ES8700671A1 - Un procedimiento para preparar un complejo a base de radionuclido y un derivado fosforico de diciclopentadieno bis (metalamina) - Google Patents

Un procedimiento para preparar un complejo a base de radionuclido y un derivado fosforico de diciclopentadieno bis (metalamina)

Info

Publication number
ES8700671A1
ES8700671A1 ES536010A ES536010A ES8700671A1 ES 8700671 A1 ES8700671 A1 ES 8700671A1 ES 536010 A ES536010 A ES 536010A ES 536010 A ES536010 A ES 536010A ES 8700671 A1 ES8700671 A1 ES 8700671A1
Authority
ES
Spain
Prior art keywords
radioactive metals
imaging
phosphonate derivatives
carbon atoms
infarcts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536010A
Other languages
English (en)
Other versions
ES536010A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of ES8700671A1 publication Critical patent/ES8700671A1/es
Publication of ES536010A0 publication Critical patent/ES536010A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN COMPLEJO A BASE DE UN RADIONUCLIDO Y UN DERIVADO FOSFONICO DE CICLO PENTADIENO BIS(METILAMINA). LOS AGENTES COMPLEJANTES UTILES PARA LOS RADIONUCLIDOS SE FORMAN HACIENDO REACCIONAR 3(4),8(9)-BIS(AMINOMETIL)-TRICICLO5.2.1.02,6DECANO, TAMBIEN LLAMADO DICICLOPENTADIENOBIS(METILAMINA), TAMBIEN ABREVIADO COMO DCPD-BMA, CON COMPUESTOS QUE REACCIONAN CON DCPD-BMA. LOS NUEVOS AGENTES ORGANICOS ESTABLES COMPLEJANTES PARA LOS RADIONUCLIDOS DE TC-99M, DERIVADOS DEL ACIDO METILENFOSFONICO DE LA DICICLOPENTADIENOBIS (METILAMINA), SON EXCELENTES AGENTES DE RADIOFORMACION DEL TEJIDO CARDIACO DAÑADO, DETECTORES DEL INFARTO DE MIOCARDIO, POR TECNICAS DE <PUNTO CALIENTE> Y DE FACIL ELIMINACION DEL ORGANISMO.
ES536010A 1983-09-19 1984-09-18 Un procedimiento para preparar un complejo a base de radionuclido y un derivado fosforico de diciclopentadieno bis (metalamina) Expired ES8700671A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/533,332 US4582698A (en) 1983-09-19 1983-09-19 Process for imaging cardiac infarcts

Publications (2)

Publication Number Publication Date
ES8700671A1 true ES8700671A1 (es) 1986-10-16
ES536010A0 ES536010A0 (es) 1986-10-16

Family

ID=24125502

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536010A Expired ES8700671A1 (es) 1983-09-19 1984-09-18 Un procedimiento para preparar un complejo a base de radionuclido y un derivado fosforico de diciclopentadieno bis (metalamina)

Country Status (9)

Country Link
US (1) US4582698A (es)
EP (1) EP0138384B1 (es)
JP (1) JPS6087228A (es)
AU (1) AU573622B2 (es)
BR (1) BR8404721A (es)
CA (1) CA1254508A (es)
DE (1) DE3465882D1 (es)
ES (1) ES8700671A1 (es)
ZA (1) ZA847379B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500470A (en) * 1983-04-18 1985-02-19 The Dow Chemical Company Metal ion control agents based on dicyclopentadiene derivatives
US6607080B2 (en) * 1993-04-30 2003-08-19 Varco I/P, Inc. Screen assembly for vibratory separators

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518118B2 (de) * 1964-10-22 1973-12-20 Ruhrchemie Ag, 4200 Oberhausen Verfahren zur Hydrierung von Nitrilen
GB1081124A (en) * 1965-06-04 1967-08-31 Bayer Ag Diimides of substituted naphthalene tetracarboxylic acids
US3983227A (en) * 1973-05-23 1976-09-28 The Procter & Gamble Company Dry mixture containing diphosphonates and a stannous salt useful in the preparation of Tc99M containing bone scanning agents
US4036945A (en) * 1976-05-03 1977-07-19 The Massachusetts General Hospital Composition and method for determining the size and location of myocardial infarcts
CA1078731A (en) * 1976-12-16 1980-06-03 Charles E. Frosst And Co. Skeletal imaging kit utilizing triethylene tetramine hexa (methylene phosphonic acid)
US4234562A (en) * 1978-03-20 1980-11-18 The Procter & Gamble Company Radiographic scanning
US4387087A (en) * 1980-04-18 1983-06-07 Research Corporation Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging
US4385046A (en) * 1980-12-15 1983-05-24 Minnesota Mining And Manufacturing Company Diagnostic radio-labeled polysaccharide derivatives
US4504463A (en) * 1982-06-10 1985-03-12 Mallinckrodt, Inc. Process for making a lyophilized product for use in skeletal imaging
ATE26071T1 (de) * 1982-06-10 1987-04-15 Mallinckrodt Inc Roentgen-sichtbarmachungsmittel.
US4666697A (en) * 1982-12-08 1987-05-19 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic agent
US4515767A (en) * 1983-06-20 1985-05-07 The Dow Chemical Company Radioactive metals complexed with phosphonate derivatives of dicyclopentadienebis(methylamine)

Also Published As

Publication number Publication date
US4582698A (en) 1986-04-15
JPH0559895B2 (es) 1993-09-01
ES536010A0 (es) 1986-10-16
BR8404721A (pt) 1985-08-13
AU573622B2 (en) 1988-06-16
CA1254508A (en) 1989-05-23
EP0138384A2 (en) 1985-04-24
EP0138384B1 (en) 1987-09-09
DE3465882D1 (en) 1987-10-15
AU3305084A (en) 1985-03-28
JPS6087228A (ja) 1985-05-16
EP0138384A3 (en) 1985-07-10
ZA847379B (en) 1986-05-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301