ES8600749A1 - Procedimiento para la preparacion de compuestos de pirazina-bis (oxoglicina)antialergicos,especialmente n-n'-2 pirazina-diil) bis (2-oxoglicina), dietil ester. - Google Patents
Procedimiento para la preparacion de compuestos de pirazina-bis (oxoglicina)antialergicos,especialmente n-n'-2 pirazina-diil) bis (2-oxoglicina), dietil ester.Info
- Publication number
- ES8600749A1 ES8600749A1 ES523659A ES523659A ES8600749A1 ES 8600749 A1 ES8600749 A1 ES 8600749A1 ES 523659 A ES523659 A ES 523659A ES 523659 A ES523659 A ES 523659A ES 8600749 A1 ES8600749 A1 ES 8600749A1
- Authority
- ES
- Spain
- Prior art keywords
- oxoglycine
- bis
- compounds
- antiallergic
- pyrazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE PIRAZINA-BIS(2-OXOGLICINA) ANTIALERGICOS, ESPECIALMENTE N,N-(2,6-PIRAZINA-DIIL)BIS(2-OXOGLICINA), DIETIL ESTER.CONSISTE EN: A) HACER REACCIONAR 2,6-DIAMINOPIRAZINA DE FORMULA (II) CON (C 1 A 4) CLORURO DE ETIL OXALILO DE FORMULA (III) PARA OBTENER EL COMPUESTO DE FORMULA (I). SIENDO: X, H, BR O CL; B) TRATAR EL COMPUESTO RESULTANTE CON HIDROXIDOS METALICOS, COMO HIDROXIDO DE SODIO, PARA OBTENER LAS SALES CORRESPONDIENTES O CON UN ACIDO INORGANICO FUERTE, COMO EL CLORHIDRICO, PARA OBTENER EL CORRESPONDIENRE ACIDO CARBOXILICO LIBRE.SE UTILIZA EN FARMACOLOGIA COMO ANTIHISTAMINICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39395882A | 1982-06-30 | 1982-06-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES523659A0 ES523659A0 (es) | 1985-11-01 |
ES8600749A1 true ES8600749A1 (es) | 1985-11-01 |
Family
ID=23556946
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES523659A Expired ES8600749A1 (es) | 1982-06-30 | 1983-06-28 | Procedimiento para la preparacion de compuestos de pirazina-bis (oxoglicina)antialergicos,especialmente n-n'-2 pirazina-diil) bis (2-oxoglicina), dietil ester. |
ES539117A Granted ES539117A0 (es) | 1982-06-30 | 1984-12-27 | Procedimiento para la preparacion de compuestos de pirazina-bis(2-oxoglicina)antialergico. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES539117A Granted ES539117A0 (es) | 1982-06-30 | 1984-12-27 | Procedimiento para la preparacion de compuestos de pirazina-bis(2-oxoglicina)antialergico. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0097942B1 (es) |
JP (1) | JPS597176A (es) |
KR (1) | KR900001201B1 (es) |
AT (1) | ATE28454T1 (es) |
AU (1) | AU554357B2 (es) |
CA (1) | CA1249588A (es) |
DE (1) | DE3372614D1 (es) |
DK (1) | DK160822C (es) |
ES (2) | ES8600749A1 (es) |
GR (1) | GR78588B (es) |
IE (1) | IE55520B1 (es) |
IL (1) | IL69103A0 (es) |
NO (1) | NO832363L (es) |
NZ (1) | NZ204721A (es) |
PH (1) | PH19319A (es) |
ZA (1) | ZA834644B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4788198A (en) * | 1983-09-01 | 1988-11-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | Diazine-ethyenylphenyl oxamic acids and esters and salts thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4191840A (en) * | 1973-03-23 | 1980-03-04 | American Home Products Corporation | Oxamic acid derivatives |
US3963660A (en) * | 1973-10-04 | 1976-06-15 | The Upjohn Company | Pyridine dioxamic acids and esters |
US4017538A (en) * | 1975-10-01 | 1977-04-12 | The Upjohn Company | Alkyl thio sulfinyl and sulfonyl oxamic compounds, compositions and methods of use |
-
1983
- 1983-06-24 ZA ZA834644A patent/ZA834644B/xx unknown
- 1983-06-27 AU AU16290/83A patent/AU554357B2/en not_active Ceased
- 1983-06-27 AT AT83106229T patent/ATE28454T1/de not_active IP Right Cessation
- 1983-06-27 JP JP58114455A patent/JPS597176A/ja active Granted
- 1983-06-27 CA CA000431281A patent/CA1249588A/en not_active Expired
- 1983-06-27 DE DE8383106229T patent/DE3372614D1/de not_active Expired
- 1983-06-27 NZ NZ204721A patent/NZ204721A/en unknown
- 1983-06-27 EP EP83106229A patent/EP0097942B1/en not_active Expired
- 1983-06-28 IL IL69103A patent/IL69103A0/xx not_active IP Right Cessation
- 1983-06-28 ES ES523659A patent/ES8600749A1/es not_active Expired
- 1983-06-28 KR KR1019830002929A patent/KR900001201B1/ko not_active IP Right Cessation
- 1983-06-28 PH PH29126A patent/PH19319A/en unknown
- 1983-06-29 DK DK300183A patent/DK160822C/da not_active IP Right Cessation
- 1983-06-29 GR GR71799A patent/GR78588B/el unknown
- 1983-06-29 NO NO832363A patent/NO832363L/no unknown
- 1983-06-29 IE IE1522/83A patent/IE55520B1/en not_active IP Right Cessation
-
1984
- 1984-12-27 ES ES539117A patent/ES539117A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
EP0097942B1 (en) | 1987-07-22 |
PH19319A (en) | 1986-03-18 |
IL69103A0 (en) | 1983-10-31 |
ES8601154A1 (es) | 1985-11-16 |
AU554357B2 (en) | 1986-08-21 |
DK300183D0 (da) | 1983-06-29 |
JPS597176A (ja) | 1984-01-14 |
NO832363L (no) | 1984-01-02 |
DK300183A (da) | 1983-12-31 |
KR900001201B1 (ko) | 1990-02-28 |
JPH0551586B2 (es) | 1993-08-03 |
DK160822B (da) | 1991-04-22 |
KR840005110A (ko) | 1984-11-03 |
ZA834644B (en) | 1984-03-28 |
NZ204721A (en) | 1987-05-29 |
EP0097942A1 (en) | 1984-01-11 |
ES523659A0 (es) | 1985-11-01 |
DE3372614D1 (en) | 1987-08-27 |
ES539117A0 (es) | 1985-11-16 |
IE55520B1 (en) | 1990-10-10 |
GR78588B (es) | 1984-09-27 |
IE831522L (en) | 1983-12-30 |
DK160822C (da) | 1991-10-14 |
AU1629083A (en) | 1984-01-05 |
CA1249588A (en) | 1989-01-31 |
ATE28454T1 (de) | 1987-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970519 |