ES8600690A1 - Procedimiento de purificar factores antihemofilicos y similares - Google Patents

Procedimiento de purificar factores antihemofilicos y similares

Info

Publication number
ES8600690A1
ES8600690A1 ES538912A ES538912A ES8600690A1 ES 8600690 A1 ES8600690 A1 ES 8600690A1 ES 538912 A ES538912 A ES 538912A ES 538912 A ES538912 A ES 538912A ES 8600690 A1 ES8600690 A1 ES 8600690A1
Authority
ES
Spain
Prior art keywords
factor viii
purifying factor
purifying
purified
conductivity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538912A
Other languages
English (en)
Other versions
ES538912A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Armour Pharmaceutical Co
Original Assignee
Armour Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armour Pharmaceutical Co filed Critical Armour Pharmaceutical Co
Publication of ES538912A0 publication Critical patent/ES538912A0/es
Publication of ES8600690A1 publication Critical patent/ES8600690A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO DE PURIFICAR FACTORES ANTIHEMOFILICOS Y SIMILARES.COMPRENDE: A) PROPORCIONAR UNA SOLUCION ACUOSA DEL MATERIAL DE ORIGEN QUE TIENE UN PH SUPERIOR A 5,5 HASTA 8,0, UNA CONDUCTIVIDAD DE 25 MS/CM A 35 MS/CM; B) ADSORBER FACTOR VIII:C Y FACTOR VIII:R A PARTIR DE LA SOLUCION SOBRE AMINOHEXILAGAROSA QUE HA SIDO EQUILIBRADA AL PH DE LA SOLUCION ACUOSA; C) ELUIR EL FACTOR VIII:R A PARTIR DE LA AMINOHEXILAGAROSA; Y D) ELUIR EL FACTOR VIII:C A PARTIR DE LA AMINOHEXILAGAROSA, PROPORCIONANDO ASI UNA SOLUCION DE FACTOR VIII:C QUE SE PURIFICA CON RESPECTO AL MATERIAL DE ORIGEN. LA AMINOHEXILAGAROSA CONTIENE POR LO MENOS 10 MICROMOLES DE CADENAS DE AMINOHEXILO POR GRAMO; DONDE EL MATERIAL DE ORIGEN ES PLASMA, UN CONCENTRADO DE PLASMA O UN CRIOPRECIPITADO QUE CONTIENE AHF; Y DONDE EL MATERIAL DE ORIGEN CONTIENE TAMBIEN FIBRONECTINA Y/O FIBRINOGENO Y LA FIBRONECTINA Y/O FIBRINOGENO ES COELUIDO CON EL FACTOR VIII:R.
ES538912A 1983-12-05 1984-12-05 Procedimiento de purificar factores antihemofilicos y similares Expired ES8600690A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/557,805 US4508709A (en) 1983-12-05 1983-12-05 Process for purifying factor VIII:C

Publications (2)

Publication Number Publication Date
ES538912A0 ES538912A0 (es) 1985-11-01
ES8600690A1 true ES8600690A1 (es) 1985-11-01

Family

ID=24226953

Family Applications (1)

Application Number Title Priority Date Filing Date
ES538912A Expired ES8600690A1 (es) 1983-12-05 1984-12-05 Procedimiento de purificar factores antihemofilicos y similares

Country Status (19)

Country Link
US (1) US4508709A (es)
EP (1) EP0144957B1 (es)
JP (1) JPS60136518A (es)
KR (1) KR850004593A (es)
AT (1) ATE60996T1 (es)
AU (1) AU569129B2 (es)
CA (1) CA1248449A (es)
DE (1) DE3484179D1 (es)
DK (1) DK162896C (es)
ES (1) ES8600690A1 (es)
FI (1) FI844804L (es)
IE (1) IE57644B1 (es)
IL (1) IL73734A (es)
IN (1) IN162586B (es)
MX (1) MX7552E (es)
NO (1) NO167627C (es)
NZ (1) NZ210427A (es)
SG (1) SG14992G (es)
ZA (1) ZA849434B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614795A (en) * 1982-08-05 1986-09-30 University Of Rochester Deglycosylated Human Factor VIII:C
US4650858A (en) * 1983-03-21 1987-03-17 Nordisk Gentofte A/S Concentrate of the antihemophilic factor VIII and a process for producing it
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US5043428A (en) * 1984-08-31 1991-08-27 Behringwerke Aktiengesellschaft Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production
DE3432083A1 (de) * 1984-08-31 1986-03-06 Behringwerke Ag, 3550 Marburg Pasteurisierte, isoagglutininfreie faktor viii-praeparation und verfahren zu ihrer herstellung
US4952675A (en) * 1985-02-01 1990-08-28 New York University Method for purifying antihemophilic factor
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
US4847362A (en) * 1985-02-01 1989-07-11 New York University Method for purifying antihemophilic factor
GB2178533B (en) * 1985-07-22 1989-07-19 Asahi Chemical Ind Analytical method of enzyme precursors and device therefor
JPS63108000A (ja) * 1986-05-15 1988-05-12 Green Cross Corp:The 第８因子の精製方法
JPH0789951B2 (ja) * 1986-06-18 1995-10-04 財団法人阪大微生物病研究会 遺伝子発現産物の精製法
US4795806A (en) * 1987-07-16 1989-01-03 Miles Laboratories, Inc. Phospholipid affinity purification of Factor VIII:C
NL8701915A (nl) * 1987-08-14 1989-03-01 Waander Riethorst Adsorbensmateriaal en toepassing daarvan voor het isoleren van stollingsfaktoren.
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
DE3826792C1 (es) * 1988-08-06 1989-07-06 Biotest Pharma Gmbh, 6072 Dreieich, De
ES2053684T3 (es) * 1988-11-05 1994-08-01 Octapharma Ag Procedimiento para preparar un factor antihemofilico, altamente puro, no infeccioso, mediante cromatografia.
FR2644064B1 (fr) * 1989-02-17 1994-05-27 Aquitaine Dev Transf Sanguine Procede de fabrication du facteur antihemophilique fviiic ayant une tres haute purete et facteur antihemophilique fviiic ainsi obtenu, ainsi que composition pharmaceutique le contenant
FR2665449B1 (fr) * 1990-08-02 1995-04-14 Aquitaine Developp Transf Sang Procede de fabrication de facteur von willebrand ayant une tres haute purete, depourvu en majeure partie de facteur antihemophilique (fviiic), et facteur von willebrand ainsi obtenu, ainsi qu'une composition pharmaceutique le contenant.
GB8913183D0 (en) * 1989-06-08 1989-07-26 Central Blood Lab Authority Chemical products
DE3939346A1 (de) * 1989-11-29 1991-06-06 Behringwerke Ag Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide
JPH0427865A (ja) * 1989-12-21 1992-01-30 Kurita Water Ind Ltd 血液凝固因子用分離剤およびその製造方法
FR2681867B1 (fr) * 1991-09-26 1993-12-31 Pasteur Merieux Serums Vaccins Procede de purification du facteur viii et preparations obtenues.
US5278289A (en) * 1991-11-12 1994-01-11 Johnson Alan J Antihemophilic factor stabilization
AU7254894A (en) * 1993-07-23 1995-02-20 Baxter International Inc. Activated human factor viii and method of preparation
US5576291A (en) * 1993-09-13 1996-11-19 Baxter International Inc. Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4397841A (en) * 1982-06-28 1983-08-09 Monsanto Company Production of blood coagulation factor VIII:C
DK525384D0 (da) * 1984-11-05 1984-11-05 Nordisk Insulinlab Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat

Also Published As

Publication number Publication date
NO167627B (no) 1991-08-19
JPH0535159B2 (es) 1993-05-25
SG14992G (en) 1992-04-16
US4508709A (en) 1985-04-02
AU569129B2 (en) 1988-01-21
JPS60136518A (ja) 1985-07-20
DK575184D0 (da) 1984-12-04
IL73734A0 (en) 1985-03-31
NO844837L (no) 1985-06-06
AU3598284A (en) 1985-06-13
ES538912A0 (es) 1985-11-01
IL73734A (en) 1989-09-28
CA1248449A (en) 1989-01-10
DK575184A (da) 1985-06-06
FI844804L (fi) 1985-06-06
NZ210427A (en) 1988-09-29
EP0144957A2 (en) 1985-06-19
ZA849434B (en) 1985-07-31
FI844804A0 (fi) 1984-12-05
MX7552E (es) 1989-09-25
EP0144957B1 (en) 1991-02-27
DK162896B (da) 1991-12-23
IE843105L (en) 1985-06-05
EP0144957A3 (en) 1987-09-30
ATE60996T1 (de) 1991-03-15
DE3484179D1 (de) 1991-04-04
IE57644B1 (en) 1993-02-10
KR850004593A (ko) 1985-07-25
IN162586B (es) 1988-06-11
NO167627C (no) 1991-11-27
DK162896C (da) 1992-05-11

Similar Documents

Publication Publication Date Title
ES8600690A1 (es) Procedimiento de purificar factores antihemofilicos y similares
DE3467751D1 (en) Process for the treatment of glycerine by distillation
MY108512A (en) Method of purifying protein
JPS5791194A (en) Purification of xanthan gum by enzyme
DE3472218D1 (en) Treatment process for commercial pellets to improve gas separation kinetics
GB2015531B (en) Purification of bordetella proteins by chromatography
AU574133B2 (en) Concentration and purification of hydrogen gas by adsorption process
EP0209786A3 (en) Process for purifying human tumour necrosis factor
HK57092A (en) Treatment of high protein oedemas by direct application of benzo-pyrones
HUT38369A (en) Process for production of 1-methil-4,5-dihydro-aritil-hyntidil-florin amid
EP0185249A3 (en) Process for the purification of crude beta-phenylethyl alcohol
ES8503955A1 (es) Procedimiento para separar y purificar interferon por cromatografia
GB8427232D0 (en) Adsorbents for purification of water &c
JPS5420191A (en) Purification of urokinase
GB2158112B (en) Treatment process for utilization of rubber wood
AU1383483A (en) Catalytic process for conversion of hydrogen chloride to chlorine
AU570511B2 (en) Decomposing n-oxide derivatives to olefine
DE3664757D1 (en) Process for the production of dienes by the dehydration of aldehydes
PH19331A (en) Use of avilamysin to control swine dysenterly
BG30650A1 (en) Method for purifying of splenitis fksonukleaza
FR2544319B1 (fr) Procede de preparation de l'anhydrovinblastine
JPS53145982A (en) Purification of urokinase
YU90084A (en) Process for obtaining adsorbent for effective hydrogen purifying from trace of animal vapours
HUT46302A (en) Process for producing 6,9-phenylamino-analogues of prostacyclin
RO89256A2 (ro) Procedeu de preparare a clorurii de p-clorbenzhidril