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Fordonal SA
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Fordonal SA
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Priority to ES537424ApriorityCriticalpatent/ES8507113A1/es
Publication of ES537424A0publicationCriticalpatent/ES537424A0/es
Publication of ES8507113A1publicationCriticalpatent/ES8507113A1/es
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 1,4-DIHIDROPIRIDINAS.COMPRENDE: A) CONDENSAR UN ALDEHIDO DE FORMULA (II) CON UN ACETOACETATO DE ALQUILO DE FORMULA (III) Y CON EL 3-AMINOCROTONITRILO DE FORMULA (IV), EN TETRAHIDROFURANO, DIOXANO O TOLUENO, A UNA TEMPERATURA ENTRE 15 Y 110JC Y SEPARAR EL DISOLVENTE POR DESTILACION A VACIO, PARA OBTENER UN COMPUESTO DE FORMULA (V) Y B) HACER REACCIONAR A (V) CON METANOL, EN PRESENCIA DE ACIDO P-TOLUENSULFONICO, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO (R) UN GRUPO ALQUILO INFERIOR DE C 6.SE UTILIZAN EN CASOS DE HIPERTENSION Y EN TRASTORNOS VASCULARES CEREBRALES.
ES537424A1984-11-071984-11-07Procedimiento para la preparacion de derivados de 1, 4-dihidropiridinas
ExpiredES8507113A1
(es)
6,6-etylen-15,16-metylen-3-oxo-17 -pregn-4-en-21,17-karbolaktoner, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska preparat.