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Application filed by Galenika A.D.,filedCriticalGalenika A.D.,
Priority to YUP-2006/0416ApriorityCriticalpatent/RS49915B/en
Publication of RS20060416ApublicationCriticalpatent/RS20060416A/en
Publication of RS49915BpublicationCriticalpatent/RS49915B/en
Invention relates to new, biologically active substituted 16-ketosteroids estratriene and androstene series having the general formula IWherein R is methyl or benzyl radical, and X has the structure as the following Where the R2 hydrogen, alkyl radical from with 1 – 4 carbons, acyl radical, alkylsulphonyloxy radical or aryl radical. According to the invention, onto a 17-keto group of the appropriate 17-keto-16-oxymes is carried out additon of RLi or RMgJ where R has previously mentioned meanings, in tetrehydrofuran where obtained 16-oxymino-17-substituted estratriene and androstene derivative having the general formula as the II that can be separated or further thereto applied is acid hydro titanium thrichloride, where there comes to hydrolysis of 16-oximino group in the appropriate 16-keto group with simultaneous migration of R group with 17α to 17β position when obtained is 16-keto-17 substituted derivative in both series.
YUP-2006/0416A1996-11-141996-11-14Substituted 16-ketosteroids of the estratriene and androstene series
RS49915B
(en)