ES8600745A1 - Di:hydro-pyridine di:carboxylic acid ester prepn. - Google Patents

Di:hydro-pyridine di:carboxylic acid ester prepn.

Info

Publication number
ES8600745A1
ES8600745A1 ES537914A ES537914A ES8600745A1 ES 8600745 A1 ES8600745 A1 ES 8600745A1 ES 537914 A ES537914 A ES 537914A ES 537914 A ES537914 A ES 537914A ES 8600745 A1 ES8600745 A1 ES 8600745A1
Authority
ES
Spain
Prior art keywords
pyridine
hydro
carboxylic acid
acid ester
prepn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537914A
Other languages
Spanish (es)
Other versions
ES537914A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COMA JULIA CONCEPCIO
Original Assignee
COMA JULIA CONCEPCIO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by COMA JULIA CONCEPCIO filed Critical COMA JULIA CONCEPCIO
Priority to ES537914A priority Critical patent/ES8600745A1/en
Publication of ES537914A0 publication Critical patent/ES537914A0/en
Publication of ES8600745A1 publication Critical patent/ES8600745A1/en
Expired legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

The dimethyl ester of 2,6-dimethyl 4-(2'-nitrophenyl) 1,4-dihydropyridine 3,5-dicarboxylic acid is made by reaction of 1 mole 2-nitrobenzaldehyde diacetate with 2 moles methyl acetoacetate. Reaction is in an inert organic solvent in presence of pyridine and aq. ammonia or hexamethylene tetramine in an autoclave at 110 deg. C for 25 h. The solvent is removed in a rotary evaporator and the residue purified by crystallisation from ethanol.
ES537914A 1984-11-23 1984-11-23 Di:hydro-pyridine di:carboxylic acid ester prepn. Expired ES8600745A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES537914A ES8600745A1 (en) 1984-11-23 1984-11-23 Di:hydro-pyridine di:carboxylic acid ester prepn.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES537914A ES8600745A1 (en) 1984-11-23 1984-11-23 Di:hydro-pyridine di:carboxylic acid ester prepn.

Publications (2)

Publication Number Publication Date
ES537914A0 ES537914A0 (en) 1985-11-01
ES8600745A1 true ES8600745A1 (en) 1985-11-01

Family

ID=8488190

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537914A Expired ES8600745A1 (en) 1984-11-23 1984-11-23 Di:hydro-pyridine di:carboxylic acid ester prepn.

Country Status (1)

Country Link
ES (1) ES8600745A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2628421A1 (en) * 1988-03-08 1989-09-15 Egyt Gyogyszervegyeszeti Gyar PROCESS FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINE DERIVATIVES AND NOVEL INTERMEDIATES USEFUL FOR THIS PREPARATION
WO1999000369A1 (en) * 1997-06-27 1999-01-07 Bayer Aktiengesellschaft Process for preparing nifedipine

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2628421A1 (en) * 1988-03-08 1989-09-15 Egyt Gyogyszervegyeszeti Gyar PROCESS FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINE DERIVATIVES AND NOVEL INTERMEDIATES USEFUL FOR THIS PREPARATION
GR890100133A (en) * 1988-03-08 1990-01-19 Egyt Gyogyszervegyeszeti Gyar 1,4-dihydropyridine derivatives preparation method
GB2243608A (en) * 1988-03-08 1991-11-06 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of nifedipine
BE1003199A5 (en) * 1988-03-08 1992-01-14 Egyt Gyogyszervegyeszeti Gyar PROCESS FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINE DERIVATIVES AND TO NEW INTERMEDIATES USEFUL FOR THIS PREPARATION.
GB2243608B (en) * 1988-03-08 1992-02-12 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of 1,4-dihydro-pyridine derivatives
WO1999000369A1 (en) * 1997-06-27 1999-01-07 Bayer Aktiengesellschaft Process for preparing nifedipine

Also Published As

Publication number Publication date
ES537914A0 (en) 1985-11-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519