FI861328A - NYA 1,2-BENZIOXAZOLE-3-YL-OCH 1,2-BENZISOTIAZOLE-3-YL DERIVATIVES. - Google Patents
NYA 1,2-BENZIOXAZOLE-3-YL-OCH 1,2-BENZISOTIAZOLE-3-YL DERIVATIVES. Download PDFInfo
- Publication number
- FI861328A FI861328A FI861328A FI861328A FI861328A FI 861328 A FI861328 A FI 861328A FI 861328 A FI861328 A FI 861328A FI 861328 A FI861328 A FI 861328A FI 861328 A FI861328 A FI 861328A
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- hydrogen
- halogen
- amino
- groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention relates to a process for preparing novel 1, 2-benzisoxazol-3-yl- and 1,2-benzisotiaxol -3-yl derivatives of the formula (I), in which R is hydrogen or C1-6-alkyl, each of the groups R1 and R2 is independently hydrogen, halogen or hydroxyl or C1-6-alkyl; x is O or S; Alk is C1-4-alkanediyl; Q is a group of the formula (a), in which Y1 and Y2 are each independently O or S; R3 is hydrogen, halogen or C1-6-alkyl, C1-6-alkoxy, trifluoromethyl, nitro, cyano, hydroxyl, (C1-10- alkylcarbonyl)oxy, amino, mono- or di(C1-6-alkyl) amino, (C1-10-alkylcarbonyl)amino, phenylmethoxy or azide; R4 is hydrogen or halogen or a group of the formula (b) in which R5 is hydrogen of C1-6-alkyl; Z is -S-, -CH2-or CR6- CR7-, where each of the groups R6 and R7 is independently hydrogen or C1-6-alkyl; and A is a bivalent group -CH2-CH2-CH2- or -CR8-CR9- and each of the groups R8 and R9 is independently hydrogen, halogen, amino or alkyl; and their pharmaceutically acceptable acid addition salts. The compounds possess excellent antipsychotic properties and can be used when treating various disorders in which the release of scrotonin is of predominant importance. <IMAGE>
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI893001A FI893001A (en) | 1985-03-27 | 1989-06-19 | FOR EXAMINATION OF FRAMSTAELLNING AV NYA, THERAPEUTIC ANVAENDBARA 1,2-BENZISOXAZOLE-3-YL-OCH 1,2-BENZISOTIAZOLE-3-YLDERIVAT. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71706785A | 1985-03-27 | 1985-03-27 | |
US71706785 | 1985-03-27 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI861328A0 FI861328A0 (en) | 1986-03-26 |
FI861328A true FI861328A (en) | 1986-09-28 |
FI81800B FI81800B (en) | 1990-08-31 |
FI81800C FI81800C (en) | 1990-12-10 |
Family
ID=24880589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI861328A FI81800C (en) | 1985-03-27 | 1986-03-26 | Process for the preparation of novel therapeutically useful 1,2-benzis oxazol-3-yl-1-piperidinylalkylpyridopyrimidinone and thiazolopyrimidine derivatives |
Country Status (13)
Country | Link |
---|---|
KR (1) | KR910000165B1 (en) |
AT (1) | ATE79379T1 (en) |
DE (1) | DE3686341T2 (en) |
ES (1) | ES8705881A1 (en) |
FI (1) | FI81800C (en) |
GR (1) | GR860800B (en) |
HU (1) | HU195793B (en) |
IL (1) | IL78250A (en) |
NO (2) | NO162765C (en) |
NZ (1) | NZ215462A (en) |
PH (1) | PH24016A (en) |
PT (1) | PT82254B (en) |
ZA (1) | ZA862279B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2050069B1 (en) * | 1992-07-10 | 1994-12-16 | Vita Invest Sa | PROCEDURE FOR OBTAINING 3- (2- (4- (6-FLUORO-1,2-BENZISOXAZOL-3-IL) PIPERIDINO) ETIL) -2-METHYL-6,7,8,9-TETRAHIDRO-4H-PIRIDO (1,2-A) PIRIMIDIN-4-ONA. |
ES2085234B1 (en) * | 1994-02-24 | 1997-01-16 | Vita Invest Sa | ACTIVE AGENT ON THE CENTRAL NERVOUS SYSTEM, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT. |
HUP0402163A2 (en) * | 2004-10-25 | 2006-05-29 | Richter Gedeon Vegyeszet | Process for the preparation of risperidone |
-
1986
- 1986-02-10 KR KR1019860000902A patent/KR910000165B1/en not_active IP Right Cessation
- 1986-03-12 NZ NZ215462A patent/NZ215462A/en unknown
- 1986-03-13 AT AT86200400T patent/ATE79379T1/en active
- 1986-03-13 DE DE8686200400T patent/DE3686341T2/en not_active Expired - Lifetime
- 1986-03-24 PT PT82254A patent/PT82254B/en unknown
- 1986-03-25 ES ES553419A patent/ES8705881A1/en not_active Expired
- 1986-03-25 IL IL78250A patent/IL78250A/en unknown
- 1986-03-26 ZA ZA862279A patent/ZA862279B/en unknown
- 1986-03-26 FI FI861328A patent/FI81800C/en not_active IP Right Cessation
- 1986-03-26 HU HU861278A patent/HU195793B/en unknown
- 1986-03-26 NO NO861230A patent/NO162765C/en unknown
- 1986-03-26 GR GR860800A patent/GR860800B/en unknown
- 1986-03-26 PH PH33589A patent/PH24016A/en unknown
-
1994
- 1994-11-03 NO NO1994021C patent/NO1994021I1/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR860007247A (en) | 1986-10-10 |
HUT42461A (en) | 1987-07-28 |
PT82254B (en) | 1988-04-21 |
FI81800B (en) | 1990-08-31 |
IL78250A0 (en) | 1986-07-31 |
DE3686341T2 (en) | 1993-01-14 |
ES8705881A1 (en) | 1987-05-16 |
NZ215462A (en) | 1988-09-29 |
IL78250A (en) | 1991-05-12 |
PT82254A (en) | 1986-04-01 |
DE3686341D1 (en) | 1992-09-17 |
NO861230L (en) | 1986-09-29 |
FI861328A0 (en) | 1986-03-26 |
ES553419A0 (en) | 1987-05-16 |
NO162765C (en) | 1990-02-14 |
KR910000165B1 (en) | 1991-01-21 |
GR860800B (en) | 1986-07-21 |
FI81800C (en) | 1990-12-10 |
ZA862279B (en) | 1987-11-25 |
HU195793B (en) | 1988-07-28 |
NO1994021I1 (en) | 1994-11-03 |
NO162765B (en) | 1989-11-06 |
PH24016A (en) | 1990-02-09 |
ATE79379T1 (en) | 1992-08-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA793150B (en) | 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphanes,processes for their preparation,and pharmaceutical compositions thereof | |
SE8301726L (en) | NEW CEPHALOSPORIN DERIVATIVES AND PROCEDURES FOR PRODUCING THEREOF | |
ES8401961A1 (en) | Substituted N-(4-indolyl-piperidino-alkyl) benzimidazolones, processes for their preparation and their use as pharmaceutical preparations. | |
DK213087A (en) | 1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF, THEIR PREPARATION AND USE | |
KR830006248A (en) | 3, 1-benzoazin-2-one manufacturing method | |
EP0313458A3 (en) | Imidazo(2,1-b)benzothiazoles and their acid addition salts, process and intermediates for their preparation, their use as medicaments and pharmaceutical compositions containing them | |
ES8800122A1 (en) | Indene and naphthalene derivatives. | |
FI861328A (en) | NYA 1,2-BENZIOXAZOLE-3-YL-OCH 1,2-BENZISOTIAZOLE-3-YL DERIVATIVES. | |
DK408083A (en) | ISOQUINOLINE DERIVATIVES, THEIR PREPARATION AND USE | |
GB8829593D0 (en) | Novel compounds | |
NO961077D0 (en) | Substituted benzoltienylpiperazines, their use as drugs and methods of preparation | |
DK212387A (en) | BENZHYDRYLPIPERAZINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITIONAL SALTS AND QUATERNARY AMMONI-SALES THEREOF, THEIR PREPARATION AND USE | |
ES474694A1 (en) | 7-Amino-5H-benzocycloheptene derivatives and their salts, a process for their preparation, their use as medicines and pharmaceutical compositions containing them. | |
FI890690A0 (en) | NATURAL SUBSTITUTES 5-HALOGEN-THIENOISOTIAZOLE-3 (2H) -ON-1,1-DIOXIDER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE PHARMACEUTICAL PREPARAT. | |
ES554830A0 (en) | PROCEDURE FOR PREPARING 1,3-OXATIAN DERIVATIVES | |
FI870057A (en) | NYA TYRONINDERIVAT. | |
GR3000488T3 (en) | Novel 1,4-dihydropyridines containing fluorine, process for their preparation and their use as medicaments | |
SE8600086L (en) | Naphthalene derivatives of the benzon boron, processes for the preparation thereof, and pharmaceuticals and cosmetics containing them | |
IL106862A (en) | 5-phenyl 3-phenylprop-2-YL oxazolidones process for their preparation and pharmaceutical compositions containing them | |
ZA901981B (en) | Thienylacetic acid derivatives,process for the preparation thereof,the use thereof,and pharmaceuticals containing these and the preparation thereof | |
ES8609291A1 (en) | 1-Aryloxypropanol amines, process for their preparation and their use. | |
TH9985A (en) | Indino indole II compounds | |
FI882667A (en) | FOERFARANDE FOER FRAMSTAELLNING AV ANTIBAKTERISKA VID 7-STAELLNINGEN SUBSTITUERADE 1-CYCLOPROPYL-6-FLUOR -1,4-DIHYDRO-4-OXO-1,8-NAFTYRIDIN-3-CARBOXYLSYROR. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ND | Supplementary protection certificate (spc) granted | ||
SPCG | Supplementary protection certificate granted |
Spc suppl protection certif: L34 Extension date: 20071208 |
|
FG | Patent granted |
Owner name: JANSSEN PHARMACEUTICA N.V. |
|
MA | Patent expired |