ES8504167A1 - Un procedimiento para la preparacion de nuevos derivados de 6h-dibenzo (b-e) (1,4) oxatiepina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de 6h-dibenzo (b-e) (1,4) oxatiepina.Info
- Publication number
- ES8504167A1 ES8504167A1 ES526069A ES526069A ES8504167A1 ES 8504167 A1 ES8504167 A1 ES 8504167A1 ES 526069 A ES526069 A ES 526069A ES 526069 A ES526069 A ES 526069A ES 8504167 A1 ES8504167 A1 ES 8504167A1
- Authority
- ES
- Spain
- Prior art keywords
- oxathiepin
- dibenz
- derivatives
- residue
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE 6H-DIBENZOB,E1,4OXATIEPINA.CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA (III) O SU ISOMERO DE FORMULA (IV) CON UN HIDRURO DE ALUMINIO Y UN METAL ALCALINO, UN BOROHIDRURO DE METAL ALCALINO O CON DIBORANO, PARA CONVERTIR EL SUSTITUYENTE -COOH EN UN GRUPO HIDROXIMETILO Y OBTENER EL COMPUESTO DE FORMULA (I) O SU ISOMERO DE FORMULA (II). DONDE: R, R Y R SE SELECCIONAN INDEPENDIENTEMENTE ENTRE H, HALOGENO, ALQUILO C 1 A 4, ALQUILTIO C 1 A 4, ALQUILSULFONILO DE C 1 A 4 Y OTROS; R ES H, ACILO C 1 A 4 (ALQUIL C 1 A 4) AMINOACETILO, (ALQUIL C 1 A 4) CARBOXI Y OTROS; Z ES TIO, SULFINILO O SULFONILO Y N ES UN NUMERO DE 1 A 4.SE UTILIZAN PARA EL TRATAMIENTO Y CONTROL DEL ASMA ALERGICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42957782A | 1982-09-30 | 1982-09-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES526069A0 ES526069A0 (es) | 1985-04-16 |
ES8504167A1 true ES8504167A1 (es) | 1985-04-16 |
Family
ID=23703831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES526069A Expired ES8504167A1 (es) | 1982-09-30 | 1983-09-29 | Un procedimiento para la preparacion de nuevos derivados de 6h-dibenzo (b-e) (1,4) oxatiepina. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0105692B1 (es) |
JP (1) | JPS5982383A (es) |
AT (1) | ATE35262T1 (es) |
CA (1) | CA1208653A (es) |
DE (1) | DE3377129D1 (es) |
DK (1) | DK446183A (es) |
ES (1) | ES8504167A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0157963B1 (en) * | 1984-03-28 | 1989-06-21 | Merck & Co. Inc. | 6h-dibenz (b,e)(1,4)oxathiepin compounds |
US4558037A (en) * | 1984-06-04 | 1985-12-10 | Merck & Co., Inc. | Cardiovascular composition |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2480283A1 (fr) * | 1980-04-10 | 1981-10-16 | Science Union & Cie | Nouveaux derives tricycliques, leurs procedes de preparation et leur utilisation comme medicament |
-
1983
- 1983-09-27 CA CA000437651A patent/CA1208653A/en not_active Expired
- 1983-09-27 DE DE8383305753T patent/DE3377129D1/de not_active Expired
- 1983-09-27 AT AT83305753T patent/ATE35262T1/de not_active IP Right Cessation
- 1983-09-27 EP EP83305753A patent/EP0105692B1/en not_active Expired
- 1983-09-29 ES ES526069A patent/ES8504167A1/es not_active Expired
- 1983-09-29 DK DK446183A patent/DK446183A/da not_active Application Discontinuation
- 1983-09-30 JP JP58180999A patent/JPS5982383A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES526069A0 (es) | 1985-04-16 |
JPS5982383A (ja) | 1984-05-12 |
DK446183D0 (da) | 1983-09-29 |
CA1208653A (en) | 1986-07-29 |
DK446183A (da) | 1984-03-31 |
EP0105692B1 (en) | 1988-06-22 |
ATE35262T1 (de) | 1988-07-15 |
EP0105692A1 (en) | 1984-04-18 |
DE3377129D1 (en) | 1988-07-28 |
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