ES8701751A1 - Un metodo de preparar un derivado de n-(piridina sustituida en posicion 6)-2-carbonil-histidina sustituida en posicion 3 - Google Patents

Un metodo de preparar un derivado de n-(piridina sustituida en posicion 6)-2-carbonil-histidina sustituida en posicion 3

Info

Publication number
ES8701751A1
ES8701751A1 ES541540A ES541540A ES8701751A1 ES 8701751 A1 ES8701751 A1 ES 8701751A1 ES 541540 A ES541540 A ES 541540A ES 541540 A ES541540 A ES 541540A ES 8701751 A1 ES8701751 A1 ES 8701751A1
Authority
ES
Spain
Prior art keywords
substituted
carbonyl
preparing
same
tumor agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541540A
Other languages
English (en)
Other versions
ES541540A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES541540A0 publication Critical patent/ES541540A0/es
Publication of ES8701751A1 publication Critical patent/ES8701751A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO DE FORMULA (I) Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN LA REACCION DE ELIMINACION DE LOS GRUPOS PROTECTORES DE UN DERIVADO DE N-(PIRIDINA SUSTITUIDA EN POSICION 6)-2-CARBONIL-HISTIDINA SUSTITUIDA EN POSICION 3, DE FORMULA (II), EN LA QUE Y REPRESENTA UN GRUPO PROTECTOR. LA REACCION DE ELIMINACION SE LLEVA A CABO MEDIANTE HIDROLISIS CON UN ACIDO, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y 60JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTITUMORAL.
ES541540A 1984-03-26 1985-03-25 Un metodo de preparar un derivado de n-(piridina sustituida en posicion 6)-2-carbonil-histidina sustituida en posicion 3 Expired ES8701751A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59056138A JPS60199886A (ja) 1984-03-26 1984-03-26 Ν−（６−置換ピリジン−２−カルボニル）−３−置換ヒスチジン誘導体およびその製法

Publications (2)

Publication Number Publication Date
ES541540A0 ES541540A0 (es) 1986-12-01
ES8701751A1 true ES8701751A1 (es) 1986-12-01

Family

ID=13018710

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541540A Expired ES8701751A1 (es) 1984-03-26 1985-03-25 Un metodo de preparar un derivado de n-(piridina sustituida en posicion 6)-2-carbonil-histidina sustituida en posicion 3

Country Status (10)

Country Link
EP (1) EP0158843B1 (es)
JP (1) JPS60199886A (es)
AT (1) ATE30723T1 (es)
DE (1) DE3560948D1 (es)
DK (1) DK133385A (es)
ES (1) ES8701751A1 (es)
GR (1) GR850735B (es)
HU (1) HU192918B (es)
PT (1) PT80161B (es)
ZA (1) ZA852215B (es)

Also Published As

Publication number Publication date
ZA852215B (en) 1985-11-27
HU192918B (en) 1987-07-28
PT80161A (en) 1985-04-01
EP0158843B1 (en) 1987-11-11
ES541540A0 (es) 1986-12-01
DE3560948D1 (en) 1987-12-17
DK133385A (da) 1985-09-27
HUT37918A (en) 1986-03-28
GR850735B (es) 1985-07-19
JPS60199886A (ja) 1985-10-09
JPH0376317B2 (es) 1991-12-05
PT80161B (en) 1987-04-28
ATE30723T1 (de) 1987-11-15
EP0158843A1 (en) 1985-10-23
DK133385D0 (da) 1985-03-25

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