ES2000587A6 - Un procedimiento para preparar derivados de piridil-alquil-imidazol - Google Patents

Un procedimiento para preparar derivados de piridil-alquil-imidazol

Info

Publication number
ES2000587A6
ES2000587A6 ES8600770A ES8600770A ES2000587A6 ES 2000587 A6 ES2000587 A6 ES 2000587A6 ES 8600770 A ES8600770 A ES 8600770A ES 8600770 A ES8600770 A ES 8600770A ES 2000587 A6 ES2000587 A6 ES 2000587A6
Authority
ES
Spain
Prior art keywords
dopamine
beta
hydroxylase inhibitors
halogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600770A
Other languages
English (en)
Inventor
Carl Kaiser
Lawrence Ivan Kruse
Stephen Torey Ross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of ES2000587A6 publication Critical patent/ES2000587A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

LOS DERIVADOS DESCRITOS, QUE TIENEN LA FORMULA: EN LA QUE Y ES HIDROGENO, HALOGENO O ALCOXI DE C1-4, X ES HIDROGENO, HALOGENO, HALO-ALQUILO DE C1-4 O CUALQUIER COMBINACION ACCESIBLE DE ELLOS, N ES 15 Y R ES HIDROGENO O ALQUILO DE C1-4, SE PREPARAN HACIENDO REACCIONAR UN COMPUESTO DE FORMULA: EN LA QUE Y1 ES HIDROGENO, HALOGENO O ALCOXI DE C1-4, X Y N SON COMO ANTES, CON TIOCIANATO ACIDO, Y ALQUILANDO OPCIONALMENTE EL COMPUESTO FORMADO. ESTOS COMPUESTOS SON UTILES COMO INHIBIDORES DE LA ACTIVIDAD DE LA DOPAMINA-B-HIDROXILASA EN MAMIFEROS.
ES8600770A 1985-08-02 1986-07-31 Un procedimiento para preparar derivados de piridil-alquil-imidazol Expired ES2000587A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/761,936 US4634711A (en) 1985-08-02 1985-08-02 Pyridylalkyl imidazole-2-thiols

Publications (1)

Publication Number Publication Date
ES2000587A6 true ES2000587A6 (es) 1988-03-01

Family

ID=25063659

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600770A Expired ES2000587A6 (es) 1985-08-02 1986-07-31 Un procedimiento para preparar derivados de piridil-alquil-imidazol

Country Status (9)

Country Link
US (1) US4634711A (es)
EP (1) EP0214740A3 (es)
JP (1) JPS6233172A (es)
AU (1) AU592586B2 (es)
DK (1) DK357086A (es)
ES (1) ES2000587A6 (es)
GR (1) GR862032B (es)
PT (1) PT83076B (es)
ZA (1) ZA865775B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61110266A (ja) * 1984-11-05 1986-05-28 Omron Tateisi Electronics Co カード発行方法
IL82401A0 (en) * 1986-05-06 1987-11-30 Merrell Dow Pharma Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them
US5057613A (en) * 1986-05-06 1991-10-15 Merrell Dow Pharmaceuticals Novel thione dopamine beta hydroxylase inhibitors
JPS63101380A (ja) * 1986-10-17 1988-05-06 Zeria Shinyaku Kogyo Kk 新規な２−メルカプトベンズイミダゾ−ル誘導体、それらの製造法およびそれらを有効成分として含有する抗潰瘍剤
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
US4749717A (en) * 1987-01-08 1988-06-07 Smithkline Beckman Corporation Dopamine-beta-hydroxylase inhibitors
CA2036148A1 (en) * 1990-06-29 1991-12-30 Hiroki Tomioka A 1-phenylimidazole derivative and its production and use
US5635521A (en) * 1991-09-23 1997-06-03 Sandoz Ltd. Imidazolylmethyl-pyridines
DE4131584A1 (de) * 1991-09-23 1993-03-25 Sandoz Ag Imidazolylmethyl-pyridine, ihre herstellung und anwendung als pharmazeutika
GB2370229A (en) * 2000-12-22 2002-06-26 Icn Photonics Ltd Light delivery system for improving the appearance of skin
WO2009097416A1 (en) * 2008-01-29 2009-08-06 Vanda Pharmaceuticals, Inc. Imidazolylalkyl- pyridines as dbh inhibitors
IN2012DE00661A (es) 2012-03-07 2015-08-21 Univ Delhi

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1155580A (en) * 1965-10-21 1969-06-18 Geigy Ag J R New Imidazole Derivatives their Production and Use
JPS5343958B2 (es) * 1972-07-29 1978-11-24
DE2259627A1 (de) * 1972-12-06 1974-06-12 Hoechst Ag Imidazolyl-(2)-thio-alkansaeureester und verfahren zu ihrer herstellung
US4284641A (en) * 1977-08-26 1981-08-18 Burroughs Wellcome Co. Pharmaceutically active imidazole derivatives
US4340738A (en) * 1979-06-21 1982-07-20 Janssen Pharmaceutica, N.V. 2,3-Dihydro-imidazo[2,1-b]benzothiazoles
GR71915B (es) * 1979-11-27 1983-08-16 Pfizer
GB2096987B (en) * 1981-04-22 1984-04-04 Farmos Oy Substituted imidazole and imidazole derivatives and their preparation and use
US4487761A (en) * 1982-04-05 1984-12-11 Merck & Co., Inc. Dopamine β-hydroxylase inhibitors
US4505918A (en) * 1982-11-08 1985-03-19 Merck & Co., Inc. 4-[2-Pyridinylthio(oxy or amino)methyl]-1H-imidazoles and derivatives
US4506074A (en) * 1982-11-08 1985-03-19 Merck & Co., Inc. 2-[2-Pyridinyloxy(thio or amino)methyl]-1H-imidazoles and derivatives
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors
US4532331A (en) * 1983-04-12 1985-07-30 Smithkline Beckman Corporation 1-Benzyl-2-aminomethyl imidazole derivatives
FI833794A0 (fi) * 1983-10-18 1983-10-18 Farmos Oy Substituerade 2-merkapto-imidazoler
IL82401A0 (en) * 1986-05-06 1987-11-30 Merrell Dow Pharma Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi

Also Published As

Publication number Publication date
AU6055886A (en) 1987-02-05
ZA865775B (en) 1987-04-29
PT83076A (en) 1986-08-01
JPS6233172A (ja) 1987-02-13
US4634711A (en) 1987-01-06
EP0214740A2 (en) 1987-03-18
AU592586B2 (en) 1990-01-18
GR862032B (en) 1986-12-24
EP0214740A3 (en) 1988-03-30
DK357086A (da) 1987-02-03
DK357086D0 (da) 1986-07-28
PT83076B (en) 1988-07-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102