ES8507473A1 - Un procedimiento para preparar un peptido de resina - Google Patents

Un procedimiento para preparar un peptido de resina

Info

Publication number
ES8507473A1
ES8507473A1 ES532051A ES532051A ES8507473A1 ES 8507473 A1 ES8507473 A1 ES 8507473A1 ES 532051 A ES532051 A ES 532051A ES 532051 A ES532051 A ES 532051A ES 8507473 A1 ES8507473 A1 ES 8507473A1
Authority
ES
Spain
Prior art keywords
peptides
calcitonin
glycine
disclosed
biological activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532051A
Other languages
English (en)
Other versions
ES532051A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Armour Pharmaceutical Co
Original Assignee
Armour Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armour Pharmaceutical Co filed Critical Armour Pharmaceutical Co
Publication of ES532051A0 publication Critical patent/ES532051A0/es
Publication of ES8507473A1 publication Critical patent/ES8507473A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/857—Fish; fish eggs; shell fish; crustacea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN PEPTIDO DE RESINA DE FORMULA (I), EN LA QUE X3 Y X4 PUEDEN SER VARIAS SECUENCIAS DE AMINOACIDOS; R ES LA PORCION POLIESTIRENO Y R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES.COMPRENDE LA UNION DE UN AMINOACIDO PRO, QUE TIENE UN GRUPO PROTECTOR EN LA POSICION BAB-AMINO, A UNA RESINA DE BENZHIDRILAMINA DE FORMULA (II); ELIMINAR EL GRUPO PROTECTOR DE LA POSICION BAB-AMINO DEL -PRO; SELECCIONAR UN AMINOACIDO ADECUADO Y DOTARLE DE UN GRUPO PROTECTOR EN LA POSICION BAB-AMINO; UNIR ESTE AMINOACIDO AL MAS RECIENTEMENTE UNIDO AL PEPTIDO DE RESINA; Y RETIRAR EL GRUPO PROTECTOR DE LA POSICION BAB-AMINO DEL AMINOACIDO SELECCIONADO.ESTOS PEPTIDOS TIENEN APLICACIONES PARA LA PREPARACION DE CALCITONINAS BIOLOGICAMENTE ACTIVAS.
ES532051A 1982-02-12 1984-04-30 Un procedimiento para preparar un peptido de resina Expired ES8507473A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/348,472 US4401593A (en) 1982-02-12 1982-02-12 Glycine - 8 calcitonin

Publications (2)

Publication Number Publication Date
ES532051A0 ES532051A0 (es) 1985-09-01
ES8507473A1 true ES8507473A1 (es) 1985-09-01

Family

ID=23368200

Family Applications (2)

Application Number Title Priority Date Filing Date
ES519735A Expired ES8500218A1 (es) 1982-02-12 1983-02-11 Un procedimiento para preparar peptidos sinteticos del tipo de las calcitoninas.
ES532051A Expired ES8507473A1 (es) 1982-02-12 1984-04-30 Un procedimiento para preparar un peptido de resina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES519735A Expired ES8500218A1 (es) 1982-02-12 1983-02-11 Un procedimiento para preparar peptidos sinteticos del tipo de las calcitoninas.

Country Status (5)

Country Link
US (1) US4401593A (es)
ES (2) ES8500218A1 (es)
FR (1) FR2521553B1 (es)
GB (1) GB2116564B (es)
IT (1) IT1205626B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444681A (en) * 1982-09-24 1984-04-24 Armour Pharmaceutical Company L-Tyrosine21 calcitonin
US4451395A (en) * 1982-11-08 1984-05-29 Armour Pharmaceutical Company Des-serine2 -des-tyrosine22 calcitonin
US4495097A (en) * 1983-04-04 1985-01-22 Armour Pharmaceutical Company Des-serine2 -glycine8 calcitonin
US4497731A (en) * 1983-04-04 1985-02-05 Armour Pharmaceutical Company Glycine 8-des-tyrosine 22 calcitonin
US4663309A (en) * 1983-06-29 1987-05-05 University Patents, Inc. Novel peptide hormones with calcitonin-like activity
US4597900A (en) * 1983-08-22 1986-07-01 Armour Pharmaceutical Co. Des2 -glycine8 -des22 -calcitonin
US4606856A (en) * 1985-03-18 1986-08-19 Seyler Jay K [Des-1-amino, 8-glycine]calcitonin
US5656723A (en) * 1985-12-24 1997-08-12 Milhaud; Gerard Analogues of hypocalcemiant polypeptide compounds sparing the calcium of the organism, their preparation, their use as medicaments and the compositions containing them
FR2592049B1 (fr) * 1985-12-24 1988-02-12 Milhaud Gerard Nouveaux analogues de composes polypeptidiques hypocalcemiants epargnant le calcium de l'organisme, leur preparation et les medicaments contenant ces principes actifs
US4732969A (en) * 1986-05-05 1988-03-22 Armour Pharmaceutical Corporation Des-19-leucine, 20-glutamine-calcitonin
US4746728A (en) * 1986-05-05 1988-05-24 Armour Pharmaceutical Company 8-glycine, des-19-leucine-calcitonin
US5364840A (en) * 1989-12-05 1994-11-15 Vical, Inc. Synthetic calcitonin peptides
US5962270A (en) 1996-02-06 1999-10-05 Bionebraska, Inc. Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs
BRPI0507594A (pt) * 2004-02-11 2007-07-03 Amylin Pharmaceuticals Inc polipetìdeos hìbridos com propriedades selecionáveis
US8076288B2 (en) 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
BRPI0606992A2 (pt) * 2005-02-11 2009-07-28 Amylin Pharmaceuticals Inc análogo e polipeptìdeos hìbridos de gip com propriedades selecionáveis
US8263545B2 (en) * 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
KR101383493B1 (ko) 2005-03-31 2014-04-11 아스트라제네카 파마수티컬스 엘피 정신의학적 질환 및 장애를 치료하기 위한 아밀린 및아밀린 효능제
BRPI0614649A2 (pt) 2005-08-11 2011-04-12 Amylin Pharmaceuticals Inc polipeptìdeos hìbridos com propriedades selecionáveis
EP2330124B1 (en) 2005-08-11 2015-02-25 Amylin Pharmaceuticals, LLC Hybrid polypeptides with selectable properties
US8497240B2 (en) 2006-08-17 2013-07-30 Amylin Pharmaceuticals, Llc DPP-IV resistant GIP hybrid polypeptides with selectable properties

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1950711A1 (de) * 1968-10-15 1970-04-30 Ciba Geigy Neue Peptide und Verfahren zu ihrer Herstellung
JPS5716977B2 (es) * 1972-12-07 1982-04-08
AR207116A1 (es) * 1973-03-28 1976-09-15 Ciba Geigy Ag Procedimiento para preparar nuevas dotriacontapeptidoamidas
US3926938A (en) * 1974-08-12 1975-12-16 Armour Pharma Synthesis of salmon calcitonin
US3929758A (en) * 1974-09-12 1975-12-30 Armour Pharma Cyclization of cysteine-containing peptides
US4217268A (en) * 1978-07-20 1980-08-12 Hughes John L Synthesis of peptides

Also Published As

Publication number Publication date
GB2116564A (en) 1983-09-28
GB2116564B (en) 1985-05-01
ES519735A0 (es) 1984-10-01
IT8319551A0 (it) 1983-02-11
IT1205626B (it) 1989-03-23
US4401593A (en) 1983-08-30
FR2521553B1 (fr) 1986-08-22
ES532051A0 (es) 1985-09-01
GB8303369D0 (en) 1983-03-16
ES8500218A1 (es) 1984-10-01
FR2521553A1 (fr) 1983-08-19

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