ES8503642A1 - Procedimiento para la produccion de n-acilo-polipeptidos (como desglose y con prioridad de la patente espanola n 510.167, presentada el 5 de marzo de 1.982). - Google Patents

Procedimiento para la produccion de n-acilo-polipeptidos (como desglose y con prioridad de la patente espanola n 510.167, presentada el 5 de marzo de 1.982).

Info

Publication number
ES8503642A1
ES8503642A1 ES522916A ES522916A ES8503642A1 ES 8503642 A1 ES8503642 A1 ES 8503642A1 ES 522916 A ES522916 A ES 522916A ES 522916 A ES522916 A ES 522916A ES 8503642 A1 ES8503642 A1 ES 8503642A1
Authority
ES
Spain
Prior art keywords
acyl
polypeptides
processes
production
trp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522916A
Other languages
English (en)
Other versions
ES522916A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1531/81A external-priority patent/CH647246A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES522916A0 publication Critical patent/ES522916A0/es
Publication of ES8503642A1 publication Critical patent/ES8503642A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PRODUCCION DE N-ACILO-POLIPEPTIDOS.CONSISTE EN: A) OXIDAR UN N-ACILO-POLIPEPTIDO DE FORMULA (I) DONDE Y1 E Y2 SON H, EN DISOLVENTE, EN PRESENCA DE OXIGENO ATMOSFERICO Y A UNA TEMPERATURA ENTRE C10JC Y 70JC, PARA OBTENER A (I), DONDE Y1 E Y2 FORMAN UN ENLACE DIRECTO; Y B) RECUPERAR A (I) DE LA ETAPA A), EN FORMA LIBRE, DE UN COMPLEJO O DE SAL. SIENDO: ACILO, RESTO ACILO DE UN ACIDO ORGANICO O INORGANICO; A, H O ALQUILO DE C 1 A 3; N-CH(Z)-CO-, UN RESTO (L)- O (D)-FENILAMINA EVENTUALMENTE SUSTITUIDO EN EL ANILLO POR NH2, NO2; Z, EL RESTO RESTANTE DE N-CH-(Z)-CO; B, PHE EVENTUALMENTE SUSTITUIDO EN EL ANILLO POR NH2 O NO2; C, TRP O D-TRP EVENTUALMENTE BAB-N-METILADO; D, LYS EVENTUALMENTE BAB-N-METILADO; E, UN RESTO BAB-AMINOACIDO DE UN D-AMINOACIDO; F UN GRUPO -COOR O -CH2OR2; Y R1 Y R2 SON H.
ES522916A 1981-03-06 1983-06-01 Procedimiento para la produccion de n-acilo-polipeptidos (como desglose y con prioridad de la patente espanola n 510.167, presentada el 5 de marzo de 1.982). Expired ES8503642A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1531/81A CH647246A5 (en) 1981-03-06 1981-03-06 Polypeptide derivatives, their preparation and pharmaceutical products which contain these polypeptide derivatives
CH572381 1981-09-04

Publications (2)

Publication Number Publication Date
ES522916A0 ES522916A0 (es) 1985-03-01
ES8503642A1 true ES8503642A1 (es) 1985-03-01

Family

ID=25687920

Family Applications (2)

Application Number Title Priority Date Filing Date
ES510167A Granted ES510167A0 (es) 1981-03-06 1982-03-05 Procedimiento para la produccion de n-acilo-polipeptidos.
ES522916A Expired ES8503642A1 (es) 1981-03-06 1983-06-01 Procedimiento para la produccion de n-acilo-polipeptidos (como desglose y con prioridad de la patente espanola n 510.167, presentada el 5 de marzo de 1.982).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES510167A Granted ES510167A0 (es) 1981-03-06 1982-03-05 Procedimiento para la produccion de n-acilo-polipeptidos.

Country Status (16)

Country Link
US (1) US4435385A (es)
AU (1) AU8116482A (es)
CA (1) CA1188682A (es)
DE (1) DE3207311A1 (es)
DK (1) DK81082A (es)
ES (2) ES510167A0 (es)
FI (1) FI820689L (es)
FR (1) FR2501199B1 (es)
GB (1) GB2095261B (es)
GR (1) GR78227B (es)
IL (1) IL65167A (es)
IT (1) IT1189229B (es)
NL (1) NL8200828A (es)
NZ (1) NZ199911A (es)
PT (1) PT74526B (es)
SE (1) SE8201339L (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH655505B (es) * 1982-08-24 1986-04-30
CA1249397A (en) * 1984-03-07 1989-01-24 Fadia E. Ali Process for preparing des-proline vasopressin antagonists
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
GB8423431D0 (en) * 1984-09-17 1984-10-24 Sandoz Ltd Organic compounds
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体
GR862206B (en) * 1985-09-12 1986-12-31 Univ Tulane Therapeutic somatostatin analogs
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
US4798821A (en) * 1987-03-02 1989-01-17 Merck & Co., Inc. Antihypertensive therapy for diabetics
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
US5019647A (en) * 1988-05-24 1991-05-28 Merck & Co., Inc. Gastrin releasing peptide antagonist
US5028692A (en) * 1989-04-25 1991-07-02 Merck & Co., Inc. Gastrin releasing peptide antagonist
HUT59166A (en) * 1989-12-08 1992-04-28 Univ Tulane Process for producing octqpeptide somatostatine analogues with treonine at the 6 position and pharmaceutical compositions containing them
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
ATE262921T1 (de) * 1997-05-13 2004-04-15 Sod Conseils Rech Applic Somatostatin und somatostatin agoniste zur behandlung der insulinsunempfindlichkeit und syndrome x
US7026289B2 (en) 1997-05-13 2006-04-11 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Method and compositions for treating hyperlipidemia and other conditions
AU7655098A (en) 1997-05-13 1998-12-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Somatostatin and somatostatin agonists for decreasing body weight
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US6750199B2 (en) * 2000-07-17 2004-06-15 Micrologix Biotech Inc. Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
WO2002100888A1 (en) 2001-06-08 2002-12-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatin-dopamine chimeric analogs
AU2004232314B2 (en) 2003-04-22 2007-11-22 Ipsen Pharma S.A.S. Peptide vectors
CA2918787A1 (en) 2013-06-13 2014-12-18 George Tachas Combination therapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904594A (en) 1973-07-02 1975-09-09 Salk Inst For Biological Studi Somatostatin and acylated des-(ala' 1', gly' 2') derivatives thereof
DE2608336A1 (de) * 1975-03-11 1976-09-30 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
NL7902932A (nl) * 1978-04-24 1979-10-26 American Home Prod Aan somatostatine structureel verwante peptiden.
US4225472A (en) * 1979-05-29 1980-09-30 American Home Products Corporation Truncated somatostatin analogs
DE19375086I2 (de) * 1979-11-27 2003-01-09 Novartis Ag Polypeptide Verfahren zu ihrer Herstellung pharmazeutische Zusammensetzungen die diese Polypeptide enthalten und ihre Verwendung
US4282143A (en) * 1980-06-13 1981-08-04 American Home Products Corporation Octapeptides lowering growth hormone

Also Published As

Publication number Publication date
NL8200828A (nl) 1982-10-01
FR2501199B1 (fr) 1986-02-21
ES8400082A1 (es) 1983-10-16
ES522916A0 (es) 1985-03-01
IT1189229B (it) 1988-01-28
SE8201339L (sv) 1982-09-07
DE3207311A1 (de) 1982-12-02
GB2095261B (en) 1984-08-15
PT74526B (en) 1984-10-09
DK81082A (da) 1982-09-07
PT74526A (en) 1982-04-01
IL65167A0 (en) 1982-05-31
CA1188682A (en) 1985-06-11
IL65167A (en) 1985-06-30
GB2095261A (en) 1982-09-29
IT8247937A0 (it) 1982-03-05
FI820689L (fi) 1982-09-07
ES510167A0 (es) 1983-10-16
NZ199911A (en) 1985-05-31
AU8116482A (en) 1982-09-09
FR2501199A1 (fr) 1982-09-10
US4435385A (en) 1984-03-06
GR78227B (es) 1984-09-26

Similar Documents

Publication Publication Date Title
ES8400082A1 (es) Procedimiento para la produccion de n-acilo-polipeptidos.
ES8606365A1 (es) Un procedimiento para la preparacion de surfactantes de fos-fato
ES521491A0 (es) Metodo de preparar amidoaminoacidos n-substituidos.
DK624884D0 (da) Peptider
IT1119919B (it) Procedimento per l'elettrolisi di una salamoia di cloruro di metallo alcalino
EP0135846A3 (en) Production of l-amino acids by transamination
DE3572345D1 (en) 3-amino-2-benzoyl-acrylic-acid derivatives and process for their preparation
IT7947958A0 (it) Procedimento per la scissione di acido cloridrico da soluzioni di cloridrati amminici
GB2021105B (en) Manufacture of , unsaturated n-substituted carboxylic acid amides
HUT40126A (en) Process for producing 6,7-disubstituted-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtiridine-3-carboxylic acid derivatives and pharmaceutical compositions and food additives containing them
PL286043A1 (en) Method for manufacturing new proteins
ES8304919A1 (es) Un procedimiento para la preparacion de dicloroamino-acidos.
IL65217A (en) N-(2,2,2-trifluoroethyl)-n-alkyl-azolyloxyacetic acid amides,their preparation and their use as herbicides
DE3678053D1 (de) Herstellungsverfahren von trifluoressigsaeurealkylestern.
JPS55115851A (en) Recovery of amino acid from protein hydrolyzate
ES8507098A1 (es) Procedimiento para la preparacion de l(-)carnitina en forma de cloridrato o en forma de su sal interna.
GB2111055B (en) N-(vinblastinoyl-23) derivative of amino acids
ZA792120B (en) Process for the manufacture of ab-unsaturated n-substituted carboxylic acid amides
ES467886A1 (es) Procedimiento para la preparacion de derivados de acido oleanoico.
DE3471938D1 (en) Antibiotics, method for their preparation, their use as medicines and intermediates for their preparation
ES480329A1 (es) Procedimiento para la preparacion de derivados de acidos benzoilfenoxialcanoicos.
GB2039292B (en) Lubricating oil compositions containing salts of amino acids
YU238480A (en) Process for producing an amide chloride of 4-aminobutyric acid
ZA791345B (en) Novel pharmaceutical compositions containing an amino acid derivative
ES2000879A6 (es) Un procedimiento para preparar una sal de acido inorganico de cloruro de n-(1(s)-etoxicarbonil-3-fenilpropil)-l-alanilo