ES8703526A1 - Un procedimiento para producir un polipeptido no toxico - Google Patents

Un procedimiento para producir un polipeptido no toxico

Info

Publication number
ES8703526A1
ES8703526A1 ES544967A ES544967A ES8703526A1 ES 8703526 A1 ES8703526 A1 ES 8703526A1 ES 544967 A ES544967 A ES 544967A ES 544967 A ES544967 A ES 544967A ES 8703526 A1 ES8703526 A1 ES 8703526A1
Authority
ES
Spain
Prior art keywords
coli
formulated
production
vibrio cholerae
vaccines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544967A
Other languages
English (en)
Other versions
ES544967A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
Praxis Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praxis Biologics Inc filed Critical Praxis Biologics Inc
Publication of ES544967A0 publication Critical patent/ES544967A0/es
Publication of ES8703526A1 publication Critical patent/ES8703526A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1239—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Vibrionaceae (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56916—Enterobacteria, e.g. shigella, salmonella, klebsiella, serratia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR UN POLIPEPTIDO NO TOXICO. CONSISTE EN: A) CULTIVAR UN ORGANISMO UNICELULAR QUE CONTIENE UN VECTOR RECOMBINANTE QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN POLIPEPTIDO QUE TIENE UNO O MAS DETERMINANTES INMUNORREACTIVOS Y ANTIGENICOS DE UNA SUBUNIDAD LT-B DE LA ENTEROTOXINA LABIL AL CALOR DE UNA BACTERIA ENTEROTOXIGENA Y QUE PUEDE REPLICARSE, TRANSCRIBIRSE Y TRADUCIRSE EN EL ORGANISMO UNICELULAR; Y B) AISLAR DICHO POLIPEPTIDO DEL CULTIVO; DONDE EL VECTOR RECOMBINANTE SE INTRODUCE EN EL ORGANISMO UNICELULAR POR TRANSFORMACION; Y DONDE LA INFORMACION CONTENIDA EN LA SECUENCIA DE ADN SE OBTIENE DEL PLASMIDO ENT DE UNA BACTERIA ESCHERICHIA COLI ENTEROTOXIGENA. TIENE UTILIDAD PARA EL USO EN LA PROFILAXIS Y TERAPIA INMUNOLOGICAS.
ES544967A 1984-07-09 1985-07-08 Un procedimiento para producir un polipeptido no toxico Expired ES8703526A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62887384A 1984-07-09 1984-07-09

Publications (2)

Publication Number Publication Date
ES544967A0 ES544967A0 (es) 1987-02-16
ES8703526A1 true ES8703526A1 (es) 1987-02-16

Family

ID=24520666

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544967A Expired ES8703526A1 (es) 1984-07-09 1985-07-08 Un procedimiento para producir un polipeptido no toxico

Country Status (10)

Country Link
EP (1) EP0168322B1 (es)
JP (1) JPS62500073A (es)
AT (1) ATE62270T1 (es)
AU (1) AU598725B2 (es)
CA (1) CA1340372C (es)
DE (1) DE3582373D1 (es)
DK (1) DK311485A (es)
ES (1) ES8703526A1 (es)
IE (1) IE59393B1 (es)
WO (1) WO1986000647A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5137721A (en) * 1981-03-09 1992-08-11 Cetus Corporation Employing strains of E. coli expressing non-indigenous adhesins and toxoids of E. coli
US4748018A (en) * 1984-02-07 1988-05-31 Stolle Research & Development Corp. Method of passive immunization of mammals using avian antibody
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
AR241713A1 (es) * 1984-08-30 1992-11-30 Smithkline Beckman Corp Molecula de dna con una secuencia de bases que codifica la proteina c13 y preparacion de vacunas contra la gripe.
CA1339465C (en) * 1986-04-30 1997-09-16 Richard J. Massey Electrochemiluminescent assays
JP2849632B2 (ja) * 1988-04-08 1999-01-20 社団法人北里研究所 ワクチン製剤
IL91525A0 (en) * 1988-09-06 1990-04-29 Univ Washington Transgenic plants,pharmaceutical compositions containing the same and methods for the preparation thereof
US6043057A (en) * 1988-09-16 2000-03-28 Vitec Aktiebolag Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
DE3843894A1 (de) * 1988-12-24 1990-06-28 Behringwerke Ag Plasmide mit translations-start-stop-start codon-konfiguration zur expression von proteinen in e.coli
EP0416505A3 (en) * 1989-09-04 1991-10-02 Takeda Chemical Industries, Ltd. Expression plasmids and use thereof
MX2009003873A (es) 2006-10-12 2009-04-22 Angeletti P Ist Richerche Bio Proteina de fusion de transcriptasa inversa de telomerasa, nucleotidos que la codifican y usos de la misma.
US9107906B1 (en) 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328209A (en) * 1979-04-11 1982-05-04 Board Of Regents, The University Of Texas System Cholera vaccine
US4361550A (en) * 1979-12-04 1982-11-30 Ortho Pharmaceutical Corporation Complement-fixing monoclonal antibody to human suppressor T cells and methods of preparing same
NL8000527A (nl) * 1980-01-29 1981-08-17 Stichting Vrienden Van De Stic Werkwijze voor het bevorderen van hybridisatie van cellen in vitro en van de produktie en uitscheiding van stoffen, gevormd door dergelijke celhybriden, werkwijze voor het bevorderen van de produktie van monoclonale antilichamen in vitro door toepassing van een hybridomatechniek, alsmede endotheelcellen en/of supernatant van endotheelcellen.
US4427653A (en) * 1981-01-26 1984-01-24 President And Fellows Of Harvard College Method of making monoclonal antibodies
WO1982003088A1 (en) * 1981-03-09 1982-09-16 Corp Cetus Vaccines
US4411888A (en) * 1981-06-22 1983-10-25 The University Of Rochester Composition of a novel immunogen for protection against diarrheal disease caused by enterotoxigenic Escherichia coli
WO1983002456A2 (en) * 1982-01-18 1983-07-21 Ceska, Miroslav New plasmids and bacterial strains and production process thereo f
JPS58146596A (ja) * 1982-02-25 1983-09-01 Takeda Chem Ind Ltd 組換えｄｎａ、それで形質転換させた微生物およびそれらの用途
US4666837A (en) * 1982-05-24 1987-05-19 Smithkline-Rit DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
US4882278A (en) * 1983-04-29 1989-11-21 President And Fellows Of Harvard College Non-toxinogenic vibrio cholerae mutants
US4637980A (en) * 1983-08-09 1987-01-20 Smithkline Beckman Corporation Externalization of products of bacteria
GB8333131D0 (en) * 1983-12-12 1984-01-18 Glaxo Group Ltd Microbiological process
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers

Also Published As

Publication number Publication date
IE59393B1 (en) 1994-02-23
ES544967A0 (es) 1987-02-16
IE851710L (en) 1986-01-09
WO1986000647A1 (en) 1986-01-30
AU4458785A (en) 1986-01-16
DE3582373D1 (de) 1991-05-08
ATE62270T1 (de) 1991-04-15
DK311485A (da) 1986-01-10
CA1340372C (en) 1999-02-02
DK311485D0 (da) 1985-07-08
EP0168322B1 (en) 1991-04-03
AU598725B2 (en) 1990-07-05
EP0168322A2 (en) 1986-01-15
EP0168322A3 (en) 1986-11-20
JPS62500073A (ja) 1987-01-16

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20041113