ES8607211A1 - Un procedimiento para preparar sales de compuestos de fenan-treno-metanol - Google Patents
Un procedimiento para preparar sales de compuestos de fenan-treno-metanolInfo
- Publication number
- ES8607211A1 ES8607211A1 ES545653A ES545653A ES8607211A1 ES 8607211 A1 ES8607211 A1 ES 8607211A1 ES 545653 A ES545653 A ES 545653A ES 545653 A ES545653 A ES 545653A ES 8607211 A1 ES8607211 A1 ES 8607211A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- antimalarial
- phenanthrenemethanol
- salts
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003430 antimalarial agent Substances 0.000 title abstract 2
- 230000000078 anti-malarial effect Effects 0.000 title 1
- XXDNQIGMWSPXAO-UHFFFAOYSA-N phenanthren-1-ylmethanol Chemical class C1=CC2=CC=CC=C2C2=C1C(CO)=CC=C2 XXDNQIGMWSPXAO-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- -1 alkyl radical Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR SALES DE COMPUESTOS DE FENANTRENO-METANOL. CONSISTE EN: A) HACER REACCIONAR ACIDO B-GLICEROFOSFORICO, ACIDO TARTARICO, O ACIDO QUINICO CON UN COMPUESTO DE FORMULA (II) EN UN DISOLVENTE INERTE SELECCIONADO ENTRE ALCOHOLES COMO METANOL, ETANOL Y SIMILARES Y AMIDAS COMO DIMETILFORMAMIDA Y DIMETILACETAMIDA, A UNA TEMPERATURA ENTRE AMBIENTE Y 100J. EL REACCIONANTE ACIDO SE UTILIZA EN DISOLUCION ACUOSA AL 50%, CONTENIENDO UNA CANTIDAD EQUIMOLAR SI ES ACIDO B-GLICEROFOSFORICO, 0,50 O 1 MOL POR MOL DE (II) SI ES ACIDO TARTARICO Y 2 MOLES POR MOL DE (II) SI ES ACIDO QUINICO Y B) FILTRAR Y CALENTAR EL FILTRADO A 100JC PARA ELIMINAR EL DISOLVENTE CON LO QUE OBTENEMOS COMPUESTOS DE FORMULA (I) PRECIPITADOS. SIENDO: R1 F H O UN RADICAL ALQUILO DE 1-6C; R2 F ALQUILO 1-6C Y X F NHO2CCH(OH)CH(OH)CO2H, N F 0, 5 O 1. SE UTILIZAN CONTRA PARASITOS PROVOCADORES DE MALARIA.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53301883A | 1983-09-16 | 1983-09-16 | |
| US06/533,019 US4507288A (en) | 1983-09-16 | 1983-09-16 | β-Glycerophosphate salts of antimalarial phenanthrenemethanol compounds |
| US06/548,181 US4818767A (en) | 1983-11-02 | 1983-11-02 | Quinate salts of antimalarial phenanthrenemethanol compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8607211A1 true ES8607211A1 (es) | 1986-05-16 |
| ES545653A0 ES545653A0 (es) | 1986-05-16 |
Family
ID=27415109
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535922A Expired ES8602607A1 (es) | 1983-09-16 | 1984-09-14 | Un procedimiento para preparar sales de compuestos de fenantreno-metanol |
| ES545656A Expired ES8607212A1 (es) | 1983-09-16 | 1985-07-29 | Un procedimiento para preparar sales de compuestos de fenan-treno-metanol |
| ES545653A Expired ES8607211A1 (es) | 1983-09-16 | 1985-07-29 | Un procedimiento para preparar sales de compuestos de fenan-treno-metanol |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535922A Expired ES8602607A1 (es) | 1983-09-16 | 1984-09-14 | Un procedimiento para preparar sales de compuestos de fenantreno-metanol |
| ES545656A Expired ES8607212A1 (es) | 1983-09-16 | 1985-07-29 | Un procedimiento para preparar sales de compuestos de fenan-treno-metanol |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0138374B1 (es) |
| AU (1) | AU575583B2 (es) |
| CA (1) | CA1249296A (es) |
| DE (1) | DE3479209D1 (es) |
| DK (1) | DK436284A (es) |
| ES (3) | ES8602607A1 (es) |
| FI (1) | FI843611L (es) |
| GR (1) | GR80336B (es) |
| HU (1) | HU193699B (es) |
| IL (1) | IL72920A (es) |
| NO (1) | NO159082C (es) |
| NZ (1) | NZ209519A (es) |
| PH (1) | PH19255A (es) |
| PT (1) | PT79193B (es) |
| ZW (1) | ZW15484A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2279292A (en) * | 1991-07-15 | 1993-02-23 | Smithkline Beecham Plc | Pharmaceutical formulations comprised of micronised halofantrine |
| CN1052232C (zh) * | 1993-04-06 | 2000-05-10 | 中国人民解放军军事医学科学院微生物流行病研究所 | 取代的噁嗪衍生物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4178376A (en) * | 1977-01-21 | 1979-12-11 | Interx Research Corporation | Method for inducing rapid therapeutically effective antimalarial levels of certain selected conventional antimalarials |
| US4399283A (en) * | 1980-03-11 | 1983-08-16 | Warner Lambert Company | Pharmaceutical salts of 4'-(9-acridinylamino)-methanesulfon-m-anisidide |
-
1984
- 1984-08-28 PH PH31153A patent/PH19255A/en unknown
- 1984-09-10 CA CA000462756A patent/CA1249296A/en not_active Expired
- 1984-09-11 EP EP84306182A patent/EP0138374B1/en not_active Expired
- 1984-09-11 DE DE8484306182T patent/DE3479209D1/de not_active Expired
- 1984-09-11 GR GR80336A patent/GR80336B/el unknown
- 1984-09-12 NZ NZ209519A patent/NZ209519A/en unknown
- 1984-09-12 AU AU32945/84A patent/AU575583B2/en not_active Ceased
- 1984-09-12 DK DK436284A patent/DK436284A/da not_active Application Discontinuation
- 1984-09-12 ZW ZW154/84A patent/ZW15484A1/xx unknown
- 1984-09-12 IL IL72920A patent/IL72920A/xx unknown
- 1984-09-12 PT PT79193A patent/PT79193B/pt unknown
- 1984-09-14 ES ES535922A patent/ES8602607A1/es not_active Expired
- 1984-09-14 HU HU843472A patent/HU193699B/hu not_active IP Right Cessation
- 1984-09-14 FI FI843611A patent/FI843611L/fi not_active Application Discontinuation
- 1984-09-14 NO NO843674A patent/NO159082C/no unknown
-
1985
- 1985-07-29 ES ES545656A patent/ES8607212A1/es not_active Expired
- 1985-07-29 ES ES545653A patent/ES8607211A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES535922A0 (es) | 1985-12-01 |
| DK436284D0 (da) | 1984-09-12 |
| IL72920A (en) | 1987-10-20 |
| PH19255A (en) | 1986-02-17 |
| HU193699B (en) | 1987-11-30 |
| DE3479209D1 (en) | 1989-09-07 |
| AU3294584A (en) | 1985-03-21 |
| IL72920A0 (en) | 1984-12-31 |
| CA1249296A (en) | 1989-01-24 |
| NO159082B (no) | 1988-08-22 |
| ES8607212A1 (es) | 1986-05-16 |
| HUT37386A (en) | 1985-12-28 |
| GR80336B (en) | 1985-01-11 |
| ES545656A0 (es) | 1986-05-16 |
| FI843611A0 (fi) | 1984-09-14 |
| DK436284A (da) | 1985-03-17 |
| EP0138374A2 (en) | 1985-04-24 |
| NZ209519A (en) | 1987-08-31 |
| ZW15484A1 (en) | 1984-12-05 |
| EP0138374B1 (en) | 1989-08-02 |
| ES8602607A1 (es) | 1985-12-01 |
| FI843611L (fi) | 1985-03-17 |
| PT79193A (en) | 1984-10-01 |
| PT79193B (en) | 1986-11-18 |
| NO159082C (no) | 1988-11-30 |
| ES545653A0 (es) | 1986-05-16 |
| EP0138374A3 (en) | 1987-07-15 |
| AU575583B2 (en) | 1988-08-04 |
| NO843674L (no) | 1985-03-18 |
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