ES8705881A1 - New 3-piperidinyl -1,2-benz-isothiazole and -isoxazole derivs. - Google Patents

New 3-piperidinyl -1,2-benz-isothiazole and -isoxazole derivs.

Info

Publication number
ES8705881A1
ES8705881A1 ES553419A ES553419A ES8705881A1 ES 8705881 A1 ES8705881 A1 ES 8705881A1 ES 553419 A ES553419 A ES 553419A ES 553419 A ES553419 A ES 553419A ES 8705881 A1 ES8705881 A1 ES 8705881A1
Authority
ES
Spain
Prior art keywords
halo
alkyl
piperidinyl
new
derivs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553419A
Other languages
Spanish (es)
Other versions
ES553419A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24880589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8705881(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES553419A0 publication Critical patent/ES553419A0/en
Publication of ES8705881A1 publication Critical patent/ES8705881A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Piperidine derivs. of formula (I) and their pharmaceutically acceptable acid addn. salts are new. R = H or 1-6C alkyl; R1 and R2 = H, halo, OH, 1-6C alkoxy or 1-6C alkyl; X = O or S; Alk = 1-4C alkanediyl; Q = a gp. of formula (a) or (b); Y1 and Y2 = O or S; R3 = H, halo, 1-6C alkyl, 1-6C alkoxy, CF3, NO2, CN, OH, 2-11C alkenoyloxy, NH2, mono- or di(1-6C alkyl)amino, 2-11C alkanoylamino, benzyloxy or azido; R4 = H or halo, R5 = H or 1-6C alkyl; Z = S, CH2 or C(R6) = C(R7); R6 and R7 = H or 1-6C alkyl; A = CH2CH2, CH2CH2CH2 or C(R8)=C(R9); R8 and R9 = H, halo, NH2 or 1-6C alkyl. More specifically, R = H; R1 = H or halo; R2 = H, halo, OH or 1-6C alkoxy; R3 = H, halo or Me; Y1 = O; Z-A = SCH2CH2, S(CH2)3; S-CR8=CR9, CH=CH-CR8=CR9 or (CH2)4; R8 and R9 = H or Me. 2 Cpds. (I) including 3-(2-(4-(6-fluoro -1,2-benzioxazol-3-yl)-1 piperidinyl)ethyl)-6,7,8,9 -tetrahydro-2-methyl-4H -pyrido(1,2-a) pyrimidin-4-one (Ia) are specifically claimed.
ES553419A 1985-03-27 1986-03-25 New 3-piperidinyl -1,2-benz-isothiazole and -isoxazole derivs. Expired ES8705881A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71706785A 1985-03-27 1985-03-27

Publications (2)

Publication Number Publication Date
ES553419A0 ES553419A0 (en) 1987-05-16
ES8705881A1 true ES8705881A1 (en) 1987-05-16

Family

ID=24880589

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553419A Expired ES8705881A1 (en) 1985-03-27 1986-03-25 New 3-piperidinyl -1,2-benz-isothiazole and -isoxazole derivs.

Country Status (13)

Country Link
KR (1) KR910000165B1 (en)
AT (1) ATE79379T1 (en)
DE (1) DE3686341T2 (en)
ES (1) ES8705881A1 (en)
FI (1) FI81800C (en)
GR (1) GR860800B (en)
HU (1) HU195793B (en)
IL (1) IL78250A (en)
NO (2) NO162765C (en)
NZ (1) NZ215462A (en)
PH (1) PH24016A (en)
PT (1) PT82254B (en)
ZA (1) ZA862279B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2050069A1 (en) * 1992-07-10 1994-05-01 Vita Invest Sa Prepn of anti-psychotic pyrimidinone - which is 3-(2-(4-(6-fluoro- 1,2-benzisoxazol 3-yl)piperidino) ethyl)-2-methyl- 6,7,8,9-tetra- hydro-4H-pyrido (1,2-a) pyrimidin-4-one
ES2085234A1 (en) * 1994-02-24 1996-05-16 Vita Invest Sa Agent acting on the central nervous system, process for its preparation and pharmaceutical compositions containing it
WO2006046082A1 (en) * 2004-10-25 2006-05-04 Richter Gedeon Vegyészeti Gyár Rt. A process for the preparation of risperidone

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2050069A1 (en) * 1992-07-10 1994-05-01 Vita Invest Sa Prepn of anti-psychotic pyrimidinone - which is 3-(2-(4-(6-fluoro- 1,2-benzisoxazol 3-yl)piperidino) ethyl)-2-methyl- 6,7,8,9-tetra- hydro-4H-pyrido (1,2-a) pyrimidin-4-one
ES2085234A1 (en) * 1994-02-24 1996-05-16 Vita Invest Sa Agent acting on the central nervous system, process for its preparation and pharmaceutical compositions containing it
WO2006046082A1 (en) * 2004-10-25 2006-05-04 Richter Gedeon Vegyészeti Gyár Rt. A process for the preparation of risperidone

Also Published As

Publication number Publication date
FI861328A0 (en) 1986-03-26
IL78250A (en) 1991-05-12
PH24016A (en) 1990-02-09
HU195793B (en) 1988-07-28
NO162765B (en) 1989-11-06
HUT42461A (en) 1987-07-28
KR910000165B1 (en) 1991-01-21
FI861328A (en) 1986-09-28
ES553419A0 (en) 1987-05-16
KR860007247A (en) 1986-10-10
DE3686341D1 (en) 1992-09-17
NO1994021I1 (en) 1994-11-03
PT82254B (en) 1988-04-21
PT82254A (en) 1986-04-01
DE3686341T2 (en) 1993-01-14
ZA862279B (en) 1987-11-25
FI81800C (en) 1990-12-10
GR860800B (en) 1986-07-21
NZ215462A (en) 1988-09-29
IL78250A0 (en) 1986-07-31
FI81800B (en) 1990-08-31
NO162765C (en) 1990-02-14
ATE79379T1 (en) 1992-08-15
NO861230L (en) 1986-09-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070331