ES8405759A1 - Procedimiento de produccion del aspartamo por sintesis. - Google Patents
Procedimiento de produccion del aspartamo por sintesis.Info
- Publication number
- ES8405759A1 ES8405759A1 ES521281A ES521281A ES8405759A1 ES 8405759 A1 ES8405759 A1 ES 8405759A1 ES 521281 A ES521281 A ES 521281A ES 521281 A ES521281 A ES 521281A ES 8405759 A1 ES8405759 A1 ES 8405759A1
- Authority
- ES
- Spain
- Prior art keywords
- aspartame
- aspartic acid
- protected
- functional group
- amine functional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 title abstract 4
- 108010011485 Aspartame Proteins 0.000 title abstract 3
- 229960003438 aspartame Drugs 0.000 title abstract 3
- 235000010357 aspartame Nutrition 0.000 title abstract 3
- 239000000605 aspartame Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 4
- 235000003704 aspartic acid Nutrition 0.000 abstract 4
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 4
- 125000003277 amino group Chemical group 0.000 abstract 2
- 150000008064 anhydrides Chemical class 0.000 abstract 2
- 239000002262 Schiff base Substances 0.000 abstract 1
- 150000004753 Schiff bases Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- VSDUZFOSJDMAFZ-VIFPVBQESA-N methyl L-phenylalaninate Chemical compound COC(=O)[C@@H](N)CC1=CC=CC=C1 VSDUZFOSJDMAFZ-VIFPVBQESA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA LA PRODUCCION DEL ASPARTAMO BAJO UNA FORMA DE MEZCLA DE ISOMEROS, DE FORMULA GENERAL (I).CONSISTE EN PROTEGER EL ACIDO ASPARTICO DEL COMIENZO POR MEDIO DE LA PRODUCCION DE UNA BASE DE SCHIFF DEL ACIDO ASPARTICO, LA CUAL SE OBTIENE POR TRATAMIENTO DEL ACIDO ASPARTICO, DE UNA DE SUS SALES ALCALINAS O DE UNA SAL DE ESTE ACIDO, CON UNA AMINA TERCIARIA DE FORMULA GENERAL (II), EN LA QUE R ES UN ATOMO DE HIDROGENO O UN RADICAL ALQUILICO INFERIOR, DE PREFERENCIA UN RADICAL METILO; Y R1 Y R2, INDEPENDIENTEMENTE EL UNO DEL OTRO, SON UN ATOMO DE HIDROGENO,DE HALOGENO O UN GRUPO NITRO.DE APLICACION COMO EDULCORANTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8206066A FR2524877A1 (fr) | 1982-04-07 | 1982-04-07 | Procede nouveau de production de l'aspartame |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES521281A0 ES521281A0 (es) | 1984-06-16 |
| ES8405759A1 true ES8405759A1 (es) | 1984-06-16 |
Family
ID=9272852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES521281A Expired ES8405759A1 (es) | 1982-04-07 | 1983-04-06 | Procedimiento de produccion del aspartamo por sintesis. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0091330A1 (es) |
| BE (1) | BE896362A (es) |
| ES (1) | ES8405759A1 (es) |
| FR (1) | FR2524877A1 (es) |
| IT (1) | IT1194171B (es) |
| LU (1) | LU84733A1 (es) |
| PT (1) | PT76514B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2042417A1 (es) * | 1992-05-18 | 1993-12-01 | Genesis Para La Investigacion | Procedimiento de obtencion de alfa-aspartame. |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT8419324A0 (it) * | 1984-01-26 | 1984-01-26 | Pierrel Spa | Procedimento per la sintesi di derivati n-acilici dell'aspartame. |
| DE69321583T2 (de) * | 1992-12-21 | 1999-06-24 | Ajinomoto Kk | Aminosäurderivat und anti-aktiv-saurstoff-mittel |
| AU768649B2 (en) * | 1998-09-25 | 2003-12-18 | University Of Queensland, The | Auxiliary for amide bond formation |
| AUPP616498A0 (en) | 1998-09-25 | 1998-10-15 | University Of Queensland, The | Synthesis of cyclic peptides |
| AUPP616598A0 (en) * | 1998-09-25 | 1998-10-15 | University Of Queensland, The | Auxiliary for amide bond formation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2078640A5 (en) * | 1970-02-21 | 1971-11-05 | Beecham Group Ltd | Alpha-asparaginyl dipeptides prepn |
-
1982
- 1982-04-07 FR FR8206066A patent/FR2524877A1/fr active Granted
-
1983
- 1983-03-04 EP EP83400447A patent/EP0091330A1/fr not_active Withdrawn
- 1983-03-24 IT IT20259/83A patent/IT1194171B/it active
- 1983-04-01 BE BE6/47806A patent/BE896362A/fr not_active IP Right Cessation
- 1983-04-06 PT PT76514A patent/PT76514B/pt unknown
- 1983-04-06 ES ES521281A patent/ES8405759A1/es not_active Expired
- 1983-04-06 LU LU84733A patent/LU84733A1/fr unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2042417A1 (es) * | 1992-05-18 | 1993-12-01 | Genesis Para La Investigacion | Procedimiento de obtencion de alfa-aspartame. |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2524877A1 (fr) | 1983-10-14 |
| PT76514A (fr) | 1983-05-01 |
| ES521281A0 (es) | 1984-06-16 |
| PT76514B (fr) | 1985-12-10 |
| FR2524877B1 (es) | 1985-03-08 |
| BE896362A (fr) | 1983-10-03 |
| LU84733A1 (fr) | 1983-11-17 |
| EP0091330A1 (fr) | 1983-10-12 |
| IT8320259A0 (it) | 1983-03-24 |
| IT1194171B (it) | 1988-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5214511A (en) | Process for producing a linear additive | |
| ES8405759A1 (es) | Procedimiento de produccion del aspartamo por sintesis. | |
| JPS5223017A (en) | Process for purification of (meth) acrylic acid or its esters | |
| IL63464A (en) | Process for the production of 1,4:3,6-dianhydro-d-glucitol-5-nitrate and pharmaceutical compositions containing the compound produced by said process | |
| JPS51149300A (en) | Process for purifying stevioside | |
| ES8506598A1 (es) | Un procedimiento para la preparacion del ester 1-metilico de la n-l -aspartil-l-fenilalanina (aspartamo) | |
| UY23603A1 (es) | Un proceso para hacer 1-ciclopentilalquil aminas de utilidad para la sintesis de edulcorantes | |
| JPS5239648A (en) | Aprocess for preparing p-cyanobenzoic acid amide from terephthalonitril e | |
| JPS5373507A (en) | Crystallization of pentaerythritol | |
| ATE45727T1 (de) | Verfahren zur herstellung von n-substituierten, alpha, beta-ungesaettigten carbonsaeureamiden. | |
| JPS5735570A (en) | Alpha-amino-beta-hydroxybutyryl-l-hystidine and its preparation | |
| JPS52105141A (en) | Preparation of perfluorononenyloxybenzoic acid | |
| JPS51133249A (en) | A process for preparing alkyl-2,4- dichloro-nitrophenylcarbonates | |
| JPS57120570A (en) | Preparation of 1,3-dialkyl-2-imidazolidinone | |
| JPS55127349A (en) | Simultaneous removal of water and picolines | |
| JPS5395925A (en) | Preparation of p-phenylenediamine | |
| JPS5738756A (en) | Tripeptide alkylamide derivative | |
| JPS5488220A (en) | Preparation of aminonitrile | |
| JPS5217447A (en) | Process for preparation of trans-4- aminomethylcyclohexane-carboxylic acid ester | |
| JPS5223022A (en) | Process for separation of -beta hydroxyvaline | |
| JPS5211193A (en) | Production of crystalline gypsum fiber | |
| JPS5231007A (en) | Synthesis of 3,7-dimethyl-2-octene-1,7- diol | |
| JPS5271445A (en) | Novel method of preparing 3'-4'-dideoxy-kanamycin b | |
| JPS5236660A (en) | Process for purification of adrenochrome.monoaminoguanidine | |
| JPS53127412A (en) | Preparation of glycine ethyl ester hydrochloride |