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Compania Espanola de Sintesis Quimica SA CESQUISA
Original Assignee
Compania Espanola de Sintesis Quimica SA CESQUISA
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Filing date
Publication date
Application filed by Compania Espanola de Sintesis Quimica SA CESQUISAfiledCriticalCompania Espanola de Sintesis Quimica SA CESQUISA
Priority to ES538539ApriorityCriticalpatent/ES8507155A3/en
Publication of ES538539A0publicationCriticalpatent/ES538539A0/en
Publication of ES8507155A3publicationCriticalpatent/ES8507155A3/en
Steroids of formula (I), in which Y is hydrogen or halogen and Z is hydrogen, halogen or lower alkyl, are made by (a) ortho-esterification of a steroid of formula (II) to form a cpd. of formula (III), in which R and R' are 1-6C alkyl; (b) hydrolysis to a 17alpha-ester; (c) esterification to a 12alpha, 21-diester in which the new acyl gp. is 2-7C; (d) elimination of the 17alpha-acyloxy gp.; (e) selective oxidn. of the Delta16-21 ester formed; and (f) hydrolysis or alcoholysis of the 16alpha, 17alpha-dihydroxy 21-ester obtained.
ES538539A1984-12-121984-12-12Steroid(s) of prednisolone series
ExpiredES8507155A3
(en)
Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids
Stereospecific or stereoselective manufacture of imidazolylloxime ether derivative and imidazolylloxime derivative and imidazolylloxime ether derivative made thereby