ES8504167A1 - Un procedimiento para la preparacion de nuevos derivados de 6h-dibenzo (b-e) (1,4) oxatiepina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 6h-dibenzo (b-e) (1,4) oxatiepina.

Info

Publication number
ES8504167A1
ES8504167A1 ES526069A ES526069A ES8504167A1 ES 8504167 A1 ES8504167 A1 ES 8504167A1 ES 526069 A ES526069 A ES 526069A ES 526069 A ES526069 A ES 526069A ES 8504167 A1 ES8504167 A1 ES 8504167A1
Authority
ES
Spain
Prior art keywords
oxathiepin
dibenz
derivatives
residue
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526069A
Other languages
English (en)
Other versions
ES526069A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Publication of ES526069A0 publication Critical patent/ES526069A0/es
Publication of ES8504167A1 publication Critical patent/ES8504167A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE 6H-DIBENZOB,E1,4OXATIEPINA.CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA (III) O SU ISOMERO DE FORMULA (IV) CON UN HIDRURO DE ALUMINIO Y UN METAL ALCALINO, UN BOROHIDRURO DE METAL ALCALINO O CON DIBORANO, PARA CONVERTIR EL SUSTITUYENTE -COOH EN UN GRUPO HIDROXIMETILO Y OBTENER EL COMPUESTO DE FORMULA (I) O SU ISOMERO DE FORMULA (II). DONDE: R, R Y R SE SELECCIONAN INDEPENDIENTEMENTE ENTRE H, HALOGENO, ALQUILO C 1 A 4, ALQUILTIO C 1 A 4, ALQUILSULFONILO DE C 1 A 4 Y OTROS; R ES H, ACILO C 1 A 4 (ALQUIL C 1 A 4) AMINOACETILO, (ALQUIL C 1 A 4) CARBOXI Y OTROS; Z ES TIO, SULFINILO O SULFONILO Y N ES UN NUMERO DE 1 A 4.SE UTILIZAN PARA EL TRATAMIENTO Y CONTROL DEL ASMA ALERGICO.
ES526069A 1982-09-30 1983-09-29 Un procedimiento para la preparacion de nuevos derivados de 6h-dibenzo (b-e) (1,4) oxatiepina. Expired ES8504167A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42957782A 1982-09-30 1982-09-30

Publications (2)

Publication Number Publication Date
ES526069A0 ES526069A0 (es) 1985-04-16
ES8504167A1 true ES8504167A1 (es) 1985-04-16

Family

ID=23703831

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526069A Expired ES8504167A1 (es) 1982-09-30 1983-09-29 Un procedimiento para la preparacion de nuevos derivados de 6h-dibenzo (b-e) (1,4) oxatiepina.

Country Status (7)

Country Link
EP (1) EP0105692B1 (es)
JP (1) JPS5982383A (es)
AT (1) ATE35262T1 (es)
CA (1) CA1208653A (es)
DE (1) DE3377129D1 (es)
DK (1) DK446183A (es)
ES (1) ES8504167A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0157963B1 (en) * 1984-03-28 1989-06-21 Merck & Co. Inc. 6h-dibenz (b,e)(1,4)oxathiepin compounds
US4558037A (en) * 1984-06-04 1985-12-10 Merck & Co., Inc. Cardiovascular composition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480283A1 (fr) * 1980-04-10 1981-10-16 Science Union & Cie Nouveaux derives tricycliques, leurs procedes de preparation et leur utilisation comme medicament

Also Published As

Publication number Publication date
ES526069A0 (es) 1985-04-16
JPS5982383A (ja) 1984-05-12
DK446183D0 (da) 1983-09-29
CA1208653A (en) 1986-07-29
DK446183A (da) 1984-03-31
EP0105692B1 (en) 1988-06-22
ATE35262T1 (de) 1988-07-15
EP0105692A1 (en) 1984-04-18
DE3377129D1 (en) 1988-07-28

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