ES8605519A1 - Procedimiento para preparar derivados de 4-alcoxi-pirido-(2,3-d)pirimidina - Google Patents

Procedimiento para preparar derivados de 4-alcoxi-pirido-(2,3-d)pirimidina

Info

Publication number
ES8605519A1
ES8605519A1 ES548008A ES548008A ES8605519A1 ES 8605519 A1 ES8605519 A1 ES 8605519A1 ES 548008 A ES548008 A ES 548008A ES 548008 A ES548008 A ES 548008A ES 8605519 A1 ES8605519 A1 ES 8605519A1
Authority
ES
Spain
Prior art keywords
preparation
pyrimidine derivatives
alkoxypyrido
medicaments containing
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548008A
Other languages
English (en)
Other versions
ES548008A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goedecke GmbH
Original Assignee
Goedecke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke GmbH filed Critical Goedecke GmbH
Publication of ES548008A0 publication Critical patent/ES548008A0/es
Publication of ES8605519A1 publication Critical patent/ES8605519A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 4-ALCOXI-PIRIDO2,3-DPIRIMIDINA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 ES UN RADICAL DE ANILLO AROMATICO O HETEROAROMATICO; R2 ES NITRILO, CARBOXILO O ALCOXICARBONILO C1-6; R3 REPRESENTA ALQUILO C1-4 O AMINO Y R4 ES ALQUILO C1-4. COMPRENDE LA REACCION DE O-ALQUILACION DE UN DERIVADO DE 4-OXO-PIRIDO2,3-DPIRIMIDINA, DE FORMULA (II), EN LA QUE R2 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES Y R1 Y R3 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA ALQUILACION SE LLEVA A CABO POR TRATAMIENTO CONUN HALOGENURO DE ALQUILO, EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE C20JC Y LA DE EBULLICION DEL DISOLVENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES VASCULARES CEREBRALES, CARDIACAS Y PERIFERICAS.
ES548008A 1984-10-19 1985-10-18 Procedimiento para preparar derivados de 4-alcoxi-pirido-(2,3-d)pirimidina Expired ES8605519A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843438351 DE3438351A1 (de) 1984-10-19 1984-10-19 4-alkoxy-pyrido(2,3-d)pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung

Publications (2)

Publication Number Publication Date
ES548008A0 ES548008A0 (es) 1986-03-16
ES8605519A1 true ES8605519A1 (es) 1986-03-16

Family

ID=6248308

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548008A Expired ES8605519A1 (es) 1984-10-19 1985-10-18 Procedimiento para preparar derivados de 4-alcoxi-pirido-(2,3-d)pirimidina

Country Status (14)

Country Link
US (2) US4681882A (es)
EP (1) EP0180834B1 (es)
JP (1) JPS61100582A (es)
CN (1) CN1004274B (es)
AT (1) ATE45949T1 (es)
AU (1) AU579413B2 (es)
CA (1) CA1257261A (es)
DD (1) DD239794A5 (es)
DE (2) DE3438351A1 (es)
DK (1) DK478585A (es)
ES (1) ES8605519A1 (es)
GR (1) GR852529B (es)
HU (1) HU194227B (es)
ZA (1) ZA857989B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438350A1 (de) * 1984-10-19 1986-04-24 Gödecke AG, 1000 Berlin 4-oxo-pyrido (2,3-d) pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung
DE3501696A1 (de) * 1985-01-19 1986-07-24 Bayer Ag, 5090 Leverkusen Pyridopyrimidine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US5059602A (en) * 1990-08-27 1991-10-22 Hoechst-Roussel Pharmaceuticals Inc. 4-substituted dihydropyrido(4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
DE102006026585A1 (de) * 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Substituierte 4-Aryl-1,4-dihydro-1,6-naphthyridine und ihre Verwendung
DE102006026583A1 (de) * 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Aryl-substituierte hetero-bicyclische Verbindungen und ihre Verwendung
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE525394A (es) *
US3673184A (en) * 1970-09-02 1972-06-27 Dainippon Pharmaceutical Co Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives
US4271164A (en) * 1979-04-16 1981-06-02 Warner-Lambert Company 6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives
US4361700A (en) * 1980-05-20 1982-11-30 James S. Waldron Pyridopyrimidinone derivatives
US4560753A (en) * 1982-11-05 1985-12-24 Sterling Drug Inc. 2-Substituted-pyrido[2,3-d]pyrimidin-5(8H)-ones
US4432981A (en) * 1982-11-05 1984-02-21 Sterling Drug Inc. 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones
DE3438350A1 (de) * 1984-10-19 1986-04-24 Gödecke AG, 1000 Berlin 4-oxo-pyrido (2,3-d) pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung

Also Published As

Publication number Publication date
US4681882A (en) 1987-07-21
DK478585D0 (da) 1985-10-18
CA1257261A (en) 1989-07-11
DD239794A5 (de) 1986-10-08
DK478585A (da) 1986-04-20
GR852529B (es) 1986-02-19
CN85107614A (zh) 1986-07-16
ZA857989B (en) 1986-06-25
HUT39181A (en) 1986-08-28
AU4885685A (en) 1986-04-24
DE3572663D1 (en) 1989-10-05
HU194227B (en) 1988-01-28
JPS61100582A (ja) 1986-05-19
CN1004274B (zh) 1989-05-24
ATE45949T1 (de) 1989-09-15
ES548008A0 (es) 1986-03-16
EP0180834A1 (de) 1986-05-14
DE3438351A1 (de) 1986-04-24
US4762837A (en) 1988-08-09
AU579413B2 (en) 1988-11-24
EP0180834B1 (de) 1989-08-30

Similar Documents

Publication Publication Date Title
EP0379806A3 (en) Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines
HU894581D0 (en) Alkoxy-4(1h)-pyridone derivatives, process for producing these compounds and pharmaceutical preparatives containing them as active substance
ES8605519A1 (es) Procedimiento para preparar derivados de 4-alcoxi-pirido-(2,3-d)pirimidina
HUT51138A (en) Process for production of medical composition against osteoporosis containing derivatives of imidasole /1,2-a/-piridasine or pirasine
OA07699A (fr) Dérivés de la furo-(3,4-c)-pyridine leur préparation et compositions thérapeutiques contenant ces dérivés.
EP0179808A4 (en) MEDICINAL COMPOSITION SUITABLE FOR TREATING OR PROPHYLAXIS OF HEART DISORDERS.
RU93004860A (ru) Гетероциклические соединения, способ их получения, использование и фармацевтическая композиция
EP0150709A3 (en) 7-oxabicycloheptane prostaglandin analogs
FI892684A (fi) Menetelmä terapeuttisesti aktiivisten 4-okso-imidatso/1,5-a/kinoksaliinijohdannaisten valmistamiseksi
ES8407476A1 (es) Procedimiento de preparar compuestos piridinicos.
IL72188A0 (en) Imidazoquinazoline derivative and salts thereof,their preparation and pharmaceutical compositions containing them
IL70445A0 (en) New pharmacologically active pyrazolopyridines
ES8604597A1 (es) Procedimiento de preparar compuestos tiopiranopirimidinicos farmacologicamente activos.
HU908400D0 (en) Process for the production of imidazo(4,5-c)pyridine derivatives and medical preparations containing these compounds as active agents
EP0311322A3 (en) Pyridine or pyridazine derivatives as cardio-protective agents and for the treatment of ischemic disease, and process for their preparation
ES8605518A1 (es) Procedimiento para preparar derivados de 4-oxo-pirido(2,3-d)pirimidina
ZA898274B (en) 2-aminocarboxylic acids and their derivatives,processes for their preparation and their use as medicaments
HUT47579A (en) Process for production of new imidazo /1,2-a/-pirimidins and their salts and medical compositions containing them as active substance
IT8719882A0 (it) Solfidril-composti per sopprimere gli effetti inibitori di prodotti di degradazione nad sull'attivita'ld-l.
HUT49054A (en) Process for producing pharmaceutical compositions absorbed through the derm and comprising pyrazolo(1,5-a) pyridine derivatives as active ingredient
NO170545C (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme 6,21-dimethyl-19-nor-pregna-diener
IT207222Z2 (it) Cappellotto girevole applicabile alle lattine di bibite vuote per il loro impiego come portacenere.
IL86647A (en) Pharmaceutical composition comprising 6-(1-imidazolylmethyl)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid
PT74221B (en) Process for the preparation of substituted tetrahydro-1, 2, 4- -oxadiazin-5-one derivatives having anticonvulsive activity