ES8407017A1 - Procedimiento para preparar nuevos derivados de w-mercaptopropanamida - Google Patents

Procedimiento para preparar nuevos derivados de w-mercaptopropanamida

Info

Publication number
ES8407017A1
ES8407017A1 ES528764A ES528764A ES8407017A1 ES 8407017 A1 ES8407017 A1 ES 8407017A1 ES 528764 A ES528764 A ES 528764A ES 528764 A ES528764 A ES 528764A ES 8407017 A1 ES8407017 A1 ES 8407017A1
Authority
ES
Spain
Prior art keywords
radical
carbon atoms
formula
radicals
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528764A
Other languages
English (en)
Other versions
ES528764A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES528764A0 publication Critical patent/ES528764A0/es
Publication of ES8407017A1 publication Critical patent/ES8407017A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE W-MERCAPTOTROPANAMIDA.CONSISTE EN LA PREPARACION DE COMPUESTOS DE FORMULA (I) EN LA QUE R1 REPRESENTA UN ATOMO DE HIDROGENO U OTROS; R2 UN ATOMO DE HIDROGENO, UN RADICAL ALQUILO U OTROS; R3 UN RADICAL HETEROCICLICO ESCOGIDO ENTRE LOS RADICALES TIAZOLILO U OTROS. SE SOMETE UN ACIDO DE FORMULA (II) EN LOS QUE R1 Y R2 TIENEN LOS SIGNIFICADOS ANTERIORES, A LA ACCION DE UN ACIDO DE FORMULA H2N-R3, EN LA QUE R3 TIENE EL VALOR ANTERIOR, PARA OBTENER EL COMPUESTO DE FORMULA (I) QUE SE SOMETEN, SI SEDESEA, A LA ACCION DE UNA BASE O DE UN ACIDO PARA FORMAR LA SAL.TIENE PROPIEDADES FARMACOLOGICAS EN EL TRATAMIENTO DE LAS ALGIAS MUSCULARES, ARTICULACIONES O NERVIOSAS Y EN LAS AFECCIONES REUMATICAS.
ES528764A 1983-02-07 1984-01-10 Procedimiento para preparar nuevos derivados de w-mercaptopropanamida Expired ES8407017A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8301862A FR2540495B1 (fr) 1983-02-07 1983-02-07 Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus

Publications (2)

Publication Number Publication Date
ES528764A0 ES528764A0 (es) 1984-08-16
ES8407017A1 true ES8407017A1 (es) 1984-08-16

Family

ID=9285651

Family Applications (1)

Application Number Title Priority Date Filing Date
ES528764A Expired ES8407017A1 (es) 1983-02-07 1984-01-10 Procedimiento para preparar nuevos derivados de w-mercaptopropanamida

Country Status (17)

Country Link
US (1) US5098934A (es)
EP (1) EP0115997B1 (es)
JP (1) JPS59148759A (es)
KR (1) KR910008182B1 (es)
AT (1) ATE28451T1 (es)
AU (1) AU568628B2 (es)
CA (1) CA1244029A (es)
DE (1) DE3464907D1 (es)
DK (1) DK169668B1 (es)
ES (1) ES8407017A1 (es)
FR (1) FR2540495B1 (es)
GR (1) GR81410B (es)
HU (1) HU193552B (es)
IE (2) IE57052B1 (es)
NZ (1) NZ207056A (es)
PT (1) PT78070B (es)
ZA (1) ZA84570B (es)

Families Citing this family (31)

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FR2540498B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux medicaments derives d'amides d'acide mercaptoacetique et de l'acide 3-mercaptopropionique et les compositions pharmaceutiques les renfermant
US4868310A (en) * 1986-08-04 1989-09-19 Rohm And Haas Company Process for preparing isothiazolones
FR2611712B1 (fr) * 1987-02-26 1989-06-23 Roussel Uclaf Nouveaux derives n-substitues de l'alpha-mercaptomethyl benzene propanamide, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
US5179125A (en) * 1987-12-03 1993-01-12 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
US5210266A (en) * 1987-12-03 1993-05-11 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
EP0318859A3 (en) * 1987-12-03 1990-08-16 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
US4970303A (en) * 1988-02-03 1990-11-13 Xoma Corporation Linking agents and methods
US5202340A (en) * 1988-05-06 1993-04-13 Ono Pharmaceutical Co., Ltd. Amino acid derivatives
JPH02209861A (ja) * 1988-05-06 1990-08-21 Ono Pharmaceut Co Ltd アミノ酸誘導体及び該誘導体を有効成分として含有するエンケファリナーゼ阻害剤
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives
EP0361365A1 (en) * 1988-09-30 1990-04-04 E.R. SQUIBB & SONS, INC. Aminobenzoic and aminocyclohexane-carboylic acid compounds, compositions, and their method of use
US5223516A (en) * 1990-03-22 1993-06-29 E. R. Squibb & Sons, Inc. 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same
ATE137744T1 (de) * 1990-11-26 1996-05-15 Taisho Pharmaceutical Co Ltd Anilidderivat
DE59208679D1 (de) * 1991-11-01 1997-08-14 Ciba Geigy Ag Buttersäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfung
GB9123353D0 (en) * 1991-11-04 1991-12-18 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
FR2683817B1 (fr) * 1991-11-18 1994-02-25 Upsa Laboratoires Nouveaux derives d'alpha-amino n-pyridyl benzene propanamide, leurs procedes de preparation, compositions pharmaceutiques les contenant.
FR2687147A1 (fr) * 1992-02-11 1993-08-13 Union Pharma Scient Appl Nouveaux derives d'alpha-amino n-pyridyl benzene propanamide, leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
IT1266571B1 (it) * 1993-07-30 1997-01-09 Zambon Spa Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari
CN1035252C (zh) * 1993-11-23 1997-06-25 王桂英 氨甲基甲酸-1，1，1-三氯-2-(2,4－二氯硫酚基) 乙基酯及其制备方法
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
WO1998041673A1 (fr) * 1997-03-18 1998-09-24 Ceca S.A. Sels de mercaptoacides et d'imidazolines comme inhibiteurs de la corrosion carbonique du fer et des metaux ferreux
US7195284B2 (en) * 2004-07-19 2007-03-27 Snyder Industries, Inc. Flexible synthetic resin coupling
CH706854A2 (de) 2012-08-21 2014-02-28 Dr Rer Nat Lisseth Sandoval Soto Verfahren und Vorrichtung zur Bestimmung der elektrischen Eigenschaften von Materialien.

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US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives

Also Published As

Publication number Publication date
FR2540495A1 (fr) 1984-08-10
KR850001162A (ko) 1985-03-16
DK51384D0 (da) 1984-02-06
IE840278L (en) 1984-08-07
ATE28451T1 (de) 1987-08-15
NZ207056A (en) 1987-09-30
JPS59148759A (ja) 1984-08-25
ES528764A0 (es) 1984-08-16
IE57052B1 (en) 1992-04-08
EP0115997A3 (en) 1985-05-29
EP0115997B1 (fr) 1987-07-22
FR2540495B1 (fr) 1986-02-14
KR910008182B1 (ko) 1991-10-10
IE840279L (en) 1984-08-07
DE3464907D1 (en) 1987-08-27
US5098934A (en) 1992-03-24
IE57391B1 (en) 1992-08-26
PT78070A (fr) 1984-03-01
EP0115997A2 (fr) 1984-08-15
JPH0518823B2 (es) 1993-03-15
PT78070B (fr) 1986-06-11
HU193552B (en) 1987-10-28
CA1244029A (fr) 1988-11-01
DK51384A (da) 1984-08-08
DK169668B1 (da) 1995-01-09
ZA84570B (en) 1985-02-27
AU568628B2 (en) 1988-01-07
AU2420184A (en) 1984-08-16
GR81410B (es) 1984-12-11

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FD1A Patent lapsed

Effective date: 20000201