ES8701160A1 - Procedimiento para la obtencion de derivados de n-oxidos de la piridina - Google Patents

Procedimiento para la obtencion de derivados de n-oxidos de la piridina

Info

Publication number
ES8701160A1
ES8701160A1 ES530654A ES530654A ES8701160A1 ES 8701160 A1 ES8701160 A1 ES 8701160A1 ES 530654 A ES530654 A ES 530654A ES 530654 A ES530654 A ES 530654A ES 8701160 A1 ES8701160 A1 ES 8701160A1
Authority
ES
Spain
Prior art keywords
lower alkyl
compounds
radical
salts
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530654A
Other languages
English (en)
Other versions
ES530654A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8701160A1 publication Critical patent/ES8701160A1/es
Publication of ES530654A0 publication Critical patent/ES530654A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)

Abstract

PROCEDIMIENTO PARA OBTENER DERIVADOS DE N-OXIDOS DE LA PIRIDINA. CONSISTE EN TRANSFORMAR EL RESTO ACO1 Y/O ACO2 DE FORMULA (II) EN UN RESTO AC1 Y/O AC2, PARA OBTENER DERIVADOS N-OXIDOS DE LA PIRIDINA DE FORMULA (I), PUDIENDO EFECTUARSE BAJO CONDICIONES DE REACCION ESTA FORMACION, DONDE: PY ES UN RESTO N-OXIDOPIRIDILO INSUSTITUIDO O SUSTITUIDO; R1 ES H O ALQUILO INFERIOR INSUSTITUIDO O SUSTITUIDO; Y UNO DE LOS RESTOS R2 Y R3 ES ALQUILO INFERIOR Y EL OTRO ES H, ALQUILO INFERIOR O HIDROXI LIBRE, ETERADO O ESTERIFICADO; ALQUILO INFERIOR CONTENIENDO OXO, CARBOXI FUNCIONALMENTE MODIFICADO Y OTROS, PUDIENDO UN GRUPO AMINO R2 O R3 ESTAR ENLAZADO CON UN RESTO ALQUILO INFERIOR R1 O, EN CASO DE QUE R2 O R3 SEAN ALTUILO INFERIOR, ESTE PUEDE FORMAR UN RESTO 2-OXA-1-OXO-ALQUILENO INFERIOR. TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO PROFILACTICO Y/O TERAPEUTICO DE LA HIPERTONIA Y OTRAS ENFERMEDADES CARDIOVASCULARES.
ES530654A 1981-12-30 1984-03-15 Procedimiento para la obtencion de derivados de n-oxidos de la piridina Expired ES8701160A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH835981 1981-12-30
CH225582 1982-04-14

Publications (2)

Publication Number Publication Date
ES8701160A1 true ES8701160A1 (es) 1986-11-16
ES530654A0 ES530654A0 (es) 1986-11-16

Family

ID=25689928

Family Applications (4)

Application Number Title Priority Date Filing Date
ES518711A Granted ES518711A0 (es) 1981-12-30 1982-12-30 Procedimiento para la obtencion de derivados de n-oxidos de la piridina.
ES530653A Expired ES8603456A1 (es) 1981-12-30 1984-03-15 Procedimiento para la obtencion de derivados de n-oxidos de la piridina
ES530654A Expired ES8701160A1 (es) 1981-12-30 1984-03-15 Procedimiento para la obtencion de derivados de n-oxidos de la piridina
ES530655A Expired ES8602666A1 (es) 1981-12-30 1984-03-15 Procedimiento para la obtencion de derivados de n-oxidos de la piridina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES518711A Granted ES518711A0 (es) 1981-12-30 1982-12-30 Procedimiento para la obtencion de derivados de n-oxidos de la piridina.
ES530653A Expired ES8603456A1 (es) 1981-12-30 1984-03-15 Procedimiento para la obtencion de derivados de n-oxidos de la piridina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES530655A Expired ES8602666A1 (es) 1981-12-30 1984-03-15 Procedimiento para la obtencion de derivados de n-oxidos de la piridina

Country Status (18)

Country Link
US (1) US4497808A (es)
EP (1) EP0083315B1 (es)
AT (1) ATE28643T1 (es)
AU (1) AU556201B2 (es)
CA (1) CA1215053A (es)
DD (1) DD209456A5 (es)
DE (1) DE3276862D1 (es)
DK (1) DK580282A (es)
ES (4) ES518711A0 (es)
FI (1) FI824531L (es)
GB (1) GB2112782B (es)
GR (1) GR77073B (es)
HU (1) HU192760B (es)
IE (1) IE54496B1 (es)
IL (1) IL67602A0 (es)
NO (1) NO824420L (es)
NZ (1) NZ202959A (es)
PT (1) PT76057B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0111453A1 (de) * 1982-12-10 1984-06-20 Ciba-Geigy Ag Amid-Verbindungen
EP0125803A3 (en) * 1983-04-27 1987-01-21 FISONS plc Pharmaceutically active dihydropyridines
DE3410645A1 (de) * 1984-03-23 1985-09-26 Bayer Ag, 5090 Leverkusen L-alkylsubstituierte 1,4-dihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3431152A1 (de) * 1984-08-24 1986-03-06 Cassella Ag, 6000 Frankfurt Verfahren zur herstellung optisch aktiver, substituierter 1,4-dihydropyridine und ihre verwendung als arzneimittel
US5326772A (en) * 1984-09-28 1994-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Diaryl compounds for their use
JPH0676405B2 (ja) * 1986-06-13 1994-09-28 日清製粉株式会社 １，４―ジヒドロピリジン誘導体およびそれを含有する医薬組成物
US4833150A (en) * 1985-03-14 1989-05-23 Nelson Research & Development Co. 1,4-dihydropyridines
IT1215298B (it) * 1985-08-06 1990-01-31 Boehringer Biochemia Srl 2-(eteroalchil)-1,4-diidropiridine ed un processo per la loro produzione.
DE3601397A1 (de) * 1986-01-18 1987-07-23 Bayer Ag Substituierte 1,4-dihydropyridin-3-carbonsaeurepiperazide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US4771057A (en) * 1986-02-03 1988-09-13 University Of Alberta Reduced pyridyl derivatives with cardiovascular regulating properties
US4849436A (en) * 1986-03-11 1989-07-18 Nelson Research & Development Co. 1,4-dihydropyridines
AU1626488A (en) * 1987-03-27 1988-11-02 Byk Gulden Lomberg Chemische Fabrik Gmbh 1,4-dihydropyridine enantiomers
US5158963A (en) * 1989-08-02 1992-10-27 Kaken Pharmaceutical Co., Ltd. 1-4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same
EP1663227A2 (en) * 2003-09-10 2006-06-07 Synta Pharmaceuticals Corporation Dihydropyridine compounds for treating or preventing metabolic disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545873A1 (de) * 1965-11-10 1970-02-26 Bayer Ag Verfahren zur Herstellung von Dihydrodipyridylderivaten
DE1792765A1 (de) * 1965-11-10 1974-10-10 Bayer Ag Verwendung von dihydrodipyridylen als kreislaufbeeinflussende mittel
US3862161A (en) * 1970-01-24 1975-01-21 Bayer Ag 4-pyridyl substituted 1,4-dihydropyridines
US3966948A (en) * 1970-01-24 1976-06-29 Bayer Aktiengesellschaft Spasmolytic, vaso-dilating and anti-hypertensive compositions and methods
DE2003146A1 (de) * 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate
DE2210672C3 (de) * 1972-03-06 1980-03-20 Bayer Ag, 5090 Leverkusen N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3920823A (en) * 1972-03-06 1975-11-18 Bayer Ag Use of unsymmetrical esters of n-substituted 1,4-dihydropyridine 3,5-dicarboxylic acid as cardio-vascular agents
US3933834A (en) * 1972-03-06 1976-01-20 Bayer Aktiengesellschaft Unsymmetrical esters of N-substituted 1,4-dihydropyridine 3,5-dicarboxylic acid
DE2228377A1 (de) * 1972-06-10 1974-01-03 Bayer Ag Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3946027A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
FR2320750A1 (fr) * 1975-08-12 1977-03-11 Hexachimie Dihydro-1,4 pyridines et leur application therapeutique
DE2616991A1 (de) * 1976-04-17 1977-10-27 Bayer Ag Heterocyclisch-substituierte schwefelhaltige dihydropyridine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
ATE28643T1 (de) 1987-08-15
DE3276862D1 (en) 1987-09-03
CA1215053A (en) 1986-12-09
NZ202959A (en) 1985-11-08
AU556201B2 (en) 1986-10-23
PT76057B (en) 1986-02-04
EP0083315A3 (en) 1983-08-24
US4497808A (en) 1985-02-05
IE54496B1 (en) 1989-10-25
ES8405783A1 (es) 1984-06-16
ES530653A0 (es) 1985-12-16
EP0083315A2 (de) 1983-07-06
ES530655A0 (es) 1985-12-01
PT76057A (en) 1983-01-01
HU192760B (en) 1987-07-28
EP0083315B1 (de) 1987-07-29
ES8603456A1 (es) 1985-12-16
IL67602A0 (en) 1983-05-15
ES8602666A1 (es) 1985-12-01
ES518711A0 (es) 1984-06-16
ES530654A0 (es) 1986-11-16
GB2112782A (en) 1983-07-27
FI824531L (fi) 1983-07-01
GR77073B (es) 1984-09-05
AU9195982A (en) 1983-07-07
IE823092L (en) 1983-06-30
FI824531A0 (fi) 1982-12-30
NO824420L (no) 1983-07-01
GB2112782B (en) 1985-05-01
DK580282A (da) 1983-07-01
DD209456A5 (de) 1984-05-09

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