ES8707862A1 - Procedimiento para la obtencion de un anticuerpo monoclonal contra la hormona estimuladroa de foliculos - Google Patents

Procedimiento para la obtencion de un anticuerpo monoclonal contra la hormona estimuladroa de foliculos

Info

Publication number
ES8707862A1
ES8707862A1 ES552703A ES552703A ES8707862A1 ES 8707862 A1 ES8707862 A1 ES 8707862A1 ES 552703 A ES552703 A ES 552703A ES 552703 A ES552703 A ES 552703A ES 8707862 A1 ES8707862 A1 ES 8707862A1
Authority
ES
Spain
Prior art keywords
follicle
monoclonal antibody
stimulating hormone
determination
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552703A
Other languages
English (en)
Other versions
ES552703A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6264313&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8707862(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES8707862A1 publication Critical patent/ES8707862A1/es
Publication of ES552703A0 publication Critical patent/ES552703A0/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PROCEDIMIENTO DE SINTESIS DE UN ANTICUERPO MONOCLONAL CONTRA LA HORMONA ESTIMULADORA DE FOLICULOS (FSH). COMPRENDE: A) INMUNIZAR CON FSH ANIMALES APROPIADOS; B) OBTENER LINFOCITOS-B A PARTIR DEL BAZO DE LOS ANIMALES INMUNIZADOS; C) FUSIONAR LOS LINFOCITOS-B CON CELULAS DE MIELOMA; D) CLONAR LOS HIBRIDOMAS FORMADOS EN LA ETAPA C); E) SELECCIONAR LOS CLONES QUE PRODUCEN ANTICUERPOS ESPECIFICOS CONTRA FSH, DEL TIPO QUE REACCIONAN DE MODO CRUZADO EN MENOS DEL 13% CON OTRAS HORMONAS GLICOPROTEICAS, Y EN MENOS DEL 1% CON LA HORMONA LUTENEIZANTE (LH), LA HORMONA ESTIMULADORA DE TIZETROPINA (TSH) Y LA CORIOGONADOTROPINA HUMANA (HCG); Y F) OBTENER LOS ANTICUERPOS MONOCLONALES FORMADOS POR LOS CLONES SELECCIONADOS EN E). SE UTILIZAN EN LA EVALUACION DEL ESTADO ENDOCRINOLOGICO DEL HIPOTALAMO, LA HIPOFISIS Y LAS GONADAS.
ES552703A 1985-03-06 1986-03-06 Procedimiento para la obtencion de un anticuerpo monoclonal contra la hormona estimuladroa de foliculos Expired ES8707862A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853507849 DE3507849A1 (de) 1985-03-06 1985-03-06 Verfahren und reagenz zur bestimmung des follikel stimulierenden hormons sowie hierzu geeignete monoklonale antikoerper

Publications (2)

Publication Number Publication Date
ES8707862A1 true ES8707862A1 (es) 1987-09-16
ES552703A0 ES552703A0 (es) 1987-09-16

Family

ID=6264313

Family Applications (2)

Application Number Title Priority Date Filing Date
ES552705A Expired ES8802090A1 (es) 1985-03-06 1986-03-06 Procedimiento inmunologico para la determinacion de la hormona estimuladora de foliculos
ES552703A Expired ES8707862A1 (es) 1985-03-06 1986-03-06 Procedimiento para la obtencion de un anticuerpo monoclonal contra la hormona estimuladroa de foliculos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES552705A Expired ES8802090A1 (es) 1985-03-06 1986-03-06 Procedimiento inmunologico para la determinacion de la hormona estimuladora de foliculos

Country Status (11)

Country Link
US (1) US4762783A (es)
EP (1) EP0193880B1 (es)
JP (1) JPS61218600A (es)
KR (1) KR860007373A (es)
AT (1) ATE143146T1 (es)
AU (1) AU556178B1 (es)
CA (1) CA1273305A (es)
DE (2) DE3507849A1 (es)
ES (2) ES8802090A1 (es)
FI (1) FI91976C (es)
ZA (1) ZA861551B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1273506B (it) † 1995-04-06 1997-07-08 Scient Marketing Service S R L Test diagnostico per il rilevamento rapido e sicuro di un marcatore clinico per la diagnosi di menopausa nella donna
EP1143250A3 (en) * 2000-04-03 2004-11-17 Inverness Medical Switzerland GmbH Test methods and devices for analyte isoforms
EP1143249B1 (en) * 2000-04-03 2014-01-15 Alere Switzerland GmbH Test methods and devices for analyte isoforms
JP2001349892A (ja) * 2000-04-03 2001-12-21 Unilever Nv 検査方法及びデバイス
US20070281883A1 (en) * 2006-06-05 2007-12-06 Hanna Rosenfeld Development of follicle stimulating hormone agonists and antagonists in fish

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3114362C2 (de) * 1980-04-11 1983-08-18 Toshiyuki Prof. Nara Hamaoka Verfahren zur Herstellung eines Antikörpers bzw. Antiserums, Verwendung dieses Verfahrens zur Gewinnung von Säugetierzellen, welche fähig sind, einen solchen Antikörper zu erzeugen und Verwendung des so hergestellten Antikörpers bzw. Antiserums zur Immunoprüfung
GB2111201A (en) * 1981-12-10 1983-06-29 Celltech Ltd Immunoassay of human luteinising hormone

Also Published As

Publication number Publication date
FI91976C (fi) 1994-09-12
ZA861551B (en) 1986-11-26
JPH0471519B2 (es) 1992-11-13
ATE143146T1 (de) 1996-10-15
EP0193880A3 (de) 1988-11-17
ES552705A0 (es) 1988-04-01
EP0193880A2 (de) 1986-09-10
ES8802090A1 (es) 1988-04-01
AU556178B1 (en) 1986-10-23
ES552703A0 (es) 1987-09-16
DE3650570D1 (de) 1996-10-24
US4762783A (en) 1988-08-09
FI860937A0 (fi) 1986-03-05
DE3507849A1 (de) 1986-09-11
JPS61218600A (ja) 1986-09-29
CA1273305A (en) 1990-08-28
FI91976B (fi) 1994-05-31
FI860937A (fi) 1986-09-07
EP0193880B1 (de) 1996-09-18
KR860007373A (ko) 1986-10-10

Similar Documents

Publication Publication Date Title
ES8206856A1 (es) Mejoras en un metodo y su correspondiente equipo de ensayo para determinar antigenos por medio de una reaccion inmuno- quimica
MY110207A (en) Stabilised antibodies
ATA399781A (de) Vorrichtung zur verhinderung der verdrehung eines flexiblen schlauchgurtes in einem schlauchgurtfoerderer
EP0176355A3 (en) Antigen-independent immunoassay system
EP0432249A4 (en) Monoclonal antibodies against leukocyte adhesion receptor -g(b)-chain, methods of producing these antibodies and use therefore
PT85490A (en) Process for the preparation of specific monoclonal antibodies of apolipoprotein-b and essay processes for the determination o the above mentioned apolipoprotein
EP0220063A3 (en) Anti-human interleukin 1 antibody, method for the production thereof and use of the same
ES8707862A1 (es) Procedimiento para la obtencion de un anticuerpo monoclonal contra la hormona estimuladroa de foliculos
EP0182546A3 (en) Immunoassays
ES8802263A1 (es) Procedimiento inmunologico para la determinacion de la hormona luteinizante
EP0287397A3 (en) Monoclonal antibody specific to human pancreatic phospholipase a2
JPS57208458A (en) Labeled antibody for immunochemical measurement
DE3569161D1 (en) Process for assaying atl virus antibody and reagent therefore
KR900002074A (ko) 감마 아트리알 나트륨 이뇨성 폴리펩티드를 인식하는 단일 클론 항체
ES8401261A1 (es) Soportes de materia plastica revestidos de un segundo anticuerpo.
EP0328248A3 (en) Monoclonal antibodies against a follicle-stimulating hormone
AU560262B2 (en) Antibodies derived from hybrid line from (myeloma + antibody producing cell)
EP0089771A3 (en) Atcc hb8116 and its monoclonal anti-h-y antibody, hyclonalan
EP0255367A3 (en) Cancer cell specific monoclonal antibodies and corresponding hybridomas, and their preparation and use
GR3014977T3 (en) Monoclonal antibody against endothelin, hybridoma capable of producing the same and radioimmunoassay for endothelin by using the same.
EP0344320A4 (en) MONOCLONAL HUMAN ANTIBODIES AGAINST CANDIDA.
EP0260715A3 (en) Monoclonal antibody
UA8618A1 (uk) Спосіб коhтролю ступіhі очистки тісі4(нижній індекс)
JPS5386013A (en) Quantitative analysis of pituitary hormone

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100315