ES8704542A1 - Un procedimiento para la preparacion de derivados enzimaticos. - Google Patents
Un procedimiento para la preparacion de derivados enzimaticos.Info
- Publication number
- ES8704542A1 ES8704542A1 ES549459A ES549459A ES8704542A1 ES 8704542 A1 ES8704542 A1 ES 8704542A1 ES 549459 A ES549459 A ES 549459A ES 549459 A ES549459 A ES 549459A ES 8704542 A1 ES8704542 A1 ES 8704542A1
- Authority
- ES
- Spain
- Prior art keywords
- enzyme conjugates
- therapeutical use
- therapeutical
- conjugates
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEIDMIENTO PARA PREPARAR DERIVADOS ENZIMATICOS. CONSISTE EN HACER REACCIONAR UNA O UNAS ENZIMAS FIBRINOLITICAS SIMULTANEAS CON UN AGENTE ACILANTE POLIFUNCIONAL DE FORMULA (I), EN UN MEDIO TAMPONADO ACUOSO DE PH ENTRE 6,5 Y 8,5, A UNA TEMPERATURA ENTRE 0 Y 40JC Y DURANTE 30 MINUTOS Y 7 DIAS. SIENDO: A, INDEPENDIENTEMENTE, UN GRUPO PUENTE QUE COMPRENDE UN HETEROATOMO SELECCIONADO ENTRE , S Y N; B, UN GRUPO ENLAZANTE HIDROFILICO LINEAL; L, UN GRUPO NODAL DE VALENCIA N; R5, R6, R7 Y R8, H O SUSTITUYENTES ATRACTORES DE ELECTRONES; Z, UN CONTRANION; X, UN GRUPO ACILO DE -R-CO-; R, FUNCION AROMATICA; Y N, 2 A 6. SE UTILIZAN PARA EL TRATAMIENTO DE ENFERMEDADES TROMBOTICAS.43
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848430253A GB8430253D0 (en) | 1984-11-30 | 1984-11-30 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES549459A0 ES549459A0 (es) | 1987-04-01 |
ES8704542A1 true ES8704542A1 (es) | 1987-04-01 |
Family
ID=10570498
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES549459A Expired ES8704542A1 (es) | 1984-11-30 | 1985-11-29 | Un procedimiento para la preparacion de derivados enzimaticos. |
ES557266A Expired ES8708249A1 (es) | 1984-11-30 | 1986-12-24 | Un procedimiento para la preparacion de derivados enzimaticos |
ES557267A Expired ES8801616A1 (es) | 1984-11-30 | 1986-12-24 | Un procedimiento para la preparacion de derivados amidinofenilicos |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES557266A Expired ES8708249A1 (es) | 1984-11-30 | 1986-12-24 | Un procedimiento para la preparacion de derivados enzimaticos |
ES557267A Expired ES8801616A1 (es) | 1984-11-30 | 1986-12-24 | Un procedimiento para la preparacion de derivados amidinofenilicos |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0184363A3 (es) |
JP (1) | JPS61143325A (es) |
AU (1) | AU5044685A (es) |
DK (1) | DK552485A (es) |
ES (3) | ES8704542A1 (es) |
GB (1) | GB8430253D0 (es) |
GR (1) | GR852876B (es) |
PT (1) | PT81572B (es) |
ZA (1) | ZA859159B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8503097A (nl) * | 1985-11-11 | 1987-06-01 | Leuven Res & Dev Vzw | Geneesmiddel met thrombolytische werking. |
IE64284B1 (en) * | 1987-08-03 | 1995-07-26 | Ddi Pharmaceuticals | Conjugates of superoxide dismutase |
DK468388A (da) * | 1987-08-21 | 1989-02-22 | Wellcome Found | Kompleks af polyethylenglycol og vaevplasminogen-aktivator, fremgangsmaade til dets fremstilling og farmaceutiske kompositioner indeholdende komplekset |
US5272076A (en) * | 1991-06-13 | 1993-12-21 | Eli Lilly And Company | Compounds and methods for treatment of thromboembolic disorders using an adduct of t-PA |
DE60233315D1 (de) * | 2001-03-23 | 2009-09-24 | Enzon Inc | Prodrugs von krebsmitteln mit substituierten aromatischen säuren |
AU2018361589A1 (en) * | 2017-11-02 | 2020-06-04 | Ube Corporation | Double-headed protease inhibitor |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0028489B1 (en) * | 1979-11-05 | 1983-10-05 | Beecham Group Plc | Enzyme derivatives, and their preparation |
DE3361610D1 (en) * | 1982-04-07 | 1986-02-06 | Beecham Group Plc | Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them |
US4536391A (en) * | 1982-11-17 | 1985-08-20 | Otsuka Pharmaceutical Co. | Process for preparing urokinase complex |
GB8334499D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Derivatives |
-
1984
- 1984-11-30 GB GB848430253A patent/GB8430253D0/en active Pending
-
1985
- 1985-11-25 EP EP85308534A patent/EP0184363A3/en not_active Withdrawn
- 1985-11-28 PT PT81572A patent/PT81572B/pt unknown
- 1985-11-28 AU AU50446/85A patent/AU5044685A/en not_active Abandoned
- 1985-11-28 DK DK552485A patent/DK552485A/da not_active Application Discontinuation
- 1985-11-29 JP JP60269207A patent/JPS61143325A/ja active Pending
- 1985-11-29 ES ES549459A patent/ES8704542A1/es not_active Expired
- 1985-11-29 GR GR852876A patent/GR852876B/el unknown
- 1985-11-29 ZA ZA859159A patent/ZA859159B/xx unknown
-
1986
- 1986-12-24 ES ES557266A patent/ES8708249A1/es not_active Expired
- 1986-12-24 ES ES557267A patent/ES8801616A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ZA859159B (en) | 1986-11-26 |
ES8708249A1 (es) | 1987-10-01 |
EP0184363A3 (en) | 1987-12-23 |
EP0184363A2 (en) | 1986-06-11 |
ES557266A0 (es) | 1987-10-01 |
GR852876B (es) | 1986-03-31 |
ES549459A0 (es) | 1987-04-01 |
GB8430253D0 (en) | 1985-01-09 |
PT81572A (en) | 1985-12-01 |
PT81572B (en) | 1987-07-22 |
JPS61143325A (ja) | 1986-07-01 |
AU5044685A (en) | 1986-06-05 |
DK552485A (da) | 1986-05-31 |
DK552485D0 (da) | 1985-11-28 |
ES8801616A1 (es) | 1988-02-16 |
ES557267A0 (es) | 1988-02-16 |
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