RS20060416A - Substituted 16-ketosteroids of the estratriene and androstene series with biological activity - Google Patents

Substituted 16-ketosteroids of the estratriene and androstene series with biological activity

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Publication number
RS20060416A
RS20060416A YUP-2006/0416A YUP20060416A RS20060416A RS 20060416 A RS20060416 A RS 20060416A YU P20060416 A YUP20060416 A YU P20060416A RS 20060416 A RS20060416 A RS 20060416A
Authority
RS
Serbia
Prior art keywords
substituted
radical
estratriene
keto
group
Prior art date
Application number
YUP-2006/0416A
Other languages
Serbian (sr)
Inventor
Ljubica Medić-Mijačević
Vjera Pejanović
Dušan Miljković
Gaši Katarina Penov
Julijana Petrović
Evgenija Đurendić
Radmila Kovačević
Slobodanka Stanković
Original Assignee
Galenika A.D.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galenika A.D., filed Critical Galenika A.D.,
Priority to YUP-2006/0416A priority Critical patent/RS49915B/en
Publication of RS20060416A publication Critical patent/RS20060416A/en
Publication of RS49915B publication Critical patent/RS49915B/en

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Abstract

Invention relates to new, biologically active substituted 16-ketosteroids estratriene and androstene series having the general formula IWherein R is methyl or benzyl radical, and X has the structure as the following Where the R2 hydrogen, alkyl radical from with 1 – 4 carbons, acyl radical, alkylsulphonyloxy radical or aryl radical. According to the invention, onto a 17-keto group of the appropriate 17-keto-16-oxymes is carried out additon of RLi or RMgJ where R has previously mentioned meanings, in tetrehydrofuran where obtained 16-oxymino-17-substituted estratriene and androstene derivative having the general formula as the II that can be separated or further thereto applied is acid hydro titanium thrichloride, where there comes to hydrolysis of 16-oximino group in the appropriate 16-keto group with simultaneous migration of R group with 17α to 17β position when obtained is 16-keto-17 substituted derivative in both series.
YUP-2006/0416A 1996-11-14 1996-11-14 Substituted 16-ketosteroids of the estratriene and androstene series RS49915B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YUP-2006/0416A RS49915B (en) 1996-11-14 1996-11-14 Substituted 16-ketosteroids of the estratriene and androstene series

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YUP-2006/0416A RS49915B (en) 1996-11-14 1996-11-14 Substituted 16-ketosteroids of the estratriene and androstene series

Publications (2)

Publication Number Publication Date
RS20060416A true RS20060416A (en) 2007-04-10
RS49915B RS49915B (en) 2008-09-29

Family

ID=47827550

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2006/0416A RS49915B (en) 1996-11-14 1996-11-14 Substituted 16-ketosteroids of the estratriene and androstene series

Country Status (1)

Country Link
RS (1) RS49915B (en)

Also Published As

Publication number Publication date
RS49915B (en) 2008-09-29

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