ES8307774A1 - Un procedimiento para la preparacion de nuevos derivados de diaminosotiazol. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de diaminosotiazol.

Info

Publication number
ES8307774A1
ES8307774A1 ES513090A ES513090A ES8307774A1 ES 8307774 A1 ES8307774 A1 ES 8307774A1 ES 513090 A ES513090 A ES 513090A ES 513090 A ES513090 A ES 513090A ES 8307774 A1 ES8307774 A1 ES 8307774A1
Authority
ES
Spain
Prior art keywords
formula
dioxides
isothiazole
diamino
oxides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513090A
Other languages
English (en)
Other versions
ES513090A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES513090A0 publication Critical patent/ES513090A0/es
Publication of ES8307774A1 publication Critical patent/ES8307774A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Paints Or Removers (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE DIAMINOISOTIAZOL Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES Y N-OXIDOS, DE FORMULA (I), EN LA QUE M, N Y P VALEN 2-4, 0 O 1 Y 1 O 2, RESPECTIVAMENTE; Y A, X, R, R>2, R>3 Y R>4 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO, DE FORMULA (II), CON AMINAS DE FORMULA R~XA-(CH<2)<N-X-(CH<2)<M-NH<2, EN LAS QUE Z ES AMINO O ALQUILAMINO, Y ES ALCOXI INFERIOR, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, A TEMPERATURAS MODERADAS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA SUPRIMIR LA SECRECION DE ACIDO GASTRICO EN LOS MAMIFEROS.
ES513090A 1981-06-15 1982-06-14 Un procedimiento para la preparacion de nuevos derivados de diaminosotiazol. Expired ES8307774A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27369281A 1981-06-15 1981-06-15

Publications (2)

Publication Number Publication Date
ES513090A0 ES513090A0 (es) 1983-08-01
ES8307774A1 true ES8307774A1 (es) 1983-08-01

Family

ID=23045011

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513090A Expired ES8307774A1 (es) 1981-06-15 1982-06-14 Un procedimiento para la preparacion de nuevos derivados de diaminosotiazol.

Country Status (12)

Country Link
EP (1) EP0067436B1 (es)
JP (1) JPS5838275A (es)
AT (1) ATE20886T1 (es)
AU (1) AU553045B2 (es)
DE (1) DE3272132D1 (es)
DK (1) DK266182A (es)
ES (1) ES8307774A1 (es)
GR (1) GR76149B (es)
IE (1) IE53068B1 (es)
NZ (1) NZ200892A (es)
PT (1) PT75048B (es)
ZA (1) ZA824121B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR77847B (es) * 1981-12-14 1984-09-25 American Home Prod
US4590192A (en) * 1982-10-01 1986-05-20 Beecham Group P.L.C. Benzisothiazoles, their pharmaceutical compositions, and method of use
EP0105732A3 (en) * 1982-10-01 1985-09-04 Beecham Group Plc Histamine h2 receptor antagonists of the benzisothiazole amino and benzthiadiazine amino series
US4567191A (en) * 1983-06-07 1986-01-28 Merck & Co., Inc. Amino-phenyl-thiadiazoledioxides as gastric secretion inhibitors
DE3438073A1 (de) * 1984-10-17 1986-04-24 Ludwig Heumann & Co GmbH, 8500 Nürnberg Butenylderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4578473A (en) * 1985-04-15 1986-03-25 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents
ES2321186T3 (es) 2002-10-09 2009-06-03 Schering Corporation Dioxidos de tiadiazol y monoxidos de tiadiazol como ligandos de los receptores de quimioquinas cxc y cc.
DE602004016211D1 (en) 2003-12-19 2008-10-09 Schering Corp Thiadiazole als cxc- und cc-chemokinrezeptorliganden
CN1918156B (zh) * 2003-12-22 2010-10-27 先灵公司 作为cxc-和cc-趋化因子受体配体的异噻唑二氧化物
SE0500055D0 (sv) * 2005-01-10 2005-01-10 Astrazeneca Ab Therapeutic agents 3
US8952176B2 (en) 2005-06-07 2015-02-10 Shionogi & Co., Ltd. Heterocyclic compound having type I 11 β hydroxysteroid dehydrogenase inhibitory activity
DE602006017849D1 (de) 2005-06-29 2010-12-09 Schering Corp 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc-chemokinrezeptors
CA2613607A1 (en) 2005-06-29 2007-01-04 Schering Corporation Di-substituted oxadiazoles as cxc-chemokine receptor ligands
EP2006286A4 (en) * 2006-03-30 2010-04-07 Shionogi & Co ISOXAZOLE DERIVATIVE AND ISOTHIAZONE DERIVATIVITY WITH ANTICIPATING EFFECT ON 11 TYPE I BETA HYDROXYSTEROIDDEHYDROGENASE
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
GB1496787A (en) * 1974-03-12 1978-01-05 Smith Kline French Lab Heteroalkylthioalkyl amidine derivatives
US4005205A (en) * 1974-04-24 1977-01-25 Smith Kline & French Laboratories Limited Compositions and methods for inhibiting H2 histamine receptors
IN146736B (es) * 1975-10-02 1979-08-25 Smith Kline French Lab
US4145546A (en) * 1975-10-02 1979-03-20 Smith Kline & French Laboratories Limited 4-Pyrimidone compounds
US4216318A (en) * 1975-12-29 1980-08-05 Smith Kline & French Laboratories Limited Heterocyclic alkyl 4-pyrimidones
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
MW5076A1 (en) * 1975-12-29 1978-02-08 Smith Kline French Lab Pharmacologicalle active compounds
NZ186511A (en) * 1977-03-19 1980-11-14 Smith Kline French Lab 3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones
GB1604674A (en) * 1977-05-17 1981-12-16 Allen & Hanburys Ltd Aminoalkyl-benzene derivatives
IE46886B1 (en) * 1977-05-17 1983-10-19 Allen & Hanburys Ltd Aminoalkyl-benzene derivatives
FI781714A (fi) * 1977-06-02 1978-12-03 Smith Kline French Lab Foerfarande foer framstaellning av amidiner
US4210658A (en) * 1977-09-08 1980-07-01 Smith Kline & French Laboratories Limited Amidinosulphonic acid derivatives
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
GB2023133B (en) * 1978-04-26 1982-09-08 Glaxo Group Ltd Heterocyclic derivatives
IL57416A (en) * 1978-05-30 1983-03-31 Smith Kline French Lab Nitro compounds,processes for preparing them and compositions containing them
NL182032C (nl) * 1978-06-05 1987-12-16 Philips Nv Inrichting voor het centreren, richten en vastklemmen van een roterende plaat.
US4374836A (en) * 1978-10-16 1983-02-22 Imperial Chemical Industries Ltd. Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them
US4255428A (en) * 1979-03-24 1981-03-10 Smith Kline & French Laboratories Limited 5-(Hydroxypyridylalkyl)-4-pyrimidones
JPS55145683A (en) * 1979-04-26 1980-11-13 Smith Kline French Lab Pyrimidone derivative
DK160611C (da) * 1979-09-04 1991-09-16 Bristol Myers Squibb Co Analogifremgangsmaade til fremstilling af 3,4-disubstituerede 1,2,5-thiadiazol-1-oxider og -1,1-dioxider
IL61233A (en) * 1979-10-24 1984-08-31 Smith Kline French Lab Guanidino thiazolylalkylamino(alkylthioalkylamino)nitro pyrroles,process for their preparation and pharmaceutical compositions containing them
GR71929B (es) * 1979-11-13 1983-08-19 Ici Ltd

Also Published As

Publication number Publication date
PT75048A (en) 1982-07-01
DK266182A (da) 1982-12-16
IE53068B1 (en) 1988-05-25
AU8476182A (en) 1982-12-23
EP0067436A3 (en) 1983-01-19
ES513090A0 (es) 1983-08-01
EP0067436A2 (en) 1982-12-22
IE821360L (en) 1982-12-15
ATE20886T1 (de) 1986-08-15
NZ200892A (en) 1986-04-11
JPS5838275A (ja) 1983-03-05
EP0067436B1 (en) 1986-07-23
PT75048B (en) 1985-05-17
ZA824121B (en) 1984-01-25
GR76149B (es) 1984-08-03
AU553045B2 (en) 1986-07-03
DE3272132D1 (en) 1986-08-28

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