ES8507539A1 - Proceso para producir indolcarboxilato de benzoil - Google Patents
Proceso para producir indolcarboxilato de benzoilInfo
- Publication number
- ES8507539A1 ES8507539A1 ES532550A ES532550A ES8507539A1 ES 8507539 A1 ES8507539 A1 ES 8507539A1 ES 532550 A ES532550 A ES 532550A ES 532550 A ES532550 A ES 532550A ES 8507539 A1 ES8507539 A1 ES 8507539A1
- Authority
- ES
- Spain
- Prior art keywords
- benzoyl
- indolecarboxylates
- hydrogen
- lower alkyl
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OUAABOKAKZJGLS-UHFFFAOYSA-N benzoyl 1h-indole-2-carboxylate Chemical class C=1C2=CC=CC=C2NC=1C(=O)OC(=O)C1=CC=CC=C1 OUAABOKAKZJGLS-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003541 chymotrypsin inhibitor Substances 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PRODUCIR INDOLCARBOXILATO DE BENZOIL.COMPRENDE: HACER REACCIONAR UN FENOL SUSTITUIDO 4 DE FORMULA (II), CON UN ACIDO INDOLCARBOXILICO DE FORMULA (III) O UN DERIVADO REACTIVO, PARA OBTENER INDOLCARBOXILATO DE BENZOIL, DE FORMULA (I), EN DONDE R1 ES H, HALOGENO, ALQUILO INFERIOR U OTROS; R2 ES H, UN GRUPO ALQUILO, ACETILO U OTROS, R3 ES H O UN GRUPO ALQUILO INFERIOR, Y A ES UN ENLACE DIRECTO, O UN GRUPO ALQUILENO O VIRILENO SUSTITUIDO EN LA POSICION 2, 3 O 5 DEL NUCLEO INDOL.SE UTILIZAN COMO INHIBITORIOS SOBRE LA QUIMOTRIPSINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58087899A JPS59212471A (ja) | 1983-05-19 | 1983-05-19 | インド−ルカルボン酸ベンゾイルエステル |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES532550A0 ES532550A0 (es) | 1985-10-01 |
| ES8507539A1 true ES8507539A1 (es) | 1985-10-01 |
Family
ID=13927739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532550A Expired ES8507539A1 (es) | 1983-05-19 | 1984-05-17 | Proceso para producir indolcarboxilato de benzoil |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4605739A (es) |
| EP (1) | EP0126598A1 (es) |
| JP (1) | JPS59212471A (es) |
| CA (1) | CA1217183A (es) |
| ES (1) | ES8507539A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010112673A (ko) * | 2000-06-09 | 2001-12-21 | 김환기 | 트로피세트론 염산염(일반식ⅰ)의 제조방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1544673A (fr) * | 1967-05-26 | 1968-11-08 | Esters indolylacétylsalicyliques | |
| FR2244518A1 (en) * | 1973-08-10 | 1975-04-18 | Delalande Sa | N-sinapyl-N'-alkoxyalkyl or-aminocarbonylmethyl-piperazines - as vasodilators, diuretics, antihypertensive and antiulcer agents |
| FR2240734A1 (en) * | 1973-08-13 | 1975-03-14 | Delalande Sa | N-(dihydro sinapyl) piperazine derivs - having antiulcer, hypertensive and diuretic props |
| JPS57203060A (en) * | 1981-06-05 | 1982-12-13 | Kowa Co | Piperazine derivative |
| AU545463B2 (en) * | 1982-06-25 | 1985-07-18 | Kowa Co. Ltd. | Benzoyl piperacine esters |
-
1983
- 1983-05-19 JP JP58087899A patent/JPS59212471A/ja active Pending
-
1984
- 1984-05-10 US US06/608,957 patent/US4605739A/en not_active Expired - Fee Related
- 1984-05-11 EP EP84303197A patent/EP0126598A1/en not_active Withdrawn
- 1984-05-17 ES ES532550A patent/ES8507539A1/es not_active Expired
- 1984-05-17 CA CA000454532A patent/CA1217183A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0126598A1 (en) | 1984-11-28 |
| CA1217183A (en) | 1987-01-27 |
| ES532550A0 (es) | 1985-10-01 |
| US4605739A (en) | 1986-08-12 |
| JPS59212471A (ja) | 1984-12-01 |
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