ES8702152A1 - Procedimiento para la precipitacion extracorporea selectiva de lipoproteinas de baja densidad a partir de suero entero o plasma. - Google Patents

Procedimiento para la precipitacion extracorporea selectiva de lipoproteinas de baja densidad a partir de suero entero o plasma.

Info

Publication number
ES8702152A1
ES8702152A1 ES544160A ES544160A ES8702152A1 ES 8702152 A1 ES8702152 A1 ES 8702152A1 ES 544160 A ES544160 A ES 544160A ES 544160 A ES544160 A ES 544160A ES 8702152 A1 ES8702152 A1 ES 8702152A1
Authority
ES
Spain
Prior art keywords
low
heparin
density lipoproteins
plasma
selective precipitation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544160A
Other languages
English (en)
Other versions
ES544160A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intermedicat GmbH
Original Assignee
Intermedicat GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermedicat GmbH filed Critical Intermedicat GmbH
Publication of ES8702152A1 publication Critical patent/ES8702152A1/es
Publication of ES544160A0 publication Critical patent/ES544160A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0456—Lipoprotein
    • A61M2202/046—Low-density lipoprotein

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PRECIPITAR EXTRACORPOREAMENTE Y SELECTIVAMENTE LIPOPROTEINAS DE BAJA DENSIDAD A PARTIR DE SUERO ENTERO. COMPRENDE: A) HIDROLIZAR A LA HEPARINA NATURAL Y/O SUS SALES CON UN ACIDO ACUOSO DE 0,2 A 0,3 MM, A 70JC, CON PH ENTRE 1,5 Y 5,0 Y DURANTE 90 MIN A 30 HORAS; B) ENFRIAR LA SOLUCION ENTRE 30J Y 0JC; C) AJUSTAR EL PH DE SOLUCION DE B) ENTRE 6,0 Y 8,0 CON ALCALIS; D) DIALIZAR LA SOLUCION DE C) CON AGUA, PARA OBTENER DERIVADOS DE HEPARINA; E) TRATAR EN UN TAMPON SUERO DE PLASMA CON DERIVADOS DE HEPARINA, PARA FORMAR UN COMPLEJO DE LIPOPROTEINA Y HEPARINA; F) PRECIPITAR AL COMPLEJO DE LIPOPROTEINA Y HEPARINA EN EL PUNTO DE ISOELECTRICO A UN VALOR DE PH ENTRE 4,0 Y 5,8; Y G) SEPARAR EL PRECIPITADO DE F). EL TAMPON SE ELIGE ENTRE TAMPON DE FOSFATO, TAMPON DE LACTATO Y TAMPON DE CITRATO. SE UTILIZA EN MEDICINA PARA COMBATIR GRANDES HEMORRAGIAS DE SANGRE.
ES544160A 1984-06-16 1985-06-14 Procedimiento para la precipitacion extracorporea selectiva de lipoproteinas de baja densidad a partir de suero entero o plasma. Expired ES8702152A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843422407 DE3422407A1 (de) 1984-06-16 1984-06-16 Verwendung von heparinderivaten zur selektiven extrakorporalen praezipitation von low-density-lipoproteinen aus vollserum oder plasma

Publications (2)

Publication Number Publication Date
ES8702152A1 true ES8702152A1 (es) 1987-01-01
ES544160A0 ES544160A0 (es) 1987-01-01

Family

ID=6238513

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544160A Expired ES8702152A1 (es) 1984-06-16 1985-06-14 Procedimiento para la precipitacion extracorporea selectiva de lipoproteinas de baja densidad a partir de suero entero o plasma.

Country Status (6)

Country Link
US (1) US4908354A (es)
EP (1) EP0166324A3 (es)
JP (1) JPS6169724A (es)
DE (1) DE3422407A1 (es)
ES (1) ES8702152A1 (es)
ZA (1) ZA854508B (es)

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DE4028311C1 (en) * 1990-09-06 1991-12-05 Fresenius Ag, 6380 Bad Homburg, De Extracorporal blood carbon di:oxide removal arrangement - has feeder line connected to infusion device via which acidic infusion soln. is delivered
US5324253A (en) * 1992-03-02 1994-06-28 Mcrea James C Cannula apparatus and system for heparin removal from blood
DE4223355A1 (de) * 1992-07-16 1994-01-20 Boehringer Mannheim Gmbh Verfahren und Reagenz zur spezifischen Bestimmung von LDL in Serumproben
DE4435612A1 (de) * 1994-10-05 1996-04-11 Braun Melsungen Ag Verfahren zur simultanen Entfernung von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus einer wäßrigen Flüssigkeit
AUPN030794A0 (en) * 1994-12-22 1995-01-27 Aruba International Pty Ltd Discontinuous plasma or serum delipidation
US5911698A (en) * 1995-12-22 1999-06-15 Aruba International Pty. Ltd. Treatment for cardiovascular and related diseases
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7407663B2 (en) * 2000-06-29 2008-08-05 Lipid Sciences, Inc. Modified immunodeficiency virus particles
US20090017069A1 (en) * 2000-06-29 2009-01-15 Lipid Sciences, Inc. SARS Vaccine Compositions and Methods of Making and Using Them
US7407662B2 (en) * 2000-06-29 2008-08-05 Lipid Sciences, Inc. Modified viral particles with immunogenic properties and reduced lipid content
AUPQ846900A0 (en) * 2000-06-29 2000-07-27 Aruba International Pty Ltd A vaccine
US7439052B2 (en) * 2000-06-29 2008-10-21 Lipid Sciences Method of making modified immunodeficiency virus particles
US6706008B2 (en) 2001-03-06 2004-03-16 Baxter International Inc. Automated system and method for withdrawing compounds from blood
US6582386B2 (en) 2001-03-06 2003-06-24 Baxter International Inc. Multi-purpose, automated blood and fluid processing systems and methods
US6884228B2 (en) 2001-03-06 2005-04-26 Baxter International Inc. Automated system adaptable for use with different fluid circuits
WO2003000372A2 (en) * 2001-06-25 2003-01-03 Lipid Sciences, Inc. Systems and methods using multiple solvents for the removal of lipids from fluids
JP2004532709A (ja) * 2001-06-25 2004-10-28 リピド サイエンスィズ インコーポレイテッド 流体から脂質を除去するための溶媒を用いたシステムおよび方法
US20030127386A1 (en) * 2001-06-25 2003-07-10 Bomberger David C. Hollow fiber contactor systems for removal of lipids from fluids
US20060060520A1 (en) * 2001-06-25 2006-03-23 Bomberger David C Systems and methods using a solvent for the removal of lipids from fluids
US6991727B2 (en) * 2001-06-25 2006-01-31 Lipid Sciences, Inc. Hollow fiber contactor systems for removal of lipids from fluids
US20040106556A1 (en) * 2002-08-26 2004-06-03 Yanhong Zhu Method of treating and preventing alzheimer disease through administration of delipidated protein and lipoprotein particles
DK2368565T3 (en) * 2003-07-03 2015-09-28 Hdl Therapeutics Inc Enrichment of pre-beta lipoproteins, high density
US7393826B2 (en) * 2003-07-03 2008-07-01 Lipid Sciences, Inc. Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
US6960803B2 (en) * 2003-10-23 2005-11-01 Silicon Storage Technology, Inc. Landing pad for use as a contact to a conductive spacer
CN2698358Y (zh) * 2004-04-06 2005-05-11 上海江夏血液技术有限公司 血液过滤装置
WO2016150444A1 (en) * 2015-03-20 2016-09-29 Aarhus Universitet Inhibitors of pcsk9 for treatment of lipoprotein metabolism disorders
JP2021504003A (ja) 2017-11-22 2021-02-15 エイチディーエル セラピューティクス インコーポレイテッドＨｄｌ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 血漿処理システムの流体回路をプライミングするシステムおよび方法
CA3087207A1 (en) 2017-12-28 2019-07-04 Hdl Therapeutics, Inc. Methods for preserving and administering pre-beta high density lipoprotein extracted from human plasma

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US3506642A (en) * 1967-07-03 1970-04-14 Canada Packers Ltd Stable orally active heparinoid complexes
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Also Published As

Publication number Publication date
JPS6169724A (ja) 1986-04-10
ZA854508B (en) 1986-02-26
DE3422407A1 (de) 1986-03-06
EP0166324A3 (en) 1988-01-13
ES544160A0 (es) 1987-01-01
EP0166324A2 (en) 1986-01-02
US4908354A (en) 1990-03-13

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