ES8602693A1 - Un procedimiento para la preparacion de derivados de acido beta-(benzotiazoliltio)-y beta-(bencimidazoliltio)-carboxi- lico - Google Patents

Un procedimiento para la preparacion de derivados de acido beta-(benzotiazoliltio)-y beta-(bencimidazoliltio)-carboxi- lico

Info

Publication number
ES8602693A1
ES8602693A1 ES543005A ES543005A ES8602693A1 ES 8602693 A1 ES8602693 A1 ES 8602693A1 ES 543005 A ES543005 A ES 543005A ES 543005 A ES543005 A ES 543005A ES 8602693 A1 ES8602693 A1 ES 8602693A1
Authority
ES
Spain
Prior art keywords
alkyl
beta
substd
cyclo
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543005A
Other languages
English (en)
Other versions
ES543005A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8602693A1 publication Critical patent/ES8602693A1/es
Publication of ES543005A0 publication Critical patent/ES543005A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BETA-(BENZOTIAZOLILTIO)- Y BETA-(BENCIMIDAZOLILTIO)-CARBOXILICO, DE FORMULA (I), EN LA QUE X ES AZUFRE O NH; Y R, R1, R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. COMPRENDE LA REACCION DE UN MERCAPTANO, DE FORMULA (II), CON UN DERIVADO DE ACIDO CARBOXILICO INSATURADO, DE FORMULA (III), EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UNA DISOLUCION ACUOSA O ACUO-ORGANICA DE UN ACIDO FUERTE, TAL COMO ACIDO SULFURICO AL 60-90% O ACIDO CLORHIDRICO AL 25-38%, A UNA TEMPERATURA COMPRENDIDA ENTRE 0C Y 100C. ESTOS COMPUESTOS TIENEN APLICACIONES COMO INHIBIDORES DE LA CORROSION EN SISTEMAS ACUOSOS O EN REVESTIMIENTOS PARA METALES.
ES543005A 1984-05-11 1985-05-10 Un procedimiento para la preparacion de derivados de acido beta-(benzotiazoliltio)-y beta-(bencimidazoliltio)-carboxi- lico Granted ES543005A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848412065A GB8412065D0 (en) 1984-05-11 1984-05-11 Preparation of carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
ES8602693A1 true ES8602693A1 (es) 1985-12-16
ES543005A0 ES543005A0 (es) 1985-12-16

Family

ID=10560807

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543005A Granted ES543005A0 (es) 1984-05-11 1985-05-10 Un procedimiento para la preparacion de derivados de acido beta-(benzotiazoliltio)-y beta-(bencimidazoliltio)-carboxi- lico

Country Status (7)

Country Link
US (1) US4652653A (es)
EP (1) EP0161220B1 (es)
AT (1) ATE66217T1 (es)
BR (1) BR8502224A (es)
DE (1) DE3583767D1 (es)
ES (1) ES543005A0 (es)
GB (1) GB8412065D0 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8313322D0 (en) * 1983-05-14 1983-06-22 Ciba Geigy Ag Heterocyclic-(cyclo)aliphatic carboxylic acids
US5347008A (en) * 1983-05-14 1994-09-13 Ciba-Geigy Corporation Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents
HU193951B (en) * 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them
EP0894793A1 (de) 1997-07-30 1999-02-03 Ciba SC Holding AG Phosphorfreie multifunktionelle Schmiermitteladditive
WO2010036613A1 (en) 2008-09-26 2010-04-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CN102264228A (zh) 2008-10-22 2011-11-30 默沙东公司 用于抗糖尿病药的新的环状苯并咪唑衍生物
US8563746B2 (en) 2008-10-29 2013-10-22 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
AU2009309037A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
AU2011218830B2 (en) 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CN104649999A (zh) * 2013-11-25 2015-05-27 刘现梅 一种水溶性2-巯基苯并噻唑衍生物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2725364A (en) * 1952-12-31 1955-11-29 Monsanto Chemicals Vinyl halide polymers plasticized with diesters of acid derivatives of 2-benzothiazolyl mercaptan
US3136689A (en) * 1959-12-28 1964-06-09 Monsanto Co Heterocyclic esters effective against micro-organisms
US3161495A (en) * 1959-12-28 1964-12-15 Monsanto Co Method of inhibiting growth of undesirable plants
US3068239A (en) * 1959-12-28 1962-12-11 Monsanto Chemicals Benzothiazole-, benzoxazole- and benzimidazole-2-thioacrylates and process
DE3216416A1 (de) * 1982-05-03 1983-11-03 Bayer Ag, 5090 Leverkusen Heteroarylthiovinyl-verbindungen, ein verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
GB8313321D0 (en) * 1983-05-14 1983-06-22 Ciba Geigy Ag Preparation of mercaptan substituted carboxylic acids
GB8313322D0 (en) * 1983-05-14 1983-06-22 Ciba Geigy Ag Heterocyclic-(cyclo)aliphatic carboxylic acids

Also Published As

Publication number Publication date
BR8502224A (pt) 1986-01-14
EP0161220A2 (de) 1985-11-13
EP0161220B1 (de) 1991-08-14
ES543005A0 (es) 1985-12-16
ATE66217T1 (de) 1991-08-15
EP0161220A3 (en) 1987-04-29
GB8412065D0 (en) 1984-06-20
US4652653A (en) 1987-03-24
DE3583767D1 (de) 1991-09-19

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506