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Laboratorios Salvat SA
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Laboratorios Salvat SA
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Priority to ES556940ApriorityCriticalpatent/ES8708129A1/en
Publication of ES8708129A1publicationCriticalpatent/ES8708129A1/en
Publication of ES556940A0publicationCriticalpatent/ES556940A0/en
The asymmetric methyl ethyl diester of 2,6-dimethyl 4-(3'-nitro phenyl) 1,4-dihydropyridine 3,5-dicarboxylic acid of formula (I), for use as a coronary vasodilator is made by reacting the methyl ester of 3'-nitro benzylidene acetoacetic acid of formula (II) with ethyl acetate and core ammonia in ethanol or isopropanol under reflux.
DERIVATIVES OF 2-AMINO-N - {{((4- (AMINO CARBONYL) -PIRIMIDIN-2-IL-AMINO) -ALKYL} -PIRIMIDI N-4-CARBOXAMIDE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS.