ES8401009A1 - Procedimiento para la preparacion de 2-(p-isobutil-fenil)propionato de 2-hidroxi-3-(o-metoxi-fenoxi)propilo. - Google Patents

Procedimiento para la preparacion de 2-(p-isobutil-fenil)propionato de 2-hidroxi-3-(o-metoxi-fenoxi)propilo.

Info

Publication number
ES8401009A1
ES8401009A1 ES517685A ES517685A ES8401009A1 ES 8401009 A1 ES8401009 A1 ES 8401009A1 ES 517685 A ES517685 A ES 517685A ES 517685 A ES517685 A ES 517685A ES 8401009 A1 ES8401009 A1 ES 8401009A1
Authority
ES
Spain
Prior art keywords
phenoxy
propionate
isobutyl
methoxy
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517685A
Other languages
English (en)
Other versions
ES517685A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ausonia Farmaceutici SRL
Original Assignee
Ausonia Farmaceutici SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ausonia Farmaceutici SRL filed Critical Ausonia Farmaceutici SRL
Publication of ES8401009A1 publication Critical patent/ES8401009A1/es
Publication of ES517685A0 publication Critical patent/ES517685A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 2-(P-ISOBUTILFENIL)-PROPIONATO DE 2-HIDROXI-3-(O-METOXI-F ENOXI) PROPILO.SE HACE REACCIONAR EL CLORURO DEL ACIDO 2-(P-ISOBUTIL-FENIL)-PROPIONICO DE FORMULA (II) CON 3-(O-METOXI-FENOXI)-PROPANDIOL DE FORMULA (III) EN UN DISOLVENTE INERTE PARA OBTENER 2-(-P-ISOBUTIL-FENIL)-PROPIONATO DE 2-HIDROXI-3-(O-METOXI-FENOXI)PROPILO DE FORMULA (I). LA REACCION SE VERIFICA A TEMPERATURA COMPRENDIDAS ENTRE 0 Y 60JC, PREFERIBLEMENTE A TEMPERATURA AMBIENTE. SE ACTUA, PREFERIBLEMENTE EN DISOLVENTES APROTICOS, COMO DICLOROMETANO, TETRAHIDROFURANO, DIETILETER Y EN PRESENCIA DE ACEPTORESDE ACIDEZ, COMO PIRIDINA O TRIETILAMINA.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANALGESICOS, ANTIINFLAMATORIOS, ANTIPIRETICOS Y MUCORREGULADORES.
ES517685A 1982-03-10 1982-11-25 Procedimiento para la preparacion de 2-(p-isobutil-fenil)propionato de 2-hidroxi-3-(o-metoxi-fenoxi)propilo. Granted ES517685A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20073/82A IT1190727B (it) 1982-03-10 1982-03-10 Composto ad attivita' analgesica,antiinfiammatoria e mucoregolatrice procedimento per la sua preparazione e relative composizioni farmaceutiche

Publications (2)

Publication Number Publication Date
ES8401009A1 true ES8401009A1 (es) 1983-12-16
ES517685A0 ES517685A0 (es) 1983-12-16

Family

ID=11163583

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517685A Granted ES517685A0 (es) 1982-03-10 1982-11-25 Procedimiento para la preparacion de 2-(p-isobutil-fenil)propionato de 2-hidroxi-3-(o-metoxi-fenoxi)propilo.

Country Status (14)

Country Link
US (1) US4501914A (es)
JP (1) JPS58162554A (es)
BE (1) BE895111A (es)
CH (1) CH650491A5 (es)
DE (1) DE3242961C2 (es)
ES (1) ES517685A0 (es)
FR (1) FR2523124B1 (es)
GB (1) GB2116541B (es)
GR (1) GR77030B (es)
IT (1) IT1190727B (es)
LU (1) LU84486A1 (es)
NL (1) NL8204626A (es)
PT (1) PT75894B (es)
ZA (1) ZA827898B (es)

Families Citing this family (50)

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Publication number Priority date Publication date Assignee Title
IT1212840B (it) * 1983-11-28 1989-11-30 Zambeletti Spa L Derivati di acidi bifenililalcanoici, loro preparazione e composizioni farmaceutiche che licontengono.
WO2014037832A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of epilepsy and neurological diseases
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WO2013167990A1 (en) 2012-05-07 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of depression
CN104603096A (zh) 2012-05-07 2015-05-06 塞利克斯比奥私人有限公司 用于治疗神经肌肉障碍和神经退行性疾病的组合物和方法
WO2013168025A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for treatment of blood clotting disorders
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WO2013167988A1 (en) * 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of cough
WO2013168002A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurological conditions
US9242939B2 (en) 2012-05-10 2016-01-26 Cellix Bio Private Limited Compositions and methods for the treatment of respiratory disorders
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US9394288B2 (en) 2012-05-10 2016-07-19 Cellix Bio Private Limited Compositions and methods for the treatment of asthma and allergy
WO2013167999A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurologic diseases
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US9573927B2 (en) 2012-05-10 2017-02-21 Cellix Bio Private Limited Compositions and methods for the treatment of severe pain
WO2013168016A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of metabolic syndrome
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US9499526B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of neurologic diseases
WO2013168004A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of fibromyalgia pain
US9321775B2 (en) 2012-05-10 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of moderate to severe pain
WO2013175376A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of local pain
CN104583182A (zh) 2012-05-23 2015-04-29 塞利克斯比奥私人有限公司 用于治疗粘膜炎的组合物和方法
JP2015518854A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
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US9227974B2 (en) 2012-05-23 2016-01-05 Cellex Bio Private Limited Compositions and methods for the treatment of respiratory disorders
US9498461B2 (en) 2012-05-23 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
US9187427B2 (en) 2012-08-03 2015-11-17 Cellix Bio Private Limited N-substituted nicotinamide compounds and compositions for the treatment migraine and neurologic diseases
US9624168B2 (en) 2012-09-06 2017-04-18 Cellix Bio Private Limited Compositions and methods for the treatment inflammation and lipid disorders
WO2014037834A2 (en) 2012-09-08 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of inflammation and lipid disorders
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
WO2014195961A1 (en) 2013-06-04 2014-12-11 Mahesh Kandula Compositions and methods for the treatment of diabetes and pre-diabetes
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
WO2016046835A1 (en) 2014-09-26 2016-03-31 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
CA2967908C (en) 2014-09-29 2020-11-17 Mahesh Kandula Compositions and methods for the treatment of multiple sclerosis
AU2014414316B2 (en) 2014-10-27 2020-04-09 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
US9173877B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
JP6679616B2 (ja) 2015-01-06 2020-04-22 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ 炎症及び疼痛の治療のための組成物及び方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150137A (en) * 1975-12-24 1979-04-17 Hisamitsu Pharmaceutical Co. Inc. Pyridylalkyl esters of 2-(p-isobutylphenyl)acetic acid and propionic acids and use
IT1064751B (it) * 1976-07-09 1985-02-25 Acraf P. isobutil idratropato di guaiacolo

Also Published As

Publication number Publication date
CH650491A5 (it) 1985-07-31
PT75894B (en) 1986-01-15
NL8204626A (nl) 1983-10-03
GR77030B (es) 1984-09-04
JPH0121139B2 (es) 1989-04-19
GB2116541A (en) 1983-09-28
DE3242961C2 (de) 1984-05-10
FR2523124B1 (fr) 1985-07-19
ZA827898B (en) 1983-08-31
GB2116541B (en) 1985-10-02
JPS58162554A (ja) 1983-09-27
ES517685A0 (es) 1983-12-16
DE3242961A1 (de) 1983-09-15
BE895111A (nl) 1983-03-16
PT75894A (en) 1982-12-01
IT8220073A0 (it) 1982-03-10
US4501914A (en) 1985-02-26
FR2523124A1 (fr) 1983-09-16
IT1190727B (it) 1988-02-24
LU84486A1 (fr) 1983-06-13

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