ES8604978A1 - Un procedimiento para aislar levamisol o una sal de adicion de acido farmaceuticamente aceptable del mismo - Google Patents
Un procedimiento para aislar levamisol o una sal de adicion de acido farmaceuticamente aceptable del mismoInfo
- Publication number
- ES8604978A1 ES8604978A1 ES537554A ES537554A ES8604978A1 ES 8604978 A1 ES8604978 A1 ES 8604978A1 ES 537554 A ES537554 A ES 537554A ES 537554 A ES537554 A ES 537554A ES 8604978 A1 ES8604978 A1 ES 8604978A1
- Authority
- ES
- Spain
- Prior art keywords
- acid
- salt
- addn
- tetramisole
- levamisole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
PROCEDIMIENTO PARA AISLAR LEVAMISOL O UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE DEL MISMO. COMPRENDE: A) MEZCLAR SALES DE ADICION DE ACIDO DEL 2,3,5,6-TETRAHIDRO-6-FENILIMIDAZO2,1-BTRRAZOL O (TETRAMISOL) CON SALES DE METALES ALCALINOS O ALCALINOFERREOS DEL ACIDO L-N-(4-METOXIFENIL)SULFONIL-GLUTAMICO, EN UNA RELACION SAL DE ADICION DE ACIDO DE TETRAMISOL/SALES METALICAS ALCALINAS O ALCALINOFERREAS DEL ACIDO L-N-(4-METOXIFENIL)SULFONIL-GLUTAMICO ENTRE 1:2 Y 1:1 Y EN UN MEDIO ORGANICO QUE CONTIENE MENOS DE UN 20% EN AGUA; B) AJUSTAR EL PH DE LA MEZCLA CON CLH Y SIMILARES, PARA CRISTALIZAR LA SAL DIASTEROMERICA, FORMADA POR EL ACIDO L-N-(4-METOXIFENIL)SULFONIL-GLUTAMICO Y EL ENANTIOMERO LEVOGIRO S-(-)2,3,5,6-TETRAHIDRO-6-FENILIMIDAZO2,1-BTIAZOL O LEVAMISOL; C) SOLUBILIZAR LA SAL DIASTEROMERICA DE B), EN UN SISTEMS DISOLVENTE COMPUESTO POR UN DISOLVENTE ORGANICO NO MISCIBLE CON AGUA Y UN MEDIO ACUOSO ALCALINO COMO NAOH; Y D) EXTRAER EL LEVAMISOL EN FASE ORGANICA. SE UTILIZAN COMO ANTIHELMINTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838329869A GB8329869D0 (en) | 1983-11-09 | 1983-11-09 | Isolating levamisole from tetramisole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8604978A1 true ES8604978A1 (es) | 1986-04-01 |
| ES537554A0 ES537554A0 (es) | 1986-04-01 |
Family
ID=10551481
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES537554A Expired ES8604978A1 (es) | 1983-11-09 | 1984-11-08 | Un procedimiento para aislar levamisol o una sal de adicion de acido farmaceuticamente aceptable del mismo |
| ES537555A Granted ES537555A0 (es) | 1983-11-09 | 1984-11-08 | Un procedimiento para la preparacion de una sal de levamisol-acido l-n((4-metoxifenil)sulfonil) glutamico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES537555A Granted ES537555A0 (es) | 1983-11-09 | 1984-11-08 | Un procedimiento para la preparacion de una sal de levamisol-acido l-n((4-metoxifenil)sulfonil) glutamico |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0142191B1 (es) |
| JP (1) | JPS60115591A (es) |
| KR (1) | KR880002236B1 (es) |
| AR (1) | AR240829A1 (es) |
| AT (1) | ATE50996T1 (es) |
| AU (1) | AU566409B2 (es) |
| CA (1) | CA1239408A (es) |
| DE (1) | DE3481617D1 (es) |
| DK (1) | DK532584A (es) |
| ES (2) | ES8604978A1 (es) |
| GB (1) | GB8329869D0 (es) |
| GR (1) | GR80883B (es) |
| IL (1) | IL73449A (es) |
| IN (1) | IN160024B (es) |
| NZ (1) | NZ210015A (es) |
| PT (1) | PT79458B (es) |
| ZA (1) | ZA848747B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010251910B2 (en) * | 2009-05-29 | 2014-07-10 | Janssen Pharmaceutica Nv | Resolution of (plus or minus)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl] carbonyl]amino]phenyl]-1-piperidinyl]acetate |
| CN102675346A (zh) * | 2012-05-28 | 2012-09-19 | 重庆大学 | 一种左旋咪唑有机酸盐，其合成方法和它的药物组合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU421744B2 (en) * | 1967-08-24 | 1972-02-24 | I. C. I. Australia Limited | Chemical process |
-
1983
- 1983-11-09 GB GB838329869A patent/GB8329869D0/en active Pending
-
1984
- 1984-09-17 IN IN655/CAL/84A patent/IN160024B/en unknown
- 1984-10-15 KR KR1019840006359A patent/KR880002236B1/ko not_active IP Right Cessation
- 1984-10-15 CA CA000465415A patent/CA1239408A/en not_active Expired
- 1984-10-16 EP EP84201496A patent/EP0142191B1/en not_active Expired - Lifetime
- 1984-10-16 DE DE8484201496T patent/DE3481617D1/de not_active Expired - Lifetime
- 1984-10-16 AT AT84201496T patent/ATE50996T1/de not_active IP Right Cessation
- 1984-10-23 AR AR298343A patent/AR240829A1/es active
- 1984-10-26 NZ NZ210015A patent/NZ210015A/en unknown
- 1984-11-01 JP JP59229059A patent/JPS60115591A/ja active Granted
- 1984-11-06 PT PT79458A patent/PT79458B/pt not_active IP Right Cessation
- 1984-11-07 IL IL73449A patent/IL73449A/xx not_active IP Right Cessation
- 1984-11-08 DK DK532584A patent/DK532584A/da not_active Application Discontinuation
- 1984-11-08 ZA ZA848747A patent/ZA848747B/xx unknown
- 1984-11-08 GR GR80883A patent/GR80883B/el unknown
- 1984-11-08 ES ES537554A patent/ES8604978A1/es not_active Expired
- 1984-11-08 ES ES537555A patent/ES537555A0/es active Granted
- 1984-11-08 AU AU35237/84A patent/AU566409B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU3523784A (en) | 1985-05-30 |
| EP0142191B1 (en) | 1990-03-14 |
| AU566409B2 (en) | 1987-10-22 |
| EP0142191A3 (en) | 1986-02-19 |
| DK532584A (da) | 1985-05-10 |
| EP0142191A2 (en) | 1985-05-22 |
| KR850003895A (ko) | 1985-06-29 |
| IN160024B (es) | 1987-06-20 |
| ES8600313A1 (es) | 1985-09-16 |
| ZA848747B (en) | 1986-06-25 |
| ATE50996T1 (de) | 1990-03-15 |
| KR880002236B1 (ko) | 1988-10-20 |
| JPH0516435B2 (es) | 1993-03-04 |
| ES537555A0 (es) | 1985-09-16 |
| DE3481617D1 (de) | 1990-04-19 |
| PT79458A (en) | 1984-12-01 |
| IL73449A0 (en) | 1985-02-28 |
| PT79458B (en) | 1986-12-11 |
| ES537554A0 (es) | 1986-04-01 |
| AR240829A1 (es) | 1991-02-28 |
| DK532584D0 (da) | 1984-11-08 |
| AR240829A2 (es) | 1991-02-28 |
| IL73449A (en) | 1988-05-31 |
| GB8329869D0 (en) | 1983-12-14 |
| GR80883B (en) | 1984-11-29 |
| CA1239408A (en) | 1988-07-19 |
| JPS60115591A (ja) | 1985-06-22 |
| NZ210015A (en) | 1987-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA865240B (en) | Process for the sulfation of glycosaminoglycans,the glycosaminoglycans obtained and their biological applications | |
| PH18512A (en) | Cathode for electrolyzing acid solutions and process for producing the same | |
| BR8804232A (pt) | Composicao liquida tixotropica aquosa,processo para limpar louca e processo para aperfeicoar a estabilidade de uma composicao tixotropica | |
| NO163869C (no) | Fremgangsmaate for dehalogenering av kvartaere aminosyrehalogenider. | |
| AU549366B2 (en) | Recovery of sulphuric acid | |
| FI860566A (fi) | Foerfarande foer framstaellning av skummande blandningar. | |
| PL234314A1 (es) | ||
| ES8604978A1 (es) | Un procedimiento para aislar levamisol o una sal de adicion de acido farmaceuticamente aceptable del mismo | |
| ZA879063B (en) | Use of 13-cis retinoic acid | |
| IT1213587B (it) | Procedimento per la produzione di acido borico puro. | |
| SE7907986L (sv) | Sett att framstella 3alfa,7beta-dihydroxicholansyra | |
| DE3261468D1 (en) | Process for the isolation of 2-naphthylamine-4,8-disulphonic acid | |
| DK159329C (da) | Fremgangsmaade til kontinuerlig enzymatisk omdannelse af alfa-hydroxycarboxylsyrer til de tilsvarende optisk aktive alfa-aminocarboxylsyrer | |
| GB2031819B (en) | Joining the tubes of cycle and other frames | |
| ES489612A0 (es) | Un procedimiento para la preparacion de acido 6-cloro-alfa- metilcarbazol-2-acetico | |
| SE8202269L (sv) | Forfarande for framstellning av fast natriumamoxicillin | |
| SU1167881A1 (ru) | Фенилгидразид морфолинодиэтилуксусной кислоты, обладающий противотуберкулезным действием | |
| DE2965740D1 (en) | Method for the determination of an amino acid or an amino sulfonic acid | |
| ATE53999T1 (de) | Verfahren zur herstellung von hexaalkyldisilan. | |
| JPS5642567A (en) | Improving method of flesh of fish parasitized with sporozoan | |
| TW362019B (en) | Stable preparation of sodium 1,4-dimethylisopropylazulene-3-sulfonate and process thereof | |
| AU2127483A (en) | Methods of using strong acids modified with acid solutions | |
| SU1264575A1 (ru) | Способ иммобилизации клеток | |
| PL249104A1 (en) | Method of obtaining concentrated solutions of acid caseine | |
| IL57838A (en) | Process for the preparation of o-methyl-n-cyclohexyl-2,5-dimethyl-furan-3-hydroxamic acid,n-cyclohexyl-n-methoxyacetoacetamide employed as intermediate therein and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20050718 |