO, PERO QUE NO ES CAPAZ DE FIJARSE A ALGUNAS DE LAS DEMAS PROTEINAS CONTENIDAS EN EL MEDIO DE CELULAS CULTIVADAS QUE PRODUCEN EL ACTIVADOR, A UN PH APROXIMADAMENTE 7,2, PARA FORMAR UN PRIMER PRODUCTO PARCIALMENTE PURIFICADO; UNA SEGUNDA OPERACION EN LA QUE SE REALIZA SOBRE DICHO PRODUCTO PARCIALMENTE PURIFICADO UNA OPERACION DE CROMATOGRAFIA DE AFINIDAD A ANTICUERPOS EN LA QUE DICHO PRODUCTO SE PONE EN CONTACTO CON UN ANTICUERPO FIJADO A UNA COLUMNA; Y UNA TERCERA OPERACION REALIZADA SOBRE EL PRODUCTO PARCIALMENTE PURIFICADO QUE CONSISTE EN UNA CROMATOGRAFIA DE FILTRACION EN GEL, EN LA QUE DICHO PRODUCTO SE PONE EN CONTACTO CON UNA COLUMNA DE AFINIDAD DE GEL CAPAZ DE ELIMINAR CONTAMINANTES SECUNDARIOS DE ALTO PESO MOLECULAR CONTENIDOS EN DICHO PRODUCTO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65677084A | 1984-10-01 | 1984-10-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES554450A0 ES554450A0 (es) | 1988-01-01 |
ES8801306A1 true ES8801306A1 (es) | 1988-01-01 |
Family
ID=24634490
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES547416A Expired ES8702945A1 (es) | 1984-10-01 | 1985-09-30 | Un metodo de producir activador de plasminogeno de tejido uterino humano |
ES554450A Expired ES8801306A1 (es) | 1984-10-01 | 1986-04-28 | Un metodo de purificar activador de plasminogeno de tejido humano |
ES554449A Expired ES8706726A1 (es) | 1984-10-01 | 1986-04-28 | Un metodo de purificar activador de plasminogeno de tejido uterino |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES547416A Expired ES8702945A1 (es) | 1984-10-01 | 1985-09-30 | Un metodo de producir activador de plasminogeno de tejido uterino humano |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES554449A Expired ES8706726A1 (es) | 1984-10-01 | 1986-04-28 | Un metodo de purificar activador de plasminogeno de tejido uterino |
Country Status (14)
Country | Link |
---|---|
US (1) | US5344773A (es) |
EP (1) | EP0178105B1 (es) |
JP (1) | JPS61149094A (es) |
AT (1) | ATE151111T1 (es) |
AU (1) | AU599576B2 (es) |
DE (1) | DE3588149T2 (es) |
DK (1) | DK175327B1 (es) |
ES (3) | ES8702945A1 (es) |
FI (1) | FI89723C (es) |
IE (1) | IE81135B1 (es) |
NO (1) | NO175158C (es) |
NZ (1) | NZ213647A (es) |
PT (1) | PT81231B (es) |
ZA (1) | ZA857574B (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3479520D1 (en) * | 1983-11-21 | 1989-09-28 | Ciba Geigy Ag | Synthesis of tissue plasminogen activator(tpa) by yeast |
US5073494A (en) * | 1985-04-22 | 1991-12-17 | Genentech, Inc. | Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277 |
GB8528321D0 (en) * | 1985-11-18 | 1985-12-24 | Ciba Geigy Ag | Modified fibrinolytic agents |
JP2581668B2 (ja) * | 1985-11-27 | 1997-02-12 | 三井東圧化学株式会社 | ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいdna配列とそれを含むベクタ−及び細胞 |
ZA869626B (en) * | 1985-12-23 | 1987-10-28 | Chiron Corp | Peptide plasminogen activators |
WO1987004722A1 (en) * | 1986-01-31 | 1987-08-13 | Genetics Institute, Inc. | Novel thrombolytic proteins |
US5837518A (en) * | 1986-01-31 | 1998-11-17 | Genetics Institute, Inc. | Thrombolytic proteins |
US5258298A (en) * | 1986-01-31 | 1993-11-02 | Genetics Institute, Inc. | Deletion and glycosylation mutant of human tissue plasminogen activator |
US5589361A (en) * | 1986-03-18 | 1996-12-31 | Genentech, Inc. | Human tissue-type plasminogen activator variant |
IE81073B1 (en) * | 1986-03-18 | 2000-01-12 | Genentech Inc | Modified human tissue-type plasminogen activator and its preparation |
DE122007000007I2 (de) | 1986-04-09 | 2010-12-30 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
US5047241A (en) * | 1986-07-11 | 1991-09-10 | American Home Products Corporation | Tris-Kringle plasminogen activator with novel K2 insert |
WO1988000615A1 (en) * | 1986-07-16 | 1988-01-28 | Celltech Limited | Process for purifying a plasminogen activator |
US5242819A (en) * | 1986-12-05 | 1993-09-07 | Ciba-Geigy Corporation | DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase |
US5580559A (en) * | 1986-12-05 | 1996-12-03 | Ciba-Geigy Corporation | Hybrid plasminogen activator |
EP0276846A3 (en) * | 1987-01-29 | 1989-07-26 | Zymogenetics, Inc. | Colony-stimulating factor derivatives |
US5376547A (en) * | 1987-01-30 | 1994-12-27 | American Home Products Corporation | Des-epidermal growth factor plasminogen activators |
JPH084501B2 (ja) * | 1987-03-20 | 1996-01-24 | エーザイ株式会社 | 糖鎖に関する変異tPA |
NO882226L (no) * | 1987-05-22 | 1988-11-23 | Zymogenetics Inc | Fibrinolytiske proteiner. |
AU1668988A (en) * | 1987-06-03 | 1988-12-08 | Smithkline Beckman Corporation | Purification of tpa |
US6682733B1 (en) * | 1987-06-18 | 2004-01-27 | Roche Diagnostics, Gmbh | Fibrinolytic enzymes |
DE3726019A1 (de) * | 1987-08-05 | 1989-02-16 | Boehringer Mannheim Gmbh | Verfahren zur abtrennung und reinigung von t-pa |
US5037752A (en) * | 1987-10-09 | 1991-08-06 | Monsanto Company | Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277 |
US5100666A (en) * | 1987-10-09 | 1992-03-31 | Monsanto Company | Modified tissue plasminogen activator K2K2SP |
US4963357A (en) * | 1987-10-09 | 1990-10-16 | Monsanto Company | Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor |
US5244676A (en) * | 1987-10-09 | 1993-09-14 | Monsanto Company | Modified tissue plasminogen activator with modified glycosylation site |
US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
US5665583A (en) * | 1988-08-12 | 1997-09-09 | Arch Dev Corp | Methods and materials relating to IMPDH and GMP production |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
US5070021A (en) * | 1989-01-10 | 1991-12-03 | Monsanto Company | Method of modifying oligosaccharide structure of tissue plasminogen activator |
US5268273A (en) * | 1990-12-14 | 1993-12-07 | Phillips Petroleum Company | Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same |
ATE246000T1 (de) * | 1992-06-03 | 2003-08-15 | Genentech Inc | Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung |
US7299805B2 (en) | 2002-06-07 | 2007-11-27 | Marctec, Llc | Scaffold and method for implanting cells |
US10160813B2 (en) | 2013-01-22 | 2018-12-25 | University Of Tennessee Research Foundation | Tissue plasminogen activator antibodies and methods of use |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4370417A (en) * | 1980-04-03 | 1983-01-25 | Abbott Laboratories | Recombinant deoxyribonucleic acid which codes for plasminogen activator |
US4419446A (en) * | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
HU200615B (en) * | 1982-05-05 | 1990-07-28 | Genentech Inc | Methods of preparing tissue plasiminogen activator derivative composition |
AR241654A1 (es) * | 1982-05-05 | 1992-10-30 | Genentech Inc | Procedimiento para producir activador de plasminogeno de tejido humano. |
EP0125254A1 (en) * | 1982-10-28 | 1984-11-21 | Beecham Group Plc | Enzyme derivatives and their use in the treatment of thrombosis |
AU554862B2 (en) * | 1982-12-14 | 1986-09-04 | Implico B.V. | Plasminogen activator isolated by affinity chromatography |
AU572108B2 (en) * | 1983-01-19 | 1988-05-05 | Genentech Inc. | Human tpa production using vectors coding for dhfr protein |
DE3479520D1 (en) * | 1983-11-21 | 1989-09-28 | Ciba Geigy Ag | Synthesis of tissue plasminogen activator(tpa) by yeast |
US4753879A (en) * | 1984-08-27 | 1988-06-28 | Biogen N.V. | Modified tissue plasminogen activators |
GB8528321D0 (en) * | 1985-11-18 | 1985-12-24 | Ciba Geigy Ag | Modified fibrinolytic agents |
ZA869626B (en) * | 1985-12-23 | 1987-10-28 | Chiron Corp | Peptide plasminogen activators |
IE81073B1 (en) * | 1986-03-18 | 2000-01-12 | Genentech Inc | Modified human tissue-type plasminogen activator and its preparation |
-
1985
- 1985-09-30 DK DK198504415A patent/DK175327B1/da not_active IP Right Cessation
- 1985-09-30 IE IE239485A patent/IE81135B1/en not_active IP Right Cessation
- 1985-09-30 NO NO853851A patent/NO175158C/no not_active IP Right Cessation
- 1985-09-30 ES ES547416A patent/ES8702945A1/es not_active Expired
- 1985-09-30 AT AT85306957T patent/ATE151111T1/de not_active IP Right Cessation
- 1985-09-30 EP EP85306957A patent/EP0178105B1/en not_active Expired - Lifetime
- 1985-09-30 NZ NZ213647A patent/NZ213647A/xx unknown
- 1985-09-30 FI FI853761A patent/FI89723C/fi not_active IP Right Cessation
- 1985-09-30 DE DE3588149T patent/DE3588149T2/de not_active Expired - Lifetime
- 1985-10-01 ZA ZA857574A patent/ZA857574B/xx unknown
- 1985-10-01 PT PT81231A patent/PT81231B/pt unknown
- 1985-10-01 US US06/782,686 patent/US5344773A/en not_active Expired - Lifetime
- 1985-10-01 JP JP60216313A patent/JPS61149094A/ja active Pending
- 1985-10-01 AU AU48148/85A patent/AU599576B2/en not_active Expired
-
1986
- 1986-04-28 ES ES554450A patent/ES8801306A1/es not_active Expired
- 1986-04-28 ES ES554449A patent/ES8706726A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE3588149T2 (de) | 1997-10-09 |
EP0178105A2 (en) | 1986-04-16 |
ES554450A0 (es) | 1988-01-01 |
IE852394L (en) | 1986-04-01 |
DK441585D0 (da) | 1985-09-30 |
NO175158B (no) | 1994-05-30 |
FI89723B (fi) | 1993-07-30 |
AU4814885A (en) | 1986-04-10 |
ES8702945A1 (es) | 1987-01-16 |
IE81135B1 (en) | 2000-03-22 |
DK441585A (da) | 1986-04-02 |
NZ213647A (en) | 1989-05-29 |
FI853761L (fi) | 1986-04-02 |
NO175158C (no) | 1994-09-07 |
PT81231B (pt) | 1987-10-20 |
EP0178105A3 (en) | 1988-11-17 |
ES8706726A1 (es) | 1987-07-01 |
DK175327B1 (da) | 2004-08-23 |
DE3588149D1 (de) | 1997-05-07 |
NO853851L (no) | 1986-04-02 |
FI853761A0 (fi) | 1985-09-30 |
JPS61149094A (ja) | 1986-07-07 |
ES547416A0 (es) | 1987-01-16 |
ATE151111T1 (de) | 1997-04-15 |
US5344773A (en) | 1994-09-06 |
FI89723C (fi) | 1993-11-10 |
ES554449A0 (es) | 1987-07-01 |
EP0178105B1 (en) | 1997-04-02 |
AU599576B2 (en) | 1990-07-26 |
ZA857574B (en) | 1986-06-25 |
PT81231A (en) | 1985-11-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20071117 |