ES8707242A1 - Un procedimiento para la preparacion de nuevos derivados de milbemicina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de milbemicina.

Info

Publication number
ES8707242A1
ES8707242A1 ES555569A ES555569A ES8707242A1 ES 8707242 A1 ES8707242 A1 ES 8707242A1 ES 555569 A ES555569 A ES 555569A ES 555569 A ES555569 A ES 555569A ES 8707242 A1 ES8707242 A1 ES 8707242A1
Authority
ES
Spain
Prior art keywords
derivatives
halomilbemycin
preparation
compositions containing
oxime group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555569A
Other languages
English (en)
Other versions
ES555569A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES8707242A1 publication Critical patent/ES8707242A1/es
Publication of ES555569A0 publication Critical patent/ES555569A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE MILBEMICINA. CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON TRIFLUORO DE DIMETILAMINOAZUFRE O TRICLORURO DE FOSFORO, EN BENCENO O DIMETILFORMAMIDA, ENTRE C70JC Y B80JC Y DURANTE 15 MINUTOS A 1 DIA, PARA CONVERTIR UN GRUPO HIDROXI EN LA POSICION 13 EN HAL Y OBTENER UN COMPUESTO DE FORMULA (I) O SALES ESTERES DEL MISMO. SIENDO: R1, ETILO O SEC-BUTILO; X, HAL; E Y Y Z, OXIGENO. SE UTILIZAN COMO ANTIHELMINTICOS Y ACARICIDAS.
ES555569A 1985-05-31 1986-05-30 Un procedimiento para la preparacion de nuevos derivados de milbemicina. Expired ES8707242A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11862985 1985-05-31

Publications (2)

Publication Number Publication Date
ES8707242A1 true ES8707242A1 (es) 1987-07-16
ES555569A0 ES555569A0 (es) 1987-07-16

Family

ID=14741259

Family Applications (1)

Application Number Title Priority Date Filing Date
ES555569A Expired ES8707242A1 (es) 1985-05-31 1986-05-30 Un procedimiento para la preparacion de nuevos derivados de milbemicina.

Country Status (12)

Country Link
US (1) US4945105A (es)
EP (1) EP0203832B1 (es)
JP (1) JPS6289685A (es)
CN (1) CN1018456B (es)
AT (1) ATE52781T1 (es)
BR (1) BR8602522A (es)
DE (1) DE3671228D1 (es)
EG (1) EG18548A (es)
ES (1) ES8707242A1 (es)
OA (1) OA08336A (es)
SU (1) SU1537140A3 (es)
ZA (1) ZA864042B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3707859A1 (de) * 1986-03-12 1987-10-08 Glaxo Group Ltd Makrolidverbindung
JP2577734B2 (ja) * 1986-03-12 1997-02-05 アメリカン・サイアナミツド・カンパニー マクロライド抗生物質
RU2024527C1 (ru) * 1986-03-25 1994-12-15 Санкио Компани Лимитед Способ получения макролидных соединений
US4897416A (en) * 1987-02-18 1990-01-30 Ciba-Geigy Corporation Insecticides and parasiticides
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
US4918097A (en) * 1988-03-11 1990-04-17 Ciba-Geigy Corporation Insecticides and parasiticides
NZ228866A (en) * 1988-05-02 1991-10-25 Merck & Co Inc Fluoro-substituted milbemycins and avermectins for combatting parasites and insects
US5428034A (en) * 1988-09-02 1995-06-27 Sankyo Co., Ltd. Milbemycin derivatives, their preparation and their use
US5030650A (en) * 1989-09-11 1991-07-09 American Cyanamid Company 13-halo-23-imino derivatives of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents
EP0443733B1 (en) * 1990-02-08 1993-07-21 Merck & Co. Inc. Method for the treatment of fleas
JP2622197B2 (ja) * 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
KR0171426B1 (ko) * 1991-12-18 1999-02-01 가와무라 요시부미 13-(치환 티오) 아세톡시밀베마이신 유도체, 그의 제조방법 및 농화학적 용도
US5229416A (en) * 1992-04-29 1993-07-20 Merck & Co., Inc. Avermectin difluoro derivatives
US5411946A (en) * 1993-02-24 1995-05-02 Merck & Co., Inc. Avermectin derivatives
US5614470A (en) * 1994-04-01 1997-03-25 Sankyo Company, Limited 13-substituted milbemycin derivatives, their preparation and their use
PT765879E (pt) * 1995-09-29 2001-05-31 Sankyo Co Derivados 13-substituidos de milbemicina-5-oxima sua preparacao e utilizacao contra insectos e outras pragas
CN1247607C (zh) 2000-04-27 2006-03-29 三共生命科技株式会社 13－取代的米尔螨素衍生物,它们的制备方法及其杀昆虫和其它有害动物的用途
EP1849363A1 (en) * 2006-03-09 2007-10-31 Cheminova A/S Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
EP2886640A1 (en) 2013-12-18 2015-06-24 Riga Technical University Process for isolation of milbemycins A3 and A4
CN104327094B (zh) * 2014-10-30 2016-08-17 湖北宏中药业有限公司 一种米尔贝肟的分离纯化方法
CN105254644B (zh) * 2015-11-04 2017-07-18 湖北宏中药业股份有限公司 一种米尔贝肟的制备方法
CN108640927B (zh) * 2018-04-27 2021-05-07 丽珠集团福州福兴医药有限公司 一种米尔贝肟的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US32034A (en) * 1861-04-09 Langdon sawyer
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US4093629A (en) 1977-04-11 1978-06-06 Merck & Co., Inc. Derivatives of antibiotic substance milbemycin and processes therefor
US4134973A (en) * 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4173571A (en) 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
IL56149A (en) * 1977-12-19 1989-09-28 Merck & Co Inc 13-halo and 13-deoxy derivatives of c-076 compounds,their preparation and method for the treatment of parasitic infections in animals therewith
JPS5632481A (en) * 1979-08-23 1981-04-01 Sankyo Co Ltd Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
US4423209A (en) 1982-02-26 1983-12-27 Merck & Co., Inc. Processes for the interconversion of avermectin compounds
JPS59108785A (ja) 1982-11-25 1984-06-23 Sankyo Co Ltd ミルベマイシン類の５−オキシム誘導体

Also Published As

Publication number Publication date
BR8602522A (pt) 1987-01-27
DE3671228D1 (de) 1990-06-21
CN86104380A (zh) 1987-02-11
ES555569A0 (es) 1987-07-16
EP0203832B1 (en) 1990-05-16
EP0203832A1 (en) 1986-12-03
JPH0586794B2 (es) 1993-12-14
US4945105A (en) 1990-07-31
CN1018456B (zh) 1992-09-30
ZA864042B (en) 1987-01-28
ATE52781T1 (de) 1990-06-15
JPS6289685A (ja) 1987-04-24
OA08336A (fr) 1988-02-29
SU1537140A3 (ru) 1990-01-15
EG18548A (en) 1993-06-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601