ES2005543A6 - Benzofuryl di:methyl di:hydro-pyridine di:ester prepn. - Google Patents
Benzofuryl di:methyl di:hydro-pyridine di:ester prepn.Info
- Publication number
- ES2005543A6 ES2005543A6 ES8603633A ES8603633A ES2005543A6 ES 2005543 A6 ES2005543 A6 ES 2005543A6 ES 8603633 A ES8603633 A ES 8603633A ES 8603633 A ES8603633 A ES 8603633A ES 2005543 A6 ES2005543 A6 ES 2005543A6
- Authority
- ES
- Spain
- Prior art keywords
- benzofuryl
- solvent
- formula
- hydro
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
4-(7'-benzofuryl)2,6-dimethyl 1,4-dihydropyridine 3,5-dicarboxylic acid diesters of formula (III), in which at least one R group contains a chiral C atom, for use as an anti-arrhythmic and antagonist of calcium, are made by reacting one equiv. of 2-(7'-benzofuranylidene) acetoacetate of formula (I) with one equiv. of a beta-amino crotonate ester of formula (II) under reflux in a solvent with b.pt. of 65-130 deg.C, removal of solvent by rotary evaporation, recrystallising from a solvent, and separating the diastereomers by chromatography.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8603633A ES2005543A6 (en) | 1986-12-30 | 1986-12-30 | Benzofuryl di:methyl di:hydro-pyridine di:ester prepn. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8603633A ES2005543A6 (en) | 1986-12-30 | 1986-12-30 | Benzofuryl di:methyl di:hydro-pyridine di:ester prepn. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2005543A6 true ES2005543A6 (en) | 1989-03-16 |
Family
ID=8248972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8603633A Expired ES2005543A6 (en) | 1986-12-30 | 1986-12-30 | Benzofuryl di:methyl di:hydro-pyridine di:ester prepn. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2005543A6 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0630895A1 (en) * | 1993-06-24 | 1994-12-28 | Bayer Ag | 4-Bicyclic substituted dihydropyridines, process for their preparation and their use in medicaments |
-
1986
- 1986-12-30 ES ES8603633A patent/ES2005543A6/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0630895A1 (en) * | 1993-06-24 | 1994-12-28 | Bayer Ag | 4-Bicyclic substituted dihydropyridines, process for their preparation and their use in medicaments |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20100528 |