ES8602799A1 - Un procedimiento para preparar 6-metilsulfoxido-espiro-(croman-4,4'-imidazolidin)-2',5'-diona - Google Patents

Un procedimiento para preparar 6-metilsulfoxido-espiro-(croman-4,4'-imidazolidin)-2',5'-diona

Info

Publication number
ES8602799A1
ES8602799A1 ES538137A ES538137A ES8602799A1 ES 8602799 A1 ES8602799 A1 ES 8602799A1 ES 538137 A ES538137 A ES 538137A ES 538137 A ES538137 A ES 538137A ES 8602799 A1 ES8602799 A1 ES 8602799A1
Authority
ES
Spain
Prior art keywords
hydantoin
therapeutic agents
chromanimidazolidine
methythio
methylsulfinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538137A
Other languages
English (en)
Other versions
ES538137A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Publication of ES8602799A1 publication Critical patent/ES8602799A1/es
Publication of ES538137A0 publication Critical patent/ES538137A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4

Abstract

PROCEDIMIENTO DE OBTENCION DEL COMPUESTO II.CONSISTENTE EN SOMETER A OXIDACION CON PEROXIDO DE HIDROGENO Y/O METAPERYODATO POTASICO EN UN DISOLVENTE APROPIADO A LA 6-METILTIO-ESPIRO-(CROMAN -4,4-IMIDAZOLIDIN)-2, 5-DIONA DE FORMULA I PARA OBTENER EL COMPUESTO DE FORMULA II.UTIL EN EL TRATAMIENTO DE COMPLICACIONES RESULTANTES DE LA DIABETES MELLITUS, TALES COMO CATARATAS, NEUROPATIAS, RETINOPATIAS Y NEFROPATIAS.
ES538137A 1982-04-15 1984-11-30 Un procedimiento para preparar 6-metilsulfoxido-espiro-(croman-4,4'-imidazolidin)-2',5'-diona Granted ES538137A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/368,629 US4464385A (en) 1982-04-15 1982-04-15 Treatment of diabetic complications with hydantoins

Publications (2)

Publication Number Publication Date
ES8602799A1 true ES8602799A1 (es) 1985-12-01
ES538137A0 ES538137A0 (es) 1985-12-01

Family

ID=23452055

Family Applications (3)

Application Number Title Priority Date Filing Date
ES521445A Expired ES8500951A1 (es) 1982-04-15 1983-04-14 Un procedimiento para preparar 6-metil-tio-espiro-ckroman-4,4' imidazolin-2',5'-diona.
ES538137A Granted ES538137A0 (es) 1982-04-15 1984-11-30 Un procedimiento para preparar 6-metilsulfoxido-espiro-(croman-4,4'-imidazolidin)-2',5'-diona
ES538138A Expired ES8507552A1 (es) 1982-04-15 1984-11-30 Un procedimiento para preparar 6-metilsulfonil-espiro-(croman-4,4'-imidazolidin)-2',5'-diona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES521445A Expired ES8500951A1 (es) 1982-04-15 1983-04-14 Un procedimiento para preparar 6-metil-tio-espiro-ckroman-4,4' imidazolin-2',5'-diona.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES538138A Expired ES8507552A1 (es) 1982-04-15 1984-11-30 Un procedimiento para preparar 6-metilsulfonil-espiro-(croman-4,4'-imidazolidin)-2',5'-diona

Country Status (15)

Country Link
US (1) US4464385A (es)
EP (1) EP0092386B1 (es)
KR (1) KR890000156B1 (es)
AT (1) ATE36333T1 (es)
AU (1) AU552937B2 (es)
CA (1) CA1201715A (es)
DE (1) DE3377650D1 (es)
ES (3) ES8500951A1 (es)
GR (1) GR78183B (es)
IE (1) IE55227B1 (es)
IL (1) IL68422A0 (es)
NZ (1) NZ203875A (es)
PT (1) PT76551B (es)
WO (1) WO1983003542A1 (es)
ZA (1) ZA832491B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540700A (en) * 1982-04-15 1985-09-10 Alcon Laboratories, Inc. Treatment of diabetic complications with certain spiro-imidazolidine-diones
JPH0772190B2 (ja) * 1985-02-26 1995-08-02 エーザイ株式会社 ヒダントイン誘導体
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2716648A (en) * 1955-08-30 Hydantoin derivatives
US2683718A (en) * 1952-01-11 1954-07-13 Searle & Co Spiro-[xanthene-9, 4'-imidazolidine]-2, 5-dione
US3349124A (en) * 1957-05-20 1967-10-24 Pfizer & Co C Oral antidiabetic agent
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4209630A (en) * 1976-10-18 1980-06-24 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4147795A (en) * 1977-02-11 1979-04-03 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4127665A (en) * 1978-01-18 1978-11-28 Pfizer Inc. Thienohydantoin derivatives
US4147797A (en) * 1978-08-11 1979-04-03 Pfizer Inc. Spiro-furanohydantoin derivatives
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4327107A (en) * 1979-02-06 1982-04-27 A. H. Robins Company, Inc. Method useful in the treatment of sugar cataracts using 4-substituted-2-iminoimidazolidine compounds
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4307108A (en) * 1979-12-26 1981-12-22 Pfizer Inc. Method for lowering sorbitol levels using spiro-imides
JPS5899480A (ja) * 1981-12-04 1983-06-13 Senjiyu Seiyaku Kk 新規クロマン誘導体

Also Published As

Publication number Publication date
CA1201715A (en) 1986-03-11
GR78183B (es) 1984-09-26
NZ203875A (en) 1985-12-13
ES538138A0 (es) 1985-09-01
ES538137A0 (es) 1985-12-01
ATE36333T1 (de) 1988-08-15
PT76551A (en) 1983-05-01
AU1325883A (en) 1983-10-20
ZA832491B (en) 1983-12-28
PT76551B (en) 1986-01-21
AU552937B2 (en) 1986-06-26
ES8507552A1 (es) 1985-09-01
IL68422A0 (en) 1983-07-31
ES521445A0 (es) 1984-11-01
DE3377650D1 (en) 1988-09-15
IE55227B1 (en) 1990-07-04
EP0092386B1 (en) 1988-08-10
EP0092386A3 (en) 1985-03-06
ES8500951A1 (es) 1984-11-01
KR840004431A (ko) 1984-10-15
WO1983003542A1 (en) 1983-10-27
EP0092386A2 (en) 1983-10-26
KR890000156B1 (en) 1989-03-08
IE830836L (en) 1983-10-15
US4464385A (en) 1984-08-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000601