ES8601975A1 - Un procedimiento para la preparacion de derivados de 1-normon-2-ilo - Google Patents
Un procedimiento para la preparacion de derivados de 1-normon-2-iloInfo
- Publication number
- ES8601975A1 ES8601975A1 ES538698A ES538698A ES8601975A1 ES 8601975 A1 ES8601975 A1 ES 8601975A1 ES 538698 A ES538698 A ES 538698A ES 538698 A ES538698 A ES 538698A ES 8601975 A1 ES8601975 A1 ES 8601975A1
- Authority
- ES
- Spain
- Prior art keywords
- normonyl
- derivatives
- processes
- substit
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 1-NORMON-2-ILO.UN COMPUESTO DE FORMULA (II), DONDE R1 ES ALQUILO C1-20, ALQUENILO C2-8, ARILO, ARALQUILO, HETEROCICLO (SUSTITUIDOS OPCIONALMENTE), HIDROGENO O CICLOALQUILO C3-7, Y LOS SUSTITUYENTES Z1, Z2 Y Z3 SON IGUALES O DIFERENTES, SIENDO CADA UNO DE ELLOS HIDROGENO O UN GRUPO PROTECTOR DE HIDROXILO, SE HACE REACCIONAR A BAJA TEMPERATURA (20 C A 20 C) CON FOSGENO Y UNA AMINA TERCIARIA (PREFERENTEMENTE TRIETILAMINA) Y POSTERIORMENTE CON LA ACIDA DE TETRAMETILGUANIDINIO, PARA OBTENER UN COMPUESTO DE FORMULA (I) QUE VARIA SEGUN LA NATURALEZA DEL SUSTITUYENTE R1 Y SEGUN LA CONFIGURACION Z O E DEL DOBLE ENLACE TRISUSTITUIDO. SE DESCRIBE TAMBIEN UN METODO DE OBTENCION DE OTROS COMPUESTOS DE FORMULA (I) POR MODIFICACIONES POSTERIORES DEL SUSTITUYENTE R1.SE UTILIZAN COMO FARMACOS ANTIBACTERIANOS Y ANTIMICOPLASMICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838305316A GB8305316D0 (en) | 1983-02-25 | 1983-02-25 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES538698A0 ES538698A0 (es) | 1985-11-01 |
ES8601975A1 true ES8601975A1 (es) | 1985-11-01 |
Family
ID=10538629
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530030A Granted ES530030A0 (es) | 1983-02-25 | 1984-02-24 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo. |
ES538699A Expired ES8601981A1 (es) | 1983-02-25 | 1984-12-17 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo |
ES538698A Expired ES8601975A1 (es) | 1983-02-25 | 1984-12-17 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo |
ES538697A Granted ES538697A0 (es) | 1983-02-25 | 1984-12-17 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530030A Granted ES530030A0 (es) | 1983-02-25 | 1984-02-24 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo. |
ES538699A Expired ES8601981A1 (es) | 1983-02-25 | 1984-12-17 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES538697A Granted ES538697A0 (es) | 1983-02-25 | 1984-12-17 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo |
Country Status (12)
Country | Link |
---|---|
US (1) | US4861788A (es) |
EP (1) | EP0123378B1 (es) |
JP (1) | JPS59196889A (es) |
AU (1) | AU579311B2 (es) |
CA (1) | CA1240318A (es) |
DE (1) | DE3479657D1 (es) |
DK (1) | DK96184A (es) |
ES (4) | ES530030A0 (es) |
GB (1) | GB8305316D0 (es) |
GR (1) | GR79823B (es) |
NZ (1) | NZ207261A (es) |
ZA (1) | ZA841366B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8815626D0 (en) * | 1988-06-30 | 1988-08-03 | Beecham Group Plc | Novel compounds |
IL94051A0 (en) * | 1989-04-12 | 1991-01-31 | Beecham Group Plc | 1-normon-2-yl-heterocycles,process for their preparation and pharmaceutical compositions containing them |
GB8928839D0 (en) * | 1989-12-21 | 1990-02-28 | Beecham Group Plc | Novel compounds |
GB9325832D0 (en) * | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Novel compounds |
US6951946B2 (en) * | 2002-03-19 | 2005-10-04 | Lexicon Pharmaceuticals, Inc. | Large scale synthesis of 1,2,4- and 1,3,4-oxadiazole carboxylates |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2860726D1 (en) * | 1977-11-05 | 1981-08-27 | Beecham Group Plc | Antibacterially active amides, process for their preparation and pharmaceutical compositions containing said amides |
EP0045150A1 (en) * | 1980-07-24 | 1982-02-03 | Beecham Group Plc | Antibacterial compounds, processes for their preparation and composititions containing them |
PT73431B (en) * | 1980-08-02 | 1982-10-08 | Beecham Group Plc | Antibacterial compounds processes for their preparation and compositions containing them |
US4436751A (en) * | 1980-12-31 | 1984-03-13 | Beecham Group Limited | Nitrobenzyl monates antibacterial compounds |
EP0087953B1 (en) * | 1982-02-27 | 1988-04-27 | Beecham Group Plc | Antibacterial 1-normon-2-yl-heterocyclic compounds |
-
1983
- 1983-02-25 GB GB838305316A patent/GB8305316D0/en active Pending
-
1984
- 1984-02-16 EP EP84300991A patent/EP0123378B1/en not_active Expired
- 1984-02-16 DE DE8484300991T patent/DE3479657D1/de not_active Expired
- 1984-02-23 AU AU24860/84A patent/AU579311B2/en not_active Ceased
- 1984-02-23 GR GR73908A patent/GR79823B/el unknown
- 1984-02-23 CA CA000448133A patent/CA1240318A/en not_active Expired
- 1984-02-23 NZ NZ207261A patent/NZ207261A/en unknown
- 1984-02-23 DK DK96184A patent/DK96184A/da not_active Application Discontinuation
- 1984-02-24 JP JP59034093A patent/JPS59196889A/ja active Granted
- 1984-02-24 ZA ZA841366A patent/ZA841366B/xx unknown
- 1984-02-24 ES ES530030A patent/ES530030A0/es active Granted
- 1984-12-17 ES ES538699A patent/ES8601981A1/es not_active Expired
- 1984-12-17 ES ES538698A patent/ES8601975A1/es not_active Expired
- 1984-12-17 ES ES538697A patent/ES538697A0/es active Granted
-
1987
- 1987-01-30 US US07/008,893 patent/US4861788A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4861788A (en) | 1989-08-29 |
ES538698A0 (es) | 1985-11-01 |
ES8507545A1 (es) | 1985-09-01 |
DK96184A (da) | 1984-08-26 |
ES538699A0 (es) | 1985-11-01 |
EP0123378A2 (en) | 1984-10-31 |
DE3479657D1 (en) | 1989-10-12 |
NZ207261A (en) | 1987-10-30 |
DK96184D0 (da) | 1984-02-23 |
ES8601980A1 (es) | 1985-11-01 |
JPH0534357B2 (es) | 1993-05-21 |
ZA841366B (en) | 1985-01-30 |
CA1240318A (en) | 1988-08-09 |
EP0123378A3 (en) | 1985-09-18 |
ES538697A0 (es) | 1985-11-01 |
GR79823B (es) | 1984-10-31 |
GB8305316D0 (en) | 1983-03-30 |
ES530030A0 (es) | 1985-09-01 |
AU2486084A (en) | 1984-08-30 |
JPS59196889A (ja) | 1984-11-08 |
ES8601981A1 (es) | 1985-11-01 |
AU579311B2 (en) | 1988-11-24 |
EP0123378B1 (en) | 1989-09-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8602634A1 (es) | Un procedimiento para la preparacion de sulfamatos. | |
MY102842A (en) | Calcium independent camp phosphodiesterase inhibitor antidepressant | |
PH22490A (en) | Paf-antagonistic diazepines | |
GB1471743A (en) | Isoxazole derivatives | |
ATE12224T1 (de) | Verbindungen mit antifibrinolytischer wirksamkeit. | |
ES8801818A1 (es) | Procedimiento para la obtencion de 5-amino-1-piridil-pirazoles | |
NO954985L (no) | O6-substituerte guaninderivater, fremgangsmåte for fremstilling derav og anvendelse derav ved behandling av tumorceller | |
ZA867617B (en) | 3-vinyl-and 3-ethinyl-beta-carboline derivatives their production and their use as drugs | |
ES8601975A1 (es) | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo | |
ES8706699A1 (es) | Procedimiento para preparar un derivado de cefalosporina. | |
AR246120A1 (es) | Derivados de n'-alquil-n,n'diacilhidracina insecticidamente activos y composicion que los comprende. | |
ES465927A1 (es) | Un procedimiento para la produccion de compuestos tricicli- cos | |
ES457805A1 (es) | Un procedimiento para la preparacion de derivados de tiou- rea. | |
ES8701151A1 (es) | Un procedimiento para la produccion de derivados de benzoilurea. | |
SE8302379L (sv) | Ergolinderivat | |
HUP9901022A2 (hu) | Hidroxámsav-alapú kollagenáz inhibitorok | |
ES8603414A1 (es) | Un procedimiento para preparar un derivado de 1, 4-dihidropiridina disustituido en posicion 2, 6 | |
ES451209A1 (es) | Procedimiento de fabricacion de sulfoximidas sustituidas y sus sales medicamentosas. | |
DK0625146T3 (da) | Nye syreanhydrider samt fremstilling og anvendelse heraf | |
ATE65986T1 (de) | Propanolabkoemmlinge. | |
ES8501403A1 (es) | Procedimiento de preparacion de compuestos piridotienopiridacinicos. | |
ATE129001T1 (de) | Azophenylverbindungen. | |
DE3869330D1 (de) | Bis-indolyl-ethylen-aldehyde. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19960603 |