ES8506623A1 - Procedimiento de obtencion de nuevos derivados isoindolicos dicarboxilicos sustituidos. - Google Patents

Procedimiento de obtencion de nuevos derivados isoindolicos dicarboxilicos sustituidos.

Info

Publication number
ES8506623A1
ES8506623A1 ES533174A ES533174A ES8506623A1 ES 8506623 A1 ES8506623 A1 ES 8506623A1 ES 533174 A ES533174 A ES 533174A ES 533174 A ES533174 A ES 533174A ES 8506623 A1 ES8506623 A1 ES 8506623A1
Authority
ES
Spain
Prior art keywords
carbon atoms
formula
alkyl radical
see diagramm
compatible mineral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533174A
Other languages
English (en)
Other versions
ES533174A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES533174A0 publication Critical patent/ES533174A0/es
Publication of ES8506623A1 publication Critical patent/ES8506623A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE FORMULA GENERAL (I) EN LA QUE A REPRESENTA UN CICLO SATURADO O UN GRUPO BENCENICO; R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO INFERIOR DE 1 A 4 ATOMOS DE CARBONO; Y RK REPRESENTA UN RADICAL ALQUILO LINEAL DE 1 A 6 ATOMOS DE CARBONO Y DE SUS FORMAS RACEMICAS Y DE SUS SALES, FARMACEUTICAMENTE COMPATIBLES.CONSISTE EN REALIZAR LA CONDENSACION DE UN DERIVADO DE CARBOXIISOINDOL DE FORMULA GENERAL (II), CON UN DERIVADO FUNCIONAL DE UN AMINO-ACIDO SUSTITUIDO DE FORMULA GENERAL (III).DE APLICACION EN FARMACIA POR SU ACTIVIDAD INHIBIDORA SOBRE CIERTAS ENZIMAS.
ES533174A 1983-06-06 1984-06-06 Procedimiento de obtencion de nuevos derivados isoindolicos dicarboxilicos sustituidos. Expired ES8506623A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8309326A FR2546886B2 (fr) 1983-06-06 1983-06-06 Derives d'acides isoindoledicarboxyliques, leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
ES533174A0 ES533174A0 (es) 1985-08-01
ES8506623A1 true ES8506623A1 (es) 1985-08-01

Family

ID=9289500

Family Applications (1)

Application Number Title Priority Date Filing Date
ES533174A Expired ES8506623A1 (es) 1983-06-06 1984-06-06 Procedimiento de obtencion de nuevos derivados isoindolicos dicarboxilicos sustituidos.

Country Status (13)

Country Link
EP (1) EP0129461B1 (es)
JP (1) JPS6011467A (es)
AT (1) ATE25258T1 (es)
AU (1) AU566490B2 (es)
CA (1) CA1274347A (es)
DE (1) DE3462261D1 (es)
ES (1) ES8506623A1 (es)
FR (1) FR2546886B2 (es)
IE (1) IE57600B1 (es)
NZ (1) NZ208386A (es)
OA (1) OA07716A (es)
PT (1) PT78697A (es)
ZA (1) ZA844262B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1244041A (en) * 1984-07-30 1988-11-01 Elijah H. Gold Process for the preparation of cis, endo- octahydrocyclopenta¬b|pyrrole-2-carboxylate
DE3640641A1 (de) * 1986-11-28 1988-07-14 Thomae Gmbh Dr K Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
DK1603558T3 (da) 2003-02-28 2008-09-01 Servier S A Lab Fremgangsmåde til fremstilling af perindopril og salte deraf

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
EP0046953B1 (de) * 1980-08-30 1989-12-06 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
EP0050800B2 (en) * 1980-10-23 1995-06-07 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
JPS57158758A (en) * 1981-02-17 1982-09-30 Warner Lambert Co Substatuted acyl derivative of octahydro-1h- isoindole-1-carboxylic acid
DE3276311D1 (en) * 1981-02-17 1987-06-19 Warner Lambert Co Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
EP0081094A1 (en) * 1981-11-12 1983-06-15 Merck & Co. Inc. Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
US4431644A (en) * 1982-03-08 1984-02-14 Schering Corporation Antihypertensive agents
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern

Also Published As

Publication number Publication date
EP0129461A1 (fr) 1984-12-27
FR2546886B2 (fr) 1986-05-16
EP0129461B1 (fr) 1987-01-28
ES533174A0 (es) 1985-08-01
ATE25258T1 (de) 1987-02-15
JPS6011467A (ja) 1985-01-21
AU566490B2 (en) 1987-10-22
IE57600B1 (en) 1993-01-27
OA07716A (fr) 1985-08-30
AU2915184A (en) 1984-12-20
IE841386L (en) 1984-12-06
NZ208386A (en) 1989-01-27
FR2546886A2 (fr) 1984-12-07
DE3462261D1 (en) 1987-03-05
ZA844262B (en) 1985-01-30
PT78697A (fr) 1984-07-01
CA1274347A (fr) 1990-09-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001