ES8503132A1 - Procedimiento para la determinacion cuantitativa de antitrombina-iii en plasma sanguineo de mamiferos - Google Patents
Procedimiento para la determinacion cuantitativa de antitrombina-iii en plasma sanguineo de mamiferosInfo
- Publication number
- ES8503132A1 ES8503132A1 ES525637A ES525637A ES8503132A1 ES 8503132 A1 ES8503132 A1 ES 8503132A1 ES 525637 A ES525637 A ES 525637A ES 525637 A ES525637 A ES 525637A ES 8503132 A1 ES8503132 A1 ES 8503132A1
- Authority
- ES
- Spain
- Prior art keywords
- iii
- thrombin
- change
- strip
- material containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
- G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
- G03F7/70—Microphotolithographic exposure; Apparatus therefor
- G03F7/70216—Mask projection systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
- G01N33/526—Multi-layer analytical elements the element being adapted for a specific analyte
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8121—Serpins
- G01N2333/8128—Antithrombin III
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PROCEDIMIENTO PARA LA DETERMINACION CUANTITATIVA DE ANTITROMBINA-III EN PLASMA SANGUINEO DE MAMIFEROS.CONSISTE EN: A) PONER EN CONTACTO EL PLASMA CON HEPARINA EN EXCESO Y UNA TIRA REACTIVA DE 3 CAPAS QUE COMPRENDE: UNA PRIMERA CAPA SUPERIOR DE UNA MATRIZ SOPORTE QUE TIENE ABSORBIDA EN LA MISMA TROMBINA Y UN TAMPON; UNA SEGUNDA CAPA INFERIOR DE UNA MATRIZ SOPORTE QUE TIENE UN SUSTRATO FLUOROGENICO O CROMOGENICO SENSIBLE A TROMBINA Y UN TAMPON Y UNA CAPA DE MATERIAL IMPERMEABLE AL AGUA POR DEBAJO DE LA CAPA INFERIOR; B) REGULAR CUALQUIER CAMBIO QUIMICO EN EL SUSTRATO POR MEDIOS ESPECTROFLUOROMETRICOS O ESPECTROFOTOMETRICOS DE REFLECTANCIA; Y C) COMPARAR LA RELACION ENTRE LOS VALORES OBTENIDOS EN LA ETAPA (B) CON LOS VALORES OBTENIDOS DE MANERA SIMILAR EMPLEANDO MUESTRAS DE PLASMA QUE CONTIENEN CANTIDADES CONOCIDAS DE AT-III Y UTILIZAR LA COMPARACION PARA DETERMINAR LA CONCENTRACION DE AT-III DE LA MUESTRA DE PLASMA A ANALIZAR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/418,285 US4473639A (en) | 1982-09-15 | 1982-09-15 | Reagent strip test for antithrombin-III |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8503132A1 true ES8503132A1 (es) | 1985-02-01 |
ES525637A0 ES525637A0 (es) | 1985-02-01 |
Family
ID=23657466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES525637A Granted ES525637A0 (es) | 1982-09-15 | 1983-09-15 | Procedimiento para la determinacion cuantitativa de antitrombina-iii en plasma sanguineo de mamiferos |
Country Status (8)
Country | Link |
---|---|
US (1) | US4473639A (es) |
EP (1) | EP0103247B1 (es) |
JP (1) | JPS59131166A (es) |
AU (1) | AU541754B2 (es) |
CA (1) | CA1187387A (es) |
DE (1) | DE3371364D1 (es) |
ES (1) | ES525637A0 (es) |
IL (1) | IL68674A (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4543335A (en) * | 1982-12-20 | 1985-09-24 | Miles Laboratories, Inc. | Device and method for the quantitative determination of heparin in mammalian blood plasma |
CA1254119A (en) * | 1984-07-20 | 1989-05-16 | Lloyd A. Schick | Single step protease inhibitor assay |
ZA858813B (en) * | 1984-11-19 | 1986-08-27 | Boehringer Mannheim Gmbh | Reagent for blood coagulation tests |
DE3516579A1 (de) * | 1984-11-19 | 1986-05-22 | Boehringer Mannheim Gmbh, 6800 Mannheim | Gerinnungstest auf teststreifen |
DE3616496A1 (de) * | 1986-05-16 | 1987-11-19 | Boehringer Mannheim Gmbh | Analyseelement zur bestimmung von gerinnungsparametern |
US5110727A (en) * | 1987-04-03 | 1992-05-05 | Cardiovascular Diagnostics, Inc. | Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles |
US5320945A (en) * | 1989-07-14 | 1994-06-14 | Boehringer Mannheim Gmbh | Method and reagent for the determination of antithrombin III |
DE3923340A1 (de) * | 1989-07-14 | 1991-01-24 | Boehringer Mannheim Gmbh | Verfahren und reagenz zur bestimmung von antithrombin iii |
ATE121139T1 (de) * | 1990-11-05 | 1995-04-15 | Baxter Diagnostics Inc | Verfahren zur bestimmung der konzentration von antikoagulantien. |
JPH078298A (ja) * | 1993-06-28 | 1995-01-13 | Nippon Shoji Kk | アンチトロンビンiii活性の測定方法および該測定用試薬キット |
JP3927425B2 (ja) * | 1996-11-21 | 2007-06-06 | 積水化学工業株式会社 | 血液凝固促進剤及び血液検査用容器 |
JP3401162B2 (ja) * | 1996-11-21 | 2003-04-28 | 積水化学工業株式会社 | 血液凝固促進剤及び血液検査用容器 |
JP3927403B2 (ja) * | 1996-11-21 | 2007-06-06 | 積水化学工業株式会社 | 血液凝固促進剤及び血液検査用容器 |
US5985582A (en) * | 1997-12-09 | 1999-11-16 | Sigma-Aldrich Co. | Thrombin-based assay for antithrombin III |
GB2426334A (en) | 2005-05-20 | 2006-11-22 | Orion Diagnostica Oy | Application of a reagent to a matrix material |
CN103604766A (zh) * | 2013-11-25 | 2014-02-26 | 牡丹江友搏药业股份有限公司 | 一种疏血通注射液的生物学质控方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4061625A (en) * | 1975-07-11 | 1977-12-06 | Ab Kabi | Novel chromogenic thrombin substrates |
US4247454A (en) * | 1975-07-11 | 1981-01-27 | Ab Kabi | Novel chromogenic thrombin substrates |
DE2812943C3 (de) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma |
US4302538A (en) * | 1978-03-27 | 1981-11-24 | Ortho Diagnostics Inc. | Buffer system in an anti-thrombin III test |
US4275153A (en) * | 1978-08-03 | 1981-06-23 | American Hospital Supply Corporation | Analytical fluorogenic substrates for proteolytic enzymes |
US4221706A (en) * | 1979-06-14 | 1980-09-09 | Abbott Laboratories | Chromogenic substrates |
US4324858A (en) * | 1980-06-16 | 1982-04-13 | Midwest Research Institute | Stabilization of cholinesterase, detector kit using stabilized cholinesterase, and methods of making and using the same |
US4390343A (en) * | 1981-07-06 | 1983-06-28 | Miles Laboratories, Inc. | Multilayer analytical element having an impermeable radiation diffusing and blocking layer |
US4363874A (en) * | 1981-08-07 | 1982-12-14 | Miles Laboratories, Inc. | Multilayer analytical element having an impermeable radiation nondiffusing reflecting layer |
-
1982
- 1982-09-15 US US06/418,285 patent/US4473639A/en not_active Expired - Fee Related
-
1983
- 1983-05-11 CA CA000427912A patent/CA1187387A/en not_active Expired
- 1983-05-12 IL IL68674A patent/IL68674A/xx unknown
- 1983-05-18 AU AU14663/83A patent/AU541754B2/en not_active Ceased
- 1983-09-05 EP EP83108720A patent/EP0103247B1/en not_active Expired
- 1983-09-05 DE DE8383108720T patent/DE3371364D1/de not_active Expired
- 1983-09-14 JP JP58168526A patent/JPS59131166A/ja active Granted
- 1983-09-15 ES ES525637A patent/ES525637A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
JPH0322948B2 (es) | 1991-03-27 |
EP0103247A3 (en) | 1985-10-23 |
EP0103247A2 (en) | 1984-03-21 |
AU541754B2 (en) | 1985-01-17 |
IL68674A (en) | 1986-02-28 |
US4473639A (en) | 1984-09-25 |
ES525637A0 (es) | 1985-02-01 |
EP0103247B1 (en) | 1987-05-06 |
AU1466383A (en) | 1984-03-22 |
JPS59131166A (ja) | 1984-07-27 |
DE3371364D1 (en) | 1987-06-11 |
CA1187387A (en) | 1985-05-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970303 |